HEXAMETHYLMELAMINE

NSC - 13875

SMILE String: n1c(nc(nc1N(C)C)N(C)C)N(C)C

Chemical Name: N,N,N',N',N ",N "-Hexamethyl-1,3,5-triazine-2,4,6-triamine

Other Names: HMM; Altretamine (USAN); Hexalen®

CAS Registry Number: 645-05-6

Molecular Formula: C9H18N6        M.W.: 210.3

Approximate Solubility:            (mg/mL)

Water                               0.92
Benzene                              106
CHCL3                                220
EtOAc                                 52
Et2O                                  47

Stability:

Bulk: The bulk drug is stable at room temperature.

Solution: Aqueous solutions at pH 4, 7, and 10 are stable for 24 hours at room temperature (UV).

Ultraviolet Absorption:

(Methanol)

max = 227 ± 2 nm            E = 51,400 - 52,400

Gas- Liquid Chromatography:

Column: 10% SP -2100 on 80/120 Supelcoport; glass, 1.83 m x 2 mm i.d.

Carrier Gas: Helium

Flow Rate: 30 mL Helium/minute

Temperatures: Oven 155° C
              Isothermal injector 250° C
              Detector 250° C

Detection: Flame ionization

Internal Standard: Octadecane

Retention Times: 9.6 min (NSC - 13875)
                 17.8 min (I.S.)

Toxicity Data:

Human(po): TDL0 8 mg/kg
Cancer Chemotherapy Reports, 56,505,(1972)

Rat(po): LD50 350 mg/kg
Principles of Insect Chemosterilization, 315,(1968)

Rat(ip): LD50 265 mg/kg
Journal of Pharmacology & Experimental Therapeutics, 100,398,50

Mouse(po): LD50 437 mg/kg
Archives Internationales de Pharmacodynamie et de
Therapie, 160,83,(1966)

Mouse(ip): LD50 200 mg/kg
Cancer Research, 40,2762,(1980)

Mouse(iv): LD50 171 mg/kg
National Technical Information Service, PB293 -046