Skip Navigation U.S. Department of Health and Human Services
Agency for Healthcare Research Quality
Main Menu
Resource Links
Registries for Evaluating Patient Outcomes: A User's Guide A handbook on the design, implementation, and evaluation of data from registries, developed by AHRQ's Effective Health Care Program
International Network of Agencies for Health Technology Assessment Community of organizations that assess health care technology
Health Technology Assessment Database Centre for Reviews & Dissemination (CRD)

Call for Public Review

Currently Available for Review:
No reviews available at this time

Technology Assessments

Red Envelope Sign Up for Technology Assessments E-Mail Updates

Tip: To find a specific document, use your browser's Find feature (Help).

The Technology Assessment (TA) Program at the Agency for Healthcare Research and Quality (AHRQ) provides technology assessments for the Centers for Medicare & Medicaid Services (CMS). These technology assessments are used by CMS to inform its national coverage decisions for the Medicare program as well as provide information to Medicare carriers.

AHRQ's TA Program uses state-of-the-art methodologies for assessing the clinical utility of medical interventions. Technology assessments are based on a systematic review of the literature, along with appropriate qualitative and quantitative methods of synthesizing data from multiple studies.

Technology assessments may be done in-house by AHRQ staff, or they may be done in collaboration with one of our Evidence-based Practice Centers. When available, technology assessment topics are linked to corresponding information on the CMS Web site. For additional information, please contact the Technology Assessment Program at

Top of Page Top of Page

Public Review

To get complete public review, the AHRQ TA Program will post draft reports on the AHRQ TA Web site. To meet the timelines for Medicare coverage decisions mandated by the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, draft technology assessment reports will be available for public review for a limited time. A notice will be sent out on the CMS Medicare Coverage and AHRQ Effective Health Care E-mail distribution lists 1 week before the posting of draft reports. Each report will be available for public review on this Web site for a total of 2 weeks.

The AHRQ TA Program supports and is committed to the transparency of its review process. Therefore, starting March 18, 2009, invited peer review comments and public review comments will be publicly posted on the TA Program Web site within 3 months after the associated final report is posted on this Web site. The report authors' responses to the comments (the "disposition of comments") will be posted on the same Web page as the associated comments.

Top of Page Top of Page

Technology Assessments Completed


 The Impact of Pre-transplant Red Blood Cell Transfusions in Renal Allograph Rejection
     Disposition of Comments
 Management of Asymptomatic Carotid Stenosis (PDF File, 1.7 MB; Plugin Software Help)
     Disposition of Comments
 Measuring Health-Related Quality of Life for Patients with Diabetic Retinopathy
     Disposition of Comments
 Systematic Review of Decision Tools and their Suitability for Patient-Centered Decisionmaking regarding Electronic Cardiac Device
 Systematic Review of ECG-based Signal Analysis Technologies for Evaluating Patients With Acute Coronary Syndrome
     Disposition of Comments
 Update on Mapping the Landscape of Genetic Tests for Non-Cancer Diseases/Conditions
     Disposition of Comments


 Effectiveness of Cochlear Implants in Adults with Sensorineural Hearing Loss
     Disposition of Comments
 Health Risk Appraisal
     Disposition of Comments
 Lifestyle Interventions for Four Conditions: Breast Cancer, Prostate Cancer, Type 2 Diabetes Mellitus, and Metabolic Syndrome
     Disposition of Comments
 Outcomes of Sipuleucel-T Therapy
     Disposition of Comments
 Update of Horizon Scans of Genetic Tests Currently Available for Clinical Use in Cancers
     Disposition of Comments


 Bone Morphogenetic Protein: The State of the Evidence for On-Label and Off-Label Use
    Disposition of Comments
 Consideration of Evidence on Antiemetic Drugs for Nausea and Vomiting Associated with Chemotherapy or Radiation Therapy
    Disposition of Comments
Diagnosis and Treatment of Secondary Lymphedema
    Disposition of Comments
 ECG-based Signal Analysis Technologies
    Disposition of Comments
 Genetic Tests for Non-Cancer Diseases/Conditions: A Horizon Scan (Updated)
    Disposition of Comments
 Quality, Regulation and Clinical Utility of Laboratory-developed Molecular Tests (Corrected Final Report)
    Errata (PDF file, 94 KB; Plugin Software Help)
    Disposition of Comments
 Radiation Therapy for Localized Prostate Cancer: An Update
    Disposition of Comments
 Report on the Evidence Regarding Off-Label Indications for Targeted Therapies used in Cancer Treatment
    Disposition of Comments
 A Systematic Review of Loss-of-Heterozygosity Based Topographic Genotyping with PathfinderTG® (PDF file, 400 KB; Plugin Software Help)
    Disposition of Comments
 Systematic Reviews on Selected Pharmacogenetic Tests for Cancer Treatment: CYP2D6 for Tamoxifen in Breast Cancer, KRAS for anti-EGFR antibodies in Colorectal Cancer, and BCR-ABL1 for Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
    Disposition of Comments


Cost-Effectiveness of CT Colonography to Screen for ColorectalCancer
 Horizon Scan: To What Extent Do Changes In Third-Party Payment Affect Clinical Trials And The Evidence Base? (PDF file, 520 KB; Plugin Software Help)
 Negative Pressure Wound Therapy Devices
    Disposition of Comments
 Reviews of Selected Pharmacogenetic Tests for Non-Cancer and Cancer Conditions
 Use of Bayesian Techniques in Randomized Clinical Trials: A CMS Case Study
    Disposition of Comments
 White Paper: Potential Conflict of Interest in the Production of Drug Compendia


 Evaluation of the Evidence on Benefits and Harms of Pulmonary Artery Catheter Use in Critical Care Settings
 Home Testing in Management of Chronic Diseases
 Horizon Scan of Invasive Interventions for Lower Extremity Peripheral Artery Disease and Systematic Review of Studies Comparing Stent Placement to Other Interventions
 Horizon Scan: Lipoprotein Subfractions for Identifying Patients at Increased Risks for Cardiovascular Diseases
 Methodological Issues in Evaluation of Innovative Training Approaches to Stroke Rehabilitation
  Non-Pharmacological Interventions for Post-Discharge Care in Heart Failure
 Positron Emission Tomography for Nine Cancers (Bladder, Brain, Cervical, Kidney, Ovarian, Pancreatic, Prostate, Small Cell Lung, Testicular)

* Not available electronically. Contact for report availability.
** Report is completed, but in the process of being prepared for posting. Please check back for updates.

Top of Page Top of Page

Technology Assessments in Progress

Projects in final production phase (post-review)
 Fluorescence In Situ Hybridization (FISH) or Other In Situ Hybridization (ISH) Testing for Chromosomal Damage in Uterine Cervical Cells to Predict Potential for Dysplasia/Malignancy
 Skin Substitutes for Treating Chronic Wounds
 Spinal Fusion for the Treatment of Low Back Pain Secondary to Lumbar Degenerative Disc Disease (Draft)
 Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin

Projects currently under review

Projects in early-mid production phase (pre-review)
 Impact of Neurological Events upon Cognitive Function following Cardiovascular Procedures
 Implantable Defibrillators and the Evidence for Primary Prevention of Sudden Cardiac Death
 Systematic Review on Genomic Testing for Risk of Recurrent Cancer

Technology Assessment Archive

Technology Assessments for 1990-2007

These technology assessments were completed at least 4 years ago, and some as many as 20 years ago. These assessments may be outdated due to more recent research findings not included in the assessments and should be viewed cautiously in current medical practice. They are maintained for archival purposes only.

Top of Page Top of Page


AHRQAdvancing Excellence in Health Care