Information for Scientific Collaborators

• Research Collaboration: Procedures and Guidelines
• Orientation Document (study design, data collection, future data analysis, publications)
• Full Text of Questionnaires
• Phase 1 User Manual
• Phase 2 User Manual
• Phase 3 User Manual
• General File User Manual
• Resolved Reproductive Variables User Manual
• Advisory Panel Members
• Overview of Agricultural Health Study Data
• Usage Notes Pertaining to P1-P2 Analysis File
• General File Release Notes
• Phase 2 Release Notes
• Phase 3 Release Notes

Cancer incidence and mortality data on the cohort are being obtained from cancer registries within Iowa and North Carolina and state vital statistics offices on a yearly basis. In addition, mortality data on the cohort is being obtained every other year from the National Death Index (NDI). Cancer incidence in the cohort is presented in Table 2 and mortality in the cohort is presented in Tables 3.

¹ Cancer counts are based on nearly complete registry data through 2008.

² Subjects previously diagnosed with cancer at a different site are included.

³ Buccal cell receipts represent progress through 2010.

⁴ The 'Other' category includes in-situ bladder cancers.

⁵ SEER Site Recode ICD-O-3 (1/27/2003) Definition used for classifying cancers.

Table 4: Medical Conditions asked about in Phase II ¹ (fully expanded accessible table)

	Private Applicators	Spouses	Commercial Applicators	Total
Number in Cohort:	N=52,394	N=32,345	N=4,916	N=89,655
Category	Count	Count	Count
Completed Phase II Questionnaire	33,457	23,796	2,885	60,138
Cardiovascular Disease    Heart Attack (Myocardial Infarction) 1,789 370 122 2,281    Irregular Heart Beat (Arrhythmia) 3,267 2,571 243 6,081    High Blood Pressure or Hypertension 8,637 5,954 870 15,461
Endocrine Disorder    Diabetes or High Blood Sugar 2,429 1,314 188 3,931    Thyroid Disease or Thyroid Problems 1,075 2,947 90 4,112    Overactive Thyroid (Hyperthyroidism) 279 659 N/A 4 938    Graves Disease 62 151 N/A 4 213    Underactive Thyroid (Hypothyroidism) 528 1,792 55 2,375    Thyroiditis, Hashimoto's Disease, Autoimmune Disease 31 212 N/A 4 243    Enlarged Thyroid, Thyroid Nodules, Goiter 204 997 N/A 4 1,201    Other Thyroid Problem 113 169 N/A 4 282
Women's Health Disorder      Endometriosis N/A 2 1,694 N/A 2 1,694    Uterine Fibroids N/A 2 3,514 N/A 2 3,514    Benign Breast Disease (Fibroids, Cysts, Other) N/A 2 4,060 N/A 2 4,060    Pregnancy Induced High Blood Pressure,    Pre-Eclampsia, Toxemia or Eclampsia N/A 2 103 N/A 2 103    Gestational Diabetes N/A 2 77 N/A 2 77
Autoimmune/Musculoskeletal Disorders    Rheumotoid Arthritis N/A 2 908 N/A 2 908    Lupus (SLE) N/A 2 110 N/A 2 110    Sjogren's Disease N/A 2 43 N/A 2 43    Scleroderma or Systemic Sclerosis N/A 2 32 N/A 2 32
Kidney Disorder    Kidney Stones 3,862 1,279 200 5,341    Kidney Disease or Kidney Failure 354 214 28 596
Digestive Disorder    Inflammatory Bowel Disease    (Chron's Disease, Ulcerative Colitis) 430 514 41 985
Skin Disorder    Vitiligo 130 84 N/A 4 214    Eczema 719 1,124 89 1,932    Psoriasis 821 582 76 1,479    Allergy to Bees, Wasps, or Other Insects 1,735 1,120 158 3,013
Optical or Hearing Disorder    Blindness 619 271 36 926    Nearsightedness 12,237 13,244 1,345 26,826    Farsightedness 13,683 11,673 1,217 26,573    Cataracts 3,427 2,965 199 6,591    Glaucoma 680 492 49 1,221    Detached Retina 358 179 30 567    Retinal or Macular Degeneration 391 368 34 793    Hearing Problems 11,781 N/A 3 913 12,694
Injury    Head Injury 6,623 1,556 726 8,905    Neck, Back, Spinal Cord Injury 6,250 2,198 588 9,036    Post-Polio Syndrome, Leg Injury 4,344 1,474 188 6,006
Neurologic Disorder    Epilepsy 123 127 N/A 4 250    Multiple Sclerosis 39 83 N/A 4 122    Parkinson's Disease 89 29 N/A 4 118    Tremor (Essential, Familial, Benign) 144 113 N/A 4 257

¹ Numbers represent medical conditions reported during Phase II interviews. Because the asking of some questions was dependent on responses to earlier questions, the counts in this table reflect the numbers of each condition reported but not the total occurrence of the diseases in the cohort.

² These conditions marked with N/A were not asked about in the men's health questions. Since 96 percent of private applicators and commercial applicators in the cohort are men, it would be misleading to report counts for these conditions in the private applicator column.

³ Hearing problems were not asked about in the women's health questions. Since 99.5 percent of spouses in the cohort are women, it would be misleading to report hearing problem counts in the spouse column.

⁴ These conditions occur in commercial applicators in insufficient numbers to be reported at this time.