About Colon CFR

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Overview

The Colon CFR includes lifestyle, medical history, and family history data collected from more than 41,000 men and women from 14,500 families with and without colorectal cancer. The Colon CFR began recruiting families in 1997, and all participants are followed up every 5 years to update personal and family histories and expand recruitment if new cases have occurred since baseline.

Family Recruitment
  Male Female Unknown Total
Population-based families* 8,951
Case probandsb 4,324 4,361 0 8,685
Affected relativesb 634 595 0 1,229
Unaffected relativesc 13,208 15,478 0 28,686
Control probandsc 2,039 2,165 0 4,204
Relatives (Australia site only) 2,130 2,126 0 4,256
Total population-based individuals 22,697 25,166 0 47,863
Clinic-based families** 1,711
Affected probandsb 657 594 1 1,252
Unaffected probandsc 111 257 0 368
Affected relativesb 1,068 973 0 2,041
Unaffected relativesc 5,115 5,671 0 10,786
Total clinic-based individuals 6,964 7,525 1 14,490

* Includes population-based case proband families from all sites and population-based control proband families from Australia site.
** Includes all clinic-based proband families (counts family ID of affected and unaffected clinic-based probands).

  1. Enrolled female and male individuals with completed epidemiology questionnaire and/or biospecimen (blood or buccal sample)
  2. Affected with colorectal cancer at baseline interview or biospecimen collection
  3. No history of colon cancer at baseline interview or biospecimen collection

Note: Blood and non-blood relatives/individuals excluding the probands.

Biospecimens Collected to Date

Available Resources
  Male Female Unknown Total
Affected Individualsb Family history/epi dataa,d 5,535 5,621 0 11,156
Proxy family history/epi data 1,014 818 0 1,832
FFQ datae 2,556 2,872 0 5,428
Blood/buccal samples 5,053 5,113 1 10,167
Cell lines 1,706 1,600 0 3,306
Tumor material 4,414 4,230 0 8,644
Unaffected Individualsc Family history/epi dataa,d 13,265 17,264 0 30,528
Proxy family history/epi data 9,228 8,256 0 17,484
FFQ datae 6,178 8,268 0 14,446
Blood/buccal samples 9,196 12,462 0 21,658
Cell lines 926 896 0 1,822
  1. Baseline data for all population-based and clinic-based individuals, males and females
  2. Affected with colorectal cancer at baseline interview or biospecimen collection
  3. No history of colon cancer at baseline interview or biospecimen collection; includes controls from population-based BCFR sites and unaffected clinic-based probands
  4. Excluding proxy questionnaire completion
  5. Food Frequency Questionnaire

Learn more about Colon CFR

Last Updated: 06 Jun 2012

Division of Cancer Control and Population Sciences National Cancer Institute Department of Health and Human Services National Institutes of Health USA.gov