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Pre-Clinical Research Tools and Resources

NIH has developed several tools and resources to help scientists conduct pre-clinical research. Some of these resources and software tools are listed below.

Small Molecules, Compounds and Probes

PubChem is a freely accessible database of small organic molecules and their activities against biological assays.

NPC logo

NCATS Pharmaceutical Collection is a publicly available, Web-based application that provides complete information on active pharmaceutical ingredients, including small molecule drugs that have been approved by regulatory agencies from the United States, Canada, Europe and Japan, as well as all compounds that have been registered for human clinical trials.

Probes Logo

Probes developed by NIH Chemical Genomics Center (NCGC) scientists, in collaboration with hundreds of extramural scientists, are freely accessible to the scientific community.

Cover of the Assay Guidance Manual

Assay Guidance Manual contains detailed information on developing appropriate assays for high-throughput screening projects.

Informatics Tools

CurveFit logo

NIH Chemical Genomics Center CurveFit serves as a public, stand-alone, open-source version of the Center’s own curve-fitting software. This application automatically fits and classifies thousands of dose-response curves.


Additional NCGC Software and Informatics Tools, including specialized browsers, are available under “Software” in the right-hand column of NCGC’s Tripod server.


NCATS has filed patent applications on several technologies developed by Center investigators. To ensure that these new technologies are further developed and commercialized, we seek collaboration and licensing partners.

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