HOMOHARRINGTONINE

NSC - 141633

SMILES: COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN5CCC[C@]25C=C1OC

Chemical Name: Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)-butanedioate (ester),[3(R)]-

Other Name: HHT

CAS Registry Number: 26833-87-4

Molecular Formula: C29H39NO9    M.W.: 545.6

How Supplied: For Injection, 10 mg, vial: The product is
supplied as a lyophilized powder in 10 mL amber vials with
mannitol, USP, 50 mg and hydrochloric acid to adjust pH.

Solution Preparation: Vial, 10 mg: When constituted with 4.9
mL of 0.9% Sodium Chloride Injection, USP, each milliliter
contains 2 mg of homoharringtonine with 10 mg of mannitol, USP,
and hydrochloric acid to adjust the pH to 3.0 to 5.0.

Storage: Store the intact vials in the refrigerator (4 to 8 °C).

Stability: Intact vials are stable for 5 years at room temperature
(22-25 °C). Intact vials are stable for at least one year when
stored at elevated temperature (50 °C). The vials bear a 3 year
expiration date.

Constitution as recommended results in a solution which is
chemically and physically stable for 96 hours at room temperature
under normal fluorescent lighting.

Further dilution of the constituted solution to concentrations of
0.05 mg/mL and 0.01 mg/mL in 0.9% Sodium Chloride Injection,
USP, or 5% Dextrose Injection, USP, also results in solutions
which are chemically and physically stable for at least 96 hours at
room temperature under normal fluorescent lighting.

CAUTION: The single-use lyophilized dosage
form contains no antibacterial preservatives.
Therefore, it is advised that the constituted product
be discarded within 8 hours of initial entry.

Route of Administration: Intravenous