Molecular Libraries Probe Production Center Projects
NCGC projects in the Molecular Libraries Probe Production Center Network help biomedical researchers gain access to the large-scale small molecule screening capacity, along with medicinal chemistry and informatics necessary to identify chemical probes to study the functions of genes, cells, and biochemical pathways.
Selected NCGC Molecular Libraries Probe Production Center projects:
- Activators for Human Pyruvate Kinase M2 (hPK) as Leads in Cancer Therapeutics
- Inhibitors of Caspase 1 for the Treatment of Numerous Autoimmune and Inflammatory Diseases
- Inhibitors of Cruzain as Therapeutic Leads for Chagas Disease
- Inhibitors of Cdc2-Like Kinase 4 (Clk4) to Elucidate the Mechanism and Controlling Gene Splicing
- Identification of Inhibitors of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease
- Inhibitors of 12-Human Lipoxygenase (12-hLO) for the Treatment of Diabetes and Clotting
- Agonists of the Thyroid Stimulating Hormone Receptor for the Treatment of Graves’ Disease
- Identification of SMN Modulators for Potential SMA Disease Therapeutics
- Inhibitors of Platelet Integrin αIIbβ3
- Identification of Novel Small Molecule Antagonists of the Neuropeptide-S Receptor
- Inhibitors of Schistosoma Mansoni Redox Cascade
Social Media Links