| Laboratory of Cardiovascular Science |
Intramural Program Investigators ^ Home ^ |
| Kenneth R. Boheler, Ph.D., Investigator Head, Molecular Cardiology Unit Cardiac Function Section |
 Dr. Boheler received his B.Sc. from Duke University and his Ph.D. in Physiology and Pharmacology from the University of California, San Diego. After completing a post-doctoral fellowship and working as a Researcher in Molecular Biology at Unit 127 of the National Institutes of Health and Medical Research (INSERM) in Paris, France, he was appointed Assistant Professor (Lecturer) at Imperial College School of Medicine in the Department of Cardiothoracic Surgery, London, United Kingdom. In October 1996, he joined the NIH in Baltimore to head the Molecular Cardiology Unit of the Cardiac Function Section of the Laboratory of Cardiovascular Science.Research Interests: The primary focus of our research program is two-fold: 1) the analysis of undifferentiated stem cells and early signals of differentiation, and 2) the use of an in vitro differentiation model of mouse and human embryonic stem (ES) cells to understand processes associated with cardiomyocyte differentiation. The Unit actively participates with other groups in the Laboratory of Cardiovascular Science to study aging in rodents and humans, human heart failure and questions associated with apoptosis.We employ a number of molecular, cellular and functional techniques to address these questions; and specifically, we examine the consequences of development and of altered gene expression on the function of specific proteins or lineage commitment. The long-term aim of the research in the laboratory is on the eventual use of these cells and other stem cells both as models for cardiomyocyte differentiation and for therapeutic applications in aging and disease. We actively exploit functional genomics and proteomics to examine the molecular basis of differentiation, development, aging and disease. |
| Contact Information: Laboratory of Cardiovascular Science Gerontology Research Center 5600 Nathan Shock Drive Baltimore, MD 21224-6825 Phone 410-558-8095 Fax 410-558-8150 E mail bohelerk@mail.nih.gov For more information about the Laboratory: http://www.irp.nia.nih.gov/branches/lcs/mcu.htm |
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