Latest NIH Alzheimer’s Research Progress Report Available

A new online report from the National Institutes of Health (NIH) highlights recent progress in NIH-supported Alzheimer’s disease research. More»

The NIH "Toolbox" Is Open

A new set of tools to help scientists measure the ways we think, move, feel, and sense the world is ready for use in studies assessing neurological and behavioral outcomes. More»

New Database Aims to Capture International Alzheimer’s Disease Research Efforts

The publicly available International Alzheimer’s Disease Research Portfolio will enable funding organizations to better coordinate research planning, leverage resources, and identify new opportunities. More»

• NIH-supported Alzheimer’s studies to focus on innovative treatments (January 14, 2013)
• NIA researchers find protein PGC-1alpha may play important role in brain health (December 12, 2012)
• NIH-supported international teams identify rare Alzheimer’s disease risk gene variant (November 15, 2012)
• Dr. Neil Buckholtz named head of Division of Neuroscience (October 2, 2012)
• Risk gene for Alzheimer’s disease associated with lower brain amyloid (October 1, 2012)
• Investigators create “brain map” of key epigenetic processes (August 14, 2012)

• Request for Information: Increasing Enrollment in Alzheimers Disease and Related Clinical Trials and Studies
• Preventing Alzheimer’s Disease: What Do We Know?
  New booklet looks at current research on risk factors and prevention strategies
• Read about NIA’s minority research and training activities in NIA’s LINKS e-newsletter
• New online tip sheets for Alzheimer’s caregivers:
  • Bathing (PDF, 619K)
  • Disaster Preparedness (PDF, 613K)
  • End-of-Life Care (PDF, 156K)
  • Going Out (PDF, 401K)
  • Grooming and Dressing (PDF, 168K)
  • Incontinence (PDF, 501K)
  • Managing Medicines (PDF, 625K)
  • Managing Personality and Behavior Changes (PDF, 748K)
  • Money Problems (PDF, 156K)

Major Studies:

• Alzheimer’s Disease Neuroimaging Initiative 2 (ADNI2)—urgently seeking additional volunteers age 55 to 90 with mild to moderate Alzheimer’s disease to participate in this groundbreaking effort
• Dominantly Inherited Alzheimer’s Network (DIAN)—seeking adult children (age 18 and older) with a biological parent who has a known genetic mutation for Alzheimer’s
• Systolic Blood Pressure Intervention Trial, Memory and Cognition in Decreased Hypertension (SPRINT-MIND)—recruiting volunteers age 50 or older with high blood pressure—systolic (upper) number of at least 130—who have a history of heart disease or chronic kidney disease or are at risk for heart disease, but with no history of diabetes or stroke

Drug Trials:

• Gantenerumab for Prodromal Alzheimer's Disease
• Intravenous Immunoglobulin (IGIV), 10%, in Alzheimer's Disease
• RG1662 in Individuals with Down Syndrome
• RO4602522 in Patients with Moderate Alzheimer Disease on Donepezil or Rivastigmine Therapy

Other Trials:

• ADvance Deep Brain Stimulation in Patients with Mild Probable Alzheimer's Disease
• Risk Evaluation and Education for Alzheimer’s Disease (REVEAL) IV
• Metabolic Cerebral Imaging in Incipient Dementia

Exercise Trials:

• Cognitive Benefits of Aerobic Exercise Across the Age Span
• Dose Response Study of Aerobic Exercise in Older Adults
• Fit & Active Seniors Trial (FAST)

Find more trials by searching NIA’s enhanced Alzheimer’s clinical trials finder or contact the ADEAR Center at 1-800-438-4380 (toll-free) or adear@nia.nih.gov.