TIAZOFURIN

NSC - 286193

SMILES: NC(=O)c1csc(n1)C2OC(CO)C(O)C2O

Chemical Name: 4-Thiazolecarboxamide,2-0-D-ribofuranosyl-

Other Names: Riboxamide, TCAR, Tiazofurin (USAN)

CAS Registry Number: 60084-10-8

Molecular Formula: C9H12N2O5S    M.W.: 260.3

How Supplied: Sterile, 1 gm, vial: supplied as a white
lyophilized powder with sodium hydroxide to adjust pH in a 20
mL flint vial.

Solution Preparation: 1 gm/vial: When constituted with 4 6 mL
of Sterile Water for Injection, USP, each milliliter of the resulting
solution contains 200 mg of tiazofurin with sodium hydroxide to
adjust to pH 6 to 8.

Storage: Store the intact vials under refrigeration (2-8 °C).
Stability: Intact vials are stable for 5 years when stored at room
temperature (22-25 °C), and stable for at least one year when
stored at elevated temperature (50 °C).

Constitution as recommended results in a solution which is
chemically stable, exhibiting no decomposition for 7 days at room
temperature while exposed to light.

Further dilution in 5% Dextrose Injection, USP, and 0.9% Sodium
Chloride Injection, USP, to a concentration of 1 mg/mL also
resulted in solutions exhibiting no decomposition for 7 days at
room temperature and exposed to light.

CAUTION: The single-use lyophilized dosage
form contains no antibacterial preservatives.
Therefore, it is advised that the constituted product
be discarded within 8 hours of initial entry.

Route of Administration: Intravenous