PYRAZOLOACRIDINE

NSC - 366140

SMILES: n1n(c2c3c1c1c(Nc3c(cc2)[N+]([O-])=O)ccc(c1)OC)CCCN(C)C.CS(=O)(=O)O

Chemical Name: 9-Methoxy-N,N-dimethyl-5-nitropyrazolo-[3,4,5-k1] acridine-2(6H)-propanamine, monomethanesulfonate

CAS Registry Number: 99009-20-8

Molecular Formula: C19H21N5O3.CH4O3S     M.W.: 463.5

How Supplied: Sterile, 100 mg, vial: supplied as a orange-red
lyophilized powder with sodium hydroxide added for pH
adjustment in 10 mL flint vials.

Solution Preparation: 100 mg/vial: constitution with 5.0 mL of
Sterile Water for Injection, USP results in a clear, orange-red
solution at a pH of 4.5 to 6.0 containing 20 mg/mL of pyrazolo-
acridine base.

Further dilution to 0.1 mg/mL with Dextrose 5% in Water, USP
and Sodium Chloride 0.9%, USP in both glass bottles and plastic
bags resulted in solutions that were stable for eight days at storage
temperatures of 4, 25, and 37 °C. Solutions are chemically and
physically stable for 14 days at 4 °and 25 °C.

Storage: Store at room temperature.

Stability: Stability studies of the intact vials are ongoing. One lot
has maintained stability for at least 18 months at room temperature
(22-25 °C). The intact vials were stable at elevated temperature
(50 °C) for 12 months.

The constituted solution is stable for at least 24 hours at room
temperature.

   CAUTION: This single-use lyophilized dosage
   form contains no antibacterial preservatives.
   Therefore, it is advised that the constituted product
   be discarded within 8 hours of initial entry.

Route of Administration: Intravenous