Cancer Pharmacogenomics: Setting a Research Agenda to Accelerate Translation
The Trans-NCI Pharmacogenomics and Pharmacoepidemiology Working Group (PPWG) and Division of Cancer Control and Population Sciences (DCCPS) sponsored the workshop “Cancer Pharmacogenomics: Setting a Research Agenda to Accelerate Translation” on July 21, 2009, on the NIH Campus, Bethesda, MD. The meeting brought together experts from various disciplines in the cancer and pharmacology research communities to identify infrastructures, resources, and pressing clinical issues, and discuss recommendations and priorities to advance cancer pharmacoepidemiology and pharmacogenomics research.
The workshop was organized by Andrew N. Freedman, Ph.D., Chair of the PPWG, and Chief, Clinical and Translational Epidemiology Branch (CTEB) in the Epidemiology and Genetics Research Program (EGRP), DCCPS, and Leah B. Sansbury, Ph.D., M.S.P.H., Co-Chair of PPWG’s Population Sciences Sub-Group, and Program Director, CTEB.
Commentary summarizing the 2009 Workshop and its recommendations:
- Freedman AN, Sansbury LB, Figg WD, Potosky AL, Weiss Smith SR, Khoury MJ, Nelson SA, Weinshilboum RM, Ratain MJ, McLeod HL, Epstein RS, Ginsburg GS, Schilsky RL, Liu G, Flockhart DA, Ulrich CM, Davis RL, Lesko LJ, Zineh I, Randhawa G, Ambrosone CB, Relling MV, Rothman N, Xie H, Spitz MR, Ballard-Barbash R, Doroshow JH, Minasian LM. Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation. J Natl Cancer Inst. 2010 Nov 17;102(22):1698-705.
7:30 a.m. – 8:00 a.m. | Registration |
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8:00 a.m. – 8:30 a.m. |
Welcome and Introduction
James H. Doroshow, M.D., Director, Division of Cancer Treatment and Diagnosis (DCTD), NCI. [PDF, HTML] Andrew N. Freedman, Ph.D., Chief, Clinical and Translational Epidemiology Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences (DCCPS), NCI. [PDF, HTML] |
8:30 a.m. – 8:45 a.m. |
Workshop Overview and Objectives
Leah B. Sansbury, Ph.D., M.S.P.H., Program Director, Clinical and Translational Epidemiology Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences (DCCPS), NCI. [PDF, HTML] |
8:45 a.m. – 9:15 a.m. |
Cancer Pharmacogenomics: Development, Science, and Translation
Richard M. Weinshilboum, M.D., Chair, Division of Clinical Pharmacology and Professor of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine [PDF, HTML] |
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9:15 a.m. – 9:45 a.m. |
Challenges in the Design and Conduct of Clinical Pharmacogenomic Studies
Mark J. Ratain, M.D., Leon O. Jacobson Professor of Medicine, Chairman of the Committee on Clinical Pharmacology, and Associate Director for Clinical Sciences, Cancer Research Center, University of Chicago [PDF, HTML] |
9:45 a.m. – 10:00 a.m. | Break |
10:00 a.m. – 10:30 a.m. |
Interventional Pharmacogenetics: Moving the Science Into Practice
Howard McLeod, Pharm.D., Fred N. Eshelman Distinguished Professor Pharmacogenomics and Individualized Therapy, Eshelman School of Pharmacy, and Director, Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill [PDF, HTML] |
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10:30 a.m. – 11:00 a.m. |
Applications of Cancer Pharmacogenomics in a Naturalistic Setting
Robert S. Epstein, M.D., M.S., Chief Medical Officer and Senior Vice President of Medical and Analytical Affairs, Medco Health Solutions, Inc. [PDF, HTML] |
11:00 a.m. – 11:30 a.m. |
Genome-Guided Clinical Trials to Evaluate the Clinical Utility of Cancer Pharmacogenomics
Geoffrey S. Ginsburg, M.D., Ph.D., Director, Institute for Genome Sciences and Policy, Duke University [PDF, HTML] |
11:30 a.m. – 12:00 p.m. |
Panel Discussion
Moderator: Panelists: Geoffrey Liu, M.D., M.Sc., Alan B. Brown Chair in Molecular Genomics and Scientist, Division of Applied Molecular Oncology, Princess Margaret Hospital, University of Toronto Cornelia Ulrich, Ph.D., Member, Cancer Prevention Program, Fred Hutchinson Cancer Research Center. [PDF, HTML] |
12:00 p.m. – 1:00 p.m. | Lunch |
1:00 p.m. – 1:20 p.m. |
Trans-NCI PPWG Recommendations and Charge to the Group
Andrew N. Freedman, Ph.D., Chief, Clinical and Translational Epidemiology Branch, DCCPS, NCI |
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1:20 p.m. – 3:00 p.m. |
Working Group Breakout Sessions
Each breakout group will be charged with evaluating the Trans-NCI PPWG’s recommendations on moving an NCI research agenda forward in the areas of pharmacoepidemiology and pharmacogenomics. Working Group A Moderators: Robert L. Davis, M.D., M.P.H., Director, Center for Health Research Southeast, Kaiser Permanente of Georgia Working Group B Moderators: Sheila R. Weiss Smith, Ph.D., Professor, Pharmaceutical Health, Services Research Department, University of Maryland, Baltimore Working Group C Moderators: Lori M. Minasian, M.D., Chief, Community Oncology and Prevention Trials Research Branch, Division of Cancer Prevention, NCI |
3:00 p.m. – 3:20 p.m. | Break |
3:20 p.m. – 5:30 p.m. | Working Group Presentations and General Discussion |
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5:30 p.m. – 5:45 p.m. |
Closing Remarks
Andrew N. Freedman, Ph.D., Chief, Clinical and Translational Epidemiology Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences (DCCPS), NCI |