CARBOPLATIN

NSC - 241240

SMILE String: C1CC2(C1)C(O[Pt](OC2=O)(N)N)=O

Chemical Name: Diammine[ 1,1-cyclobutanedicarboxylat-(2-)]platinum(II),(SP-4-2)-

Other Names: CBDCA; Paraplatin; JM-8

Molecular Formula: C6H12N2O4Pt                M.W.: 371.3

Approximate Solubility:                (mg/mL)
Water                                     > 15
pH 4 Acetate Buffer                     5 - 10
pH 9 Carbonate Buffer                   5 - 10
10% Ethanol/H2O                         5 - 10
95% Ethanol/H                              < 1
0.1NHC1 5                                  -10
0.1NNaOH 5                                 -10
Methanol                                   < 1
Chloroform                                 < 5
Dimethylsulfoxide                            5
Acetic Acid                                < 1
Trifluoroacetic Acid                       < 1

Stability:
 Bulk: No decomposition was detected after 30 days at 60 °C in the dark (HPLC).

 Solution: After 48 hours at room temperature an aqueous solution showed < 1% decomposition (HPLC).

High Performance Liquid Chromatography:

 Column: Unimetrics LiChrosorb RP -8, 250 x 4.6 mm i.d.

 Mobile Phase: Water

 Flow Rate: 1.0 mL/min

 Detection: UV at 205 nm

 Sample Preparation: 0.6 mg/mL in water

 Internal Standard: (0.11 mg uracil/mL water)

 Retention Volume: 6.2 mL (NSC-241240)
                   5.5 mL (I.S.)

Toxicity Data:

 Rat(iv): LD50: 61 mg/kg
 Journal of the National Cancer Institute, 67,201,(1981)

 Mouse(ip): LD L0: 150 mg/kg
 Bioinorganic Chemistry,2,187,(1973)

 Mouse(iv): LD50: 143 mg/kg
 National Technical Information Service, PB82- 165028