The National Institute of Diabetes & Digestive & Kidney Diseases

Dr. Rodgers also has been chief of the Molecular and Clinical Hematology Branch since 1998; the branch is now administratively managed by NIH’s National Heart, Lung, and Blood Institute.

Molecular and Clinical Hematology Branch

(1) Plans and conducts basic and clinical research on selected inherited and acquired diseases of human blood, utilizing contemporary biochemical, molecular, and physiological techniques; (2) Develops and validates models, including cellular and transgenic systems, to permit the delineation of regulatory mechanisms in normal and pathological hematopoesis and to facilitate pharmacological or molecular genetic approaches to correct or compensate for abnormalities associated with disease states; (3) Expedites the translation of novel basic scientific discovery to the appropriate level of preclinical or clinical investigation.

Molecular Hematology Section

(1) Plans and conducts research on the molecular and cellular bases of selected congenital and acquired hematological disorders; (2) develops quantitative methods to express disease severity or activity, amenable to sequential applications; (3) studies gene expression and differentiation in erythroid cells in normal and pathological hematopoietic states; (4) studies the molecular basis of lineage-specific differentiation of hematopoietic stem cells; (5) develops therapies for hemoglobinopathies and other genetic blood disorders based on the modification of target gene expression.

Clinical Protocols

• Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients with Sickle Cell Anemia, 01-DK-0088.
  
  
• Peripheral Blood Stem Cell Collection from Adult Volunteers, 02-DK-0160
  
  
• Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease Therapy, 01-DK-0122
  
  
• Peripheral Blood Granulocyte Mobilization and Gene Expression Profiling in Adult Individuals of African Descent, With and Without Benign Ethnic Neutropenia, 03-DK-0168
  
  
• Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Anemia, Thalassemia, and Diamond Blackfan Anemia, 03-DK-0170
  
  

Hsieh MM, Everhart JE, Byrd-Holt DD, Tisdale JF, Rodgers GP Prevalence of neutropenia in the U.S. population: age, sex, smoking status, and ethnic differences. Ann Intern Med(146): 486-92, 2007. [Full Text/Abstract]

Zhuang Z, Huang S, Kowalak JA, Shi Y, Lei J, Furuta M, Lee YS, Lubensky IA, Rodgers GP, Cornelius AS, Weil RJ, Teh BT, Vortmeyer AO From tissue phenotype to proteotype: sensitive protein identification in microdissected tumor tissue. Int J Oncol (28): 103-10, 2006. [Full Text/Abstract]

Shi Y, Chen L, Liotta LA, Wan HH, Rodgers GP Glia maturation factor gamma (GMFG): a cytokine-responsive protein during hematopoietic lineage development and its functional genomics analysis. Genomics Proteomics Bioinformatics(4): 145-55, 2006. [Full Text/Abstract]

Chen L, Zhang H, Shi Y, Chin KL, Tang DC, Rodgers GP Identification of key genes responsible for cytokine-induced erythroid and myeloid differentiation and switching of hematopoietic stem cells by RAGE. Cell Res(16): 923-39, 2006. [Full Text/Abstract]

Liu W, Chen L, Zhu J, Rodgers GP The glycoprotein hGC-1 binds to cadherin and lectins. Exp Cell Res(312): 1785-97, 2006. [Full Text/Abstract]

Lin EE, Rodgers GP, Gladwin MT Hemolytic anemia-associated pulmonary hypertension in sickle cell disease. Curr Hematol Rep(4): 117-25, 2005. [Full Text/Abstract]

Tang DC, Zhu J, Liu W, Chin K, Sun J, Chen L, Hanover JA, Rodgers GP The hydroxyurea-induced small GTP-binding protein SAR modulates gamma-globin gene expression in human erythroid cells. Blood (106): 3256-63, 2005. [Full Text/Abstract]

Rodgers GP Hydroxyurea and new agents for the treatment of sickle cell disease. Clin Adv Hematol Oncol (2): 713-5, 2004. [Full Text/Abstract]

Zoueva OP, Rodgers GP Inhibition of beta protein 1 expression enhances beta-globin promoter activity and beta-globin mRNA levels in the human erythroleukemia (K562) cell line. Exp Hematol (32): 700-8, 2004. [Full Text/Abstract]

Wang M, Tang DC, Liu W, Chin K, Zhu JG, Fibach E, Rodgers GP Hydroxyurea exerts bi-modal dose-dependent effects on erythropoiesis in human cultured erythroid cells via distinct pathways. Br J Haematol (119): 1098-105, 2002. [Full Text/Abstract]

Zhang J, Liu WL, Tang DC, Chen L, Wang M, Pack SD, Zhuang Z, Rodgers GP Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. Gene (283): 83-93, 2002. [Full Text/Abstract]

Chen L, Zhang J, Tang DC, Fibach E, Rodgers GP Influence of lineage-specific cytokines on commitment and asymmetric cell division of haematopoietic progenitor cells. Br J Haematol (118): 847-57, 2002. [Full Text/Abstract]

Gladwin MT, Shelhamer JH, Ognibene FP, Pease-Fye ME, Nichols JS, Link B, Patel DB, Jankowski MA, Pannell LK, Schechter AN, Rodgers GP Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease. Br J Haematol(116): 436-44, 2002. [Full Text/Abstract]

Steinberg MH Rodgers GP Pharmacologic modulation of fetal hemoglobin. Medicine (Baltimore) (80): 328-44, 2001. [Full Text/Abstract]

Tang DC Fucharoen S Ding I Rodgers GP Rapid differentiation of five common alpha-thalassemia genotypes by polymerase chain reaction. J Lab Clin Med (137): 290-5, 2001. [Full Text/Abstract]

Drew LR Tang DC Berg PE Rodgers GP The role of trans-acting factors and DNA-bending in the silencing of human beta-globin gene expression. Nucleic Acids Res (28): 2823-30, 2000. [Full Text/Abstract]

Liu W Wang M Tang DC Ding I Rodgers GP Thrombopoietin has a differentiative effect on late-stage human erythropoiesis. Br J Haematol (105): 459-69, 1999. [Full Text/Abstract]

Tang DC Rodgers GP Activation of the human delta-globin gene promoter in primary adult erythroid cells. Br J Haematol (103): 835-8, 1998. [Full Text/Abstract]

Ebb D Tang DC Drew L Chin K Berg PE Rodgers GP Identification of upstream regulatory elements that repress expression of adult beta-like globin genes in a primitive erythroid environment. Blood Cells Mol Dis (24): 356-69, 1998. [Full Text/Abstract]