CARACEMIDE

NSC - 253272

SMILE String: N(C(=O)NC)(OC(=O)NC)C(=O)C

Chemical Name: N-Acetyl-N-( methylcarbamoyloxy)-N'-methylurea

CAS Registry Number: 81424-67-1

Molecular Formula: C6H11N3O4         M.W.: 189.2

Approximate Solubility:              (mg/mL)

H2O                                    > 76
Methanol                              > 100
Chloroform                            > 100

Stability:

Bulk: The half life at 45 °C is estimated at 8 weeks and the time for 10% decomposition is 2 weeks. The compound is stable at room temperature for 4 weeks (HPLC).

Solution: A 50 mg/mL solution in water at room temperature showed 5% decomposition after 4 hours and 17% decomposition after 24 hours (HPLC).

Ultraviolet Absorption:

(0.1 N HC1)

The spectrum shows end absorption only.

High Performance Liquid Chromatography:

 Column: uBondapak C18, 300 x 3.9 mm i.d.
 Mobile Phase: 20% CH3OH in H2O

 Flow Rate: 1.0 mL/min

 Detection: UV at 210 nm

 Sample Preparation: 0.5 mg/mL in internal standard solution

 Internal Standard: 0.05 mg aniline in 100 mL methanol

 Retention Volume: 6.0 mL (NSC-253272)
                   10.0 mL (I.S.)

Toxicity Data:

 Mouse(po): LD50: 388 mg/kg
 NCI Screening Program Data Summary

 Mouse(ip): L50:D 167 mg/kg
 NCI Screening Program Data Summary

 Mouse(iv): LD50: 238 mg/kg
 National Technical Information Service, PB84- 152032