ETHIOFOS

NSC - 296961

SMILES: NCCCNCCSP(=O)(O)O

Chemical Name: 2-[(3-Aminopropyl)amino]ethanethiol,dihydrogen phosphate (ester)

Other Names: Ethyo1 ; Amifostine(USAN); Gammaphos;
WR-2721

CAS Registry Number: 20537-88-6

Molecular Formula: C5H15N2O3PS     M.W.: 214.2

How Supplied: For injection, 500 mg, vial: supplied as a
lyophilized powder with 500 mg of mannitol, USP, in 10 mL
amber vials.

Solution Preparation: 500 mg/vial: When constituted with
9.3 mL of Sterile Water for Injection, USP, each milliliter of
solution contains 50 mg of ethiofos and 50 mg of mannitol, USP,
pH 6.0 to 8.0.

Storage: Store the intact vials in the freezer (-20 to -10 °C).

Stability: Shelf-life surveillance studies are continuing.
Intact vials are stable for at least 2 years when stored in the
freezer
(-20 to -10 °C) or at refrigeration temperature (4 °C). Intact vials
are less stable when stored at room temperature.

When constituted as directed, the solution exhibits no
decomposition for at least 8 hours at room temperature
(20-25 °C).

Diluted to a concentration of 10 mg/mL in 5% Dextrose Injection,
USP, or 0.9% Sodium Chloride Injection, USP, ethiofos is stable
for at least 24 hours at room temperature exposed to light or in the
dark.

  CAUTION: This single-use lyophilized dosage
  form contains no antibacterial preservatives.
  Therefore, it is advised that the constituted product
  be discarded within 8 hours of initial entry.

Route of Administration: Intravenous