Program Snapshot
The Common Fund's Genotype-Tissue Expression (GTEx) program aims to study human gene expression and regulation in multiple tissues, providing valuable insights into the mechanisms of gene regulation and, in the future, its disease-related perturbations. Genetic variation between individuals will be examined for correlation with differences in gene expression level to identify regions of the genome that influence whether and how much a gene is expressed. The GTEx project includes the following initiatives:
- Novel Statistical Methods for Human Gene Expression Quantitative Trait Loci (eQTL) Analysis
- Laboratory, Data Analysis, and Coordinating Center (LDACC)
- caHUB Acquisition of Normal Tissues in Support of the GTEx Project
Program Highlights
GTEX pilot project described as one of the most ambitious tissue-collection studies - Nature’s Technology Feature “Building Better Biobanks”
The June 2012 issue of Nature, highlights efforts being made to store high-quality, data-rich biological samples that are essential for research. In the article, GTEx Coordinator Dr. Jeff Struewing, M.D., M.S. (NHGRI) and other members of the GTEx Working Group discuss the various steps throughout the collection process where attention to detail results in high-quality specimens.
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Reference: Nature 2012 June; Volume 486
Common Fund Launches Pilot Phase of the Genotype-Tissue Expression (GTEx) Project
The Common Fund is supporting projects to create
resources that researchers can use to study
inherited susceptibility to illness, including
a tissue bank for future biological studies.
Read the press release...
Additional Information
You and GTEx: Updated Informational Brochure
Visit the GTEx website for Donors and Families
For any questions, please contact Deborah Colantuoni at GTEXInfo@mail.nih.gov
NEW! GTEx Funding Opportunity Announcement
Enhancing GTEx with molecular analyses of stored biospecimens (U01)
RFA-RM-12-009
U01 applications are being solicited to support molecular analyses of stored biospecimens from the Genotype-Tissue Expression (GTEx) project.
Applicants are encouraged to address compelling scientific questions with molecular phenotypes that add value to the resource and take full
advantage of the unique features of GTEx. View more information here.
Frequently Ask Questions for the January 17, 2013 teleconference can be found here.
The GTEx (Genotype-Tissue Expression) Project. Correlations between genotype and tissue-specific gene expression levels will help identify regions of the genome that influence whether and how much a gene is expressed. GTEx will help researchers to understand inherited susceptibility to disease and will be a resource database and tissue bank for many studies in the future.
GTEx moves from pilot to scale up – The GTEx program is creating a comprehensive data and sample resource of genetic variation and gene expression profiles in multiple tissues from post-mortem donors. This resource will aid in the interpretation of Genome Wide Association Studies and help prioritize therapeutic targets by identifying those that affect gene expression.
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