TRICIRIBINE PHOSPHATE

NSC - 280594

SMILES: CN1N=C(N)c2cn(C3OC(COP(=O)(O)O)C(O)C3O)c4ncnc1c24

Chemical Name: 1,4 ,5,6,8-Pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-(5-0-phosphono-O-D-ribofuranosyl)-

Other Names: TCN; Tricyclic Nucleoside 5'-Phosphate, TCN-P,
Triciribine Phosphate (USAN)

CAS Registry Number: 61966-08-3

Molecular Formula: C13H17N6O7P     M.W.: 400.3

How Supplied: For Injection, 50 mg, vial: supplied as a white
lyophilized powder with 100 mg of mannitol, USP, and sodium
hydroxide to adjust pH, in 10 mL flint vials.

Solution Preparation: 50 mg/vial: When constituted with
2.5 mL of Sterile Water for Injection, USP, each milliliter
contains 20 mg of triciribine phosphate, 40 mg of mannitol, USP,
and sodium hydroxide to adjust to pH 6.0 to 7.5.

Storage: Refrigerate the intact vials (2-8 °C).

Stability: Shelf-life surveillance of the intact vials is ongoing. The
intact vials are stable for at least 2 years at room temperature (22-
25 °C). The intact vials were found to be unstable when stored at
elevated temperature (50 °C) for one year. The intact vials bear
a "do not use after" date.

Constituted solutions of triciribine phosphate exhibit little or no
decomposition for at least 24 hours at room temperature
(22-25 °C).

Further dilution to a concentration of 1 mg/mL in 0.9% Sodium
Chloride Injection, USP, or Lactated Ringer's Injection, USP, also
results in solutions exhibiting little or no decomposition for at least
24 hours at room temperature. Dilution in 5% Dextrose Injection,
LISP, to a 1 mg/mL concentration resulted in about 3 to 4%
decomposition over 24 hours at room temperature.

CAUTION: The single-use lyophilized dosage
form contains no antibacterial preservatives.
Therefore, it is advised that the constituted product
be discarded within 8 hours of initial entry.

Route of Administration: Intravenous