The Bedside-to-Bench (B2B) Program funds research teams seeking to translate basic scientific findings into therapeutic interventions for patients and to increase understanding of important disease processes.
The B2B Program accomplishes this mission by addressing barriers, such as the traditional silos between basic and clinical researchers in biomedical research, which can hinder progress toward finding new therapeutics for patients in need. B2B teams involve basic and clinical researchers, often from different NIH Institutes and Centers. In 2006, the B2B program's charge was expanded to unite the efforts of intramural and extramural NIH researchers. Intramural science refers to research that takes place on an NIH campus under the auspices of federal employees, while extramural research is funded by NIH and conducted by investigators and institutions outside of NIH.
The B2B program exemplifies the benefits associated with intramural – extramural collaborations; the extramural community gains access to the Clinical Center's unique resources, and the intramural community can pursue innovative research with extramural investigators.
A B2B award provides up to $135,000 a year for two years. Projects, which are funded by various NIH offices and institutes*, have represented several research categories: AIDS, rare diseases, behavioral and social sciences, minority health and health disparities, women's health, rare diseases drug development, pharmacogenomics, and general.
Through the end of the 2012 program cycle, about 700 principal and associate investigators have collaborated on 209 funded projects with approximately $48M distributed in total bedside-to-bench funding. The introduction of extramural collaborations in 2006 has resulted in partnerships at 74 institutions, 27 of which are Clinical and Translational Science Award sites.
The 2013 cycle of the B2B program has launched. The timeline is outlined below.
| Call for proposals |
|
February 6, 2013 |
| Letters of Intent due |
|
April 3, 2013 |
| Notification of LOI decision |
|
April 19, 2013 |
| Full proposals due |
|
May 31, 2013 |
| Notification to applicants |
|
Early FY 2014
(pending NIH funding by Congress) |
Text version of the slideshow
- Slide One: Bedside-to-Bench logo
- Slide Two: Dr. Frank Maldarelli discusses his project, "New Bioinformatic Approach to Determine HIV Incidence"
- Slide Three: Dr. Manfred Boehm discusses his project, "Aneurysm Formation in Patients with Mutation of STAT3"
- Slide Four: Dr. Jack Yanovski discusses his project, "FTO and Eating in the Absence of Hunger"
- Slide Five: Dr. Joan Hoan discusses her project, "WAGR Syndrome: Clinical Characterization and Correlation with Genotype"
- Slide Six: Dr. Michael Iadarola's discusses his project, "New Treatments for Intractable Pain"
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