ETANIDAZOLE

NSC - 301467

SMILE String: c1(nccn1CC(=O)NCCO)[N+]([O-])=O

Chemical Name: 1H-Imidazole-l-acetamide, N-(2-hydroxyethyl)-2-nitro-

Other Names: SR -2508

CAS Registry Number: 22668 -01 -5

Molecular Formula: C7H10N4O4 M.W.: 214.2

Approximate Solubility:         (mg/mL)
Water                            > 100
Methanol                            60
Ethanol                             30
Chloroform                         < 1

Stability:

 Bulk: The sample is stable at room temperature for at least one month (HPLC).

 Solution: As a 10% solution in water, the chemical is stable for at least 24 hours (HPLC).

Ultraviolet Absorption:

(0.1 N HCI)

max = 323 ± 2 nm                 E = 7,540 - 8,020

High Performance Liquid Chromatography:

 Column: 3.9 mm x 30 cm uBondapak C18

 Mobile Phase: 100% H2O

 Flow Rate: 1 mL/min

 Detection: UV at 254 nm

 Sample Preparation: 1 mg/mL in internal standard solution

 Internal Standard: 8.6 mg uracil/100mL H

 Retention Volume: 8.6 mL (NSC-301467) 5.6 mL (I.S.)

Toxicity Data:

 Mouse(ip): LD50: 3300 mg/kg
 Radiation Research, 91,186(1982)

 Mouse(iv): LD50: 4400 mg/kg
 International Journal of Radiation Oncology, Biology and
 Physics, 12,1097(1986)