Factors influencing the participation of older people in clinical trials - data analysis from the MAVIS trial.

Posted: May 29, 2012
Fearn P, Avenell A, McCann S, Milne AC, Maclennan G, MAVIS Trial Group. J Nutr Health Aging. 2010 Jan. 14. 1. 51-6.
KEYWORDS: Knowledge/Attitudes/Beliefs, Rural, Attitudes, International, Placebo, Study Burden, Consent, Provider Influence, Older Adults, Letter, Non-Cancer

Highlights

Designing trials with older people in mind requires specific considerations.

Why this item may be useful

Older people are less likely to be included in clinical trials. This study explores factors that influence older people’s decisions to participate in randomized clinical trials. The strongest motivator for participation was altruism. Participants valued simple trial designs, which minimize burden on participants, are well organized, and include regular and friendly communication with trial staff. The findings of this survey could be used to plan and design trials in a manner that would maximize recruitment and retention of the elderly.

Details

  • The authors surveyed 540 participants of a nutrition clinical trial in Scotland.
  • The following factors were important in respondents’ decisions to participate in the trial: helping the research team, helping other older people, contributing to medical knowledge, being asked to take part by a doctor, and reducing their own risk of illness.
  • Most participants were concerned about receiving a placebo; explaining reasons for a placebo may help alleviate this concern.
  • About one fifth of respondents indicated unwillingness to participate in future clinical trials.
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