Joint China-U.S. Workshop on Environmental Pollution and Cancer

photo of China-US workshop attendees

Overview
Purpose
Agenda
Workshop Summary
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Overview

NCI's Epidemiology and Genetics Research Program (EGRP) led a U.S. team in developing the scientific agenda for a workshop with China on environmental pollution and cancer that was hosted by the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences (CAS) in Guangzhou, China, on January 5-8, 2010. The workshop was cosponsored with NIH's Fogarty International Center (FIC), National Institute of Environmental Health Sciences (NIEHS), and National Institute of Child Health and Human Development (NICHD), and CAS.

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Purpose

NIH and CAS each support several existing activities in the area of cancer and environmental health, and desire to expand research in areas of mutual interest in order to reduce the cancer burden in their two countries.

The Workshop's objective was to identify top emerging areas for research cooperation between China and the United States on cancer and environmental health with a focus on the impact of environmental pollution on cancer in children and adults. Each plenary session included discussion of the state-of-the-science, knowledge gaps, methodological issues, critical research questions for future investigation, and opportunities for China-U.S cooperation.

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Tuesday, January 5
Time	Topic
8:00 a.m. - 9:00 a.m.	Registration
9:00 a.m. - 10:00 a.m.	Welcoming Remarks Donghai Wu Director General Assistant Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences Jinghua Cao Professor Deputy Director General Bureau of International Cooperation Chinese Academy of Sciences Ronghui Su Deputy Director General Bureau of Life Sciences and Biotechnology Chinese Academy of Sciences Robert T. Croyle Director Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health
10:00 a.m. - 11:00 a.m.	U.S. Keynote Address: Challenges and Opportunities in Investigating Cancer and the Environment Jonathan Samet University of Southern California
11:00 a.m. - 12:00 p.m.	Chinese Keynote Address: The Current Status and Strategy in the Management of Lung Cancer Yan Sun Cancer Institute & Hospital Chinese Academy of Medical Sciences
12:00 p.m. - 1:30 p.m.	Lunch Break
1:30 p.m. - 1:45 p.m.	Charge to Workshop Participants U.S. Moderator: Gary Ellison National Cancer Institute National Institutes of Health Chinese Moderator: Guangbiao Zhou Institute of Zoology Chinese Academy of Sciences
Plenary Session I: Pollutants, Hazards, and Solutions Chairs: Xinming Wang, Chinese Academy of Sciences and Gary L. Ellison, National Cancer Institute, National Institutes of Health
1:45 p.m. - 3: 45 p.m.	Indoor and Outdoor Exposure to Hazardous Air Pollutants in Urban Guangzhou Xinming Wang Chinese Academy of Sciences Exposure of E-waste Dismantlers to PCBs, OCPs, and PBDEs in South China Xinhui Bi Chinese Academy of Sciences Study on Lung Cancer Prevalence and Prevention Strategy in Xuanwei County of Yunnan Province Yize Xiao Yunnan Centers for Disease Control and Prevention Source Apportionment as Input into Health Effects Studies Philip K. Hopke Center for Air Resources Engineering and Science Clarkson University Challenges in Environmental Epidemiology of Cancer: The Trucking Industry Particle Study as an Example Francine Laden Harvard University Challenges of Measuring Air Pollution: Chemical and Physical Characterization of On-Road and Non-Road Diesel Emissions David R. Cocker, III University of California, Riverside
3:15 p.m. - 3:45 p.m.	Discussion
3:45 p.m. - 4:00 p.m.	Break
Plenary Session II: Tobacco - Carcinogenesis, Prevention, and Control Chairs: Gonghuan Yang, Chinese Centre for Disease Control and Prevention and Deirdre Lawrence, National Cancer Institute, National Institutes of Health
4:00 p.m. - 5:00 p.m.	Trend of Mortality of Lung Cancer and Consumption of Cigarettes in Chinese Gonghuan Yang Chinese Centre for Disease Control and Prevention Analysis of microRNA Expression Profile in Human Lung Adenocarcinoma with Current and Never Smoke Biliang Zhang Chinese Academy of Sciences Changing Patterns and Risks for Smoking Initiation Among Young Women in China Thomas Novotny San Diego State University When Prevention Fails: Cross-Cultural Considerations From the U.S. and China for Shaping Healthy Decisions in the Heat of the Adolescent Brain C. Anderson (Andy) Johnson The Claremont Graduate University
5:00 p.m. - 5:30 p.m.	Discussion
Special Topic: The Huai River Project Introductions: William J. Martin, National Institute of Environmental Health Sciences, National Institutes of Health and Gonghuan Yang, Chinese Centre for Disease Control and Prevention
5:30 p.m. - 6:30 p.m.	Winter Heating or Clean Air? The Unintended Health Consequences of China's Huai River Policy Michael Greenstone Massachusetts Institute of Technology Huai River Integrated Program on Cancer Control and Prevention Xin Sun National Center for Chronic and Non-Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention
6:30 p.m. - 6:45 p.m.	Discussion

Wednesday, January 6
Time	Topic
Penary Session III: Environmental Exposures Related to the Etiology of Cancer in Populations Chairs: Hongbing Shen, Nanjing Medical University and Britt Reid, National Cancer Institute, National Institutes of Health
8:30 a.m. - 10:00 a.m.	Environmental factors and Lung Cancer in Gejiu Tin Mine, Xuanwei County, and Fuyuan County, Yunnan Province, China Yi Cao Kunming Institute of Zoology Views on Risk Factors for Lung Cancer Among Chinese Population Yutang Gao Shanghai Cancer Institute SNPs in 15q25 and Lung Cancer Susceptibility: Ethnic Differences Hongbing Shen Nanjing Medical University Indoor Air Pollution, Environmental Tobacco Smoking, and Risk of Lung Cancer Zuo-Feng Zhang Center for Environmental Genomics University of California, Los Angeles Risk of Lung Cancer in a Cohort of Female Textile Workers in Shanghai David B. Thomas The Fred Hutchinson Cancer Research Center and University of Washington A Prospective Cohort Study in Daqing City, People's Republic of China Tongzhang Zheng Yale University
10:00 a.m. - 10:30 a.m.	Discussion
10:30 a.m. - 10:45 a.m.	Break
Plenary Session IV: Environmental Exposures and Childhood Cancer Chairs: Zhu Li, Peking University and Carol Kasten, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
10:45 a.m. - 11:30 a.m.	Evaluation of Risk Factors for Childhood Cancer using the China Children and Family Cohort Study Zhu Li Peking University Environmental Exposure and Risk of Childhood Cancers Patricia A. Buffler University of California, Berkeley The U.S. National Children's Study - Environmental Influences on the Health and Development of 100,000 Children in the United States Carol Kasten The Eunice Kennedy Shriver National Institute of Child Health and Human Development
11:30 a.m. - 12:00 p.m.	Discussion
12:00 p.m. - 1:30 p.m.	Lunch
Plenary Session V: Lung Cancer Pathogenesis Chairs: Hongbin Ji, Chinese Academy of Sciences and Peter Ujhazy, National Cancer Institute, National Institutes of Health
1:30 p.m. - 2:30 p.m.	Modeling of Human Lung Cancers with EGFR Kinase Domain Mutations Hongbin Ji Chinese Academy of Sciences Artemin Stimulates Progression of Human Non-Small Cell Lung Carcinoma Tao Zhu University of Science and Technology of China NCI's Specialized Program of Research Excellence as a Model for Translational Cancer Research Peter Ujhazy National Cancer Institute New Perspectives on the Influence of Genes and Environment to Lung Cancer and Smoking Neil Caporaso National Cancer Institute
2:30 p.m. - 2:50 p.m.	Discussion
2:50 p.m. - 3:05 p.m.	Break
Plenary Session VI: Pathogenesis and Therapeutics Chairs: Zhihai Qin, Chinese Academy of Sciences and William J. Martin, National Institute of Environmental Health Sciences, National Institutes of Health
3:05 p.m. - 4:20 p.m.	Targeting Stroma for Tumor Rejection Zhihai Qin Chinese Academy of Sciences Monitoring Glycoproteins as a Guide to Prognosis in Chemotherapy Zhili Li Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Cancerous Inhibitor of Phosphatase in Lung Cancer Guangbiao Zhou Institute of Zoology Chinese Academy of Sciences DNA Repair as Predictors of Treatment Response and Survival of Lung Cancer Qingyi Wei The University of Texas MD Anderson Cancer Center Personalization of Cancer Therapy - Advancement and Challenges Zhongxing Liao University of Texas M.D. Anderson Cancer Center
4:20 p.m. - 4:45 p.m.	Discussion

Thursday, January 7
Time	Topic
National Institutes of Health (NIH) Funding Opportunities Panel Discussion
8:30 a.m. - 10:00 a.m.	NIH Funding Opportunities for Collaborative Research Joshua Rosenthal Fogarty International Center How the NIH Grants Process Works Britt C. Reid National Cancer Institute Advice on Grantsmanship from Experienced Investigators Tongzhang Zheng Yale University Qingyi Wei The University of Texas M.D. Anderson Cancer Center
10:00 a.m.- 10:20 a.m.	Break
Chinese Academy of Sciences (CAS) and National Natural Science Foundation of China (NSFC) Funding Opportunities
10:20 a.m. - 12:30 p.m.	NSFC Funding Huai Chen Director, Bureau of International Cooperation National Natural Science Foundation of China CAS Funding Opportunities Panel Discussion Jinghua Cao Deputy Director General, Bureau of International Cooperation Chinese Academy of Sciences Xuliang Zhuang Director, Division of Ecological and Environmental Sciences Bureau of Science and Technology for Resources and Environment Chinese Academy of Sciences Yi Shen Deputy Director, Division of Biomedical Sciences Bureau of Life Sciences and Biotechnology Chinese Academy of Sciences
12:30 p.m. - 2:00 p.m.	Lunch
2:00 p.m. - 5:30 p.m.	Site visit to several locations in Guangzhou to examine natural environmental exposure settings

Friday, January 8
Time	Time
9:00 a.m. - 10:00 a.m.	Closing Remarks Linda Birnbaum Director, National Institute of Environmental Health Sciences National Institutes of Health Donghai Wu Director General Assistant, Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences
10:00 a.m. - 1:00 p.m.	Small collaborative meetings for scientists at various local facilities, universities and laboratories in Guangzhou Planning committee meeting to synthesize the main points, prepare meeting summary, and plan publication of the meeting report(s) (closed meeting)
1:00 p.m. - 2:00 p.m.	Lunch
2:00 p.m. - 4:00 p.m.	Planning Committee Meeting (closed meeting)

The workshop was featured in the NCI Cancer Bulletin and the NIEHS Environmental Factor.

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Workshop Summary

View Executive Summary of the January 2010 Workshop [PDF - 325 KB]

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Contact

Gary L. Ellison, Ph.D., M.P.H., Program Director, Modifiable Risk Factors Branch, EGRP

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Joint China-U.S. Workshop on Environmental Pollution and Cancer

Overview

Purpose

Agenda

Workshop Summary

Contact