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Agenda
Meeting Objectives
Overall: the NCI's goal in these think tanks is to explore research opportunities at the intersection of the physical sciences and cancer biology that will enable a deeper understanding of cancer and inform the development of better approaches to detect, treat and prevent this complex disease.
- From the perspective of both the physical and biological sciences - to determine the "state of the science" of evolution and evolutionary theory in terms of our current understanding of cancer at all scales.
- To explore the relationships between current areas of intense focus in cancer research, e.g., genomics, proteomics, molecularly based drug discovery and development, etc., in terms of the role of evolution and evolutionary theory in oncology at all scales.
- To identify critical questions in cancer evolution that if addressed will enhance our understanding of cancer development and outcomes.
- For this think tank, to offer guidance on how through leadership, utilization of existing and new research support mechanisms, etc. the NCI can best engage broader communities of physical and biomedical scientist to address key questions in cancer evolution and evolutionary theory applied to cancer.
Outcomes
The conversations that comprise this think tank, including brainstorming sessions, presentations, roundtables and reports from work groups will be captured in a report - and available on an NCI website dedicated to this Physical-Sciences and Frontiers in Oncology Series. In addition, input from the meeting will be utilized to inform new research directions and mechanisms that will hopefully energize and advance this critical field.
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News & Events
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Agenda
| Sunday, July 13 |
| 5:00 p.m. - 6:00 p.m. |
Registration |
| 6:00 p.m. - 7:15 p.m. |
Reception and Buffet Dinner |
Salon II |
| 7:30 p.m. - 7:50 p.m. |
Background for the Meeting
Anna D. Barker, Ph.D.
Deputy Director
National Cancer Institute
Welcome and Introduction of Keynote Presentation
John E. Niederhuber, M.D.
Director
National Cancer Institute |
Salon I |
| 7:50 p.m. - 8:50 p.m. |
Keynote Presentation
The Causes and Prevention of Cancer: Can an Evolutionary Perspective Allow Us to See the Forest and the Trees?
Paul W. Ewald, Ph.D.
Professor and Director, Program on Disease Evolution
University of Louisville |
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Questions and Discussion |
| 8:50 p.m. - 9:00 p.m. |
Think Tank Process Introductions
Anna D. Barker, Ph.D.
Deputy Director
National Cancer Institute |
| 9:00 p.m. - 9:15 p.m. |
Expectations
| Facilitator: |
Robert J. Mittman, M.S., M.P.P.
Founder/President
Facilitation, Foresight, Strategy
Meeting Facilitator |
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| Monday, July 14 |
| 7:00 a.m. - 8:00 a.m. |
Continental Breakfast |
| 8:00 a.m. - 8:30 a.m. |
Welcome
John E. Niederhuber, M.D.
Director
National Cancer Institute
Background for Today's Think Tank
Anna D. Barker, Ph.D.
Deputy Director
National Cancer Institute |
Salons I |
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Process and Flow for the Think Tank
| Facilitator: |
Robert J. Mittman, M.S., M.P.P.
Founder/President
Facilitation, Foresight, Strategy |
Introduction-Keynote Presentation |
| 8:30 a.m. - 10:00 a.m. |
Evolution and Evolutionary Theory in Cancer; Status of the Field
An Environmental Scan
Group Discussion
| Facilitator: |
Robert J. Mittman, M.S., M.P.P.
Founder/President
Facilitation, Foresight, Strategy
Meeting Facilitator |
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| 10:00 a.m. - 10:15 a.m. |
Break |
| 10:15 a.m. - 10:45 a.m. |
Keynote Presentation
Evolution and Cancer: Through the Eyes of a Physicist
Robert H. Austin, Ph.D.
Department of Physics
Princeton University |
| 10:45 a.m. - 11:15 a.m. |
Keynote Presentation
Evolution and Cancer: A Biologist View of the State of the Science
Carlo C. Maley, Ph.D.
Assistant Professor
The Wistar Institute |
| 11:15 a.m. - 12:30 p.m. |
Group Discussions
Evolution and Evolutionary Theory: What are the Critical Questions and/or Barriers?
| Facilitator: |
Robert J. Mittman, M.S., M.P.P.
Founder/President
Facilitation, Foresight, Strategy |
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| 12:30 p.m. - 1:35 p.m. |
Lunch |
| 1:30 p.m. - 3:00 p.m. |
Roundtable Discussion: Exploration of these and Other Critical Questions/Barriers Surrounding Evolution, Evolutionary Theory and Cancer
Roundtable Participants
Paul Davies, Ph.D.
Professor and Director
Beyond Institute
Donald S. Coffey, Ph.D.
Distinguished Professor of Urology
Johns Hopkins University
Raju Kucherlapati, Ph.D.
Scientific Director
Harvard Partners Center for Genetics and Genomics
Brian J. Reid, M.D., Ph.D.
Member, Fred Hutchinson Cancer Research Center
Professor of Medicine, University of Washington
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| 3:00 p.m. - 3:15 p.m. |
Break |
| 3:15 p.m. - 5:15 p.m. |
Evolution and Evolutionary Theory in Cancer - Addressing the Critical Questions (An Integrated Group Conversation)
Group Discussions
Individual Group Facilitation and Reporting
| Facilitator: |
Robert J. Mittman, M.S., M.P.P.
Founder/President
Facilitation, Foresight, Strategy |
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| 5:15 p.m. - 5:45 p.m. |
Quick Hit (Headlines) Report From the Groups
| Facilitator: |
Robert J. Mittman, M.S., M.P.P.
Founder/President
Facilitation, Foresight, Strategy |
Plan for Tomorrow |
| 6:30 p.m. |
Reception and Dinner |
Foyer Salon I |
| Tuesday, July 15 |
| 7:00 a.m. - 8:00 a.m. |
Continental Breakfast |
| 8:00 a.m. - 8:15 a.m. |
Review of Day 1
| Facilitator: |
Robert J. Mittman, M.S., M.P.P.
Founder/President
Facilitation, Foresight, Strategy |
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Salon I |
| 8:15 a.m. - 8:45 a.m. |
Keynote Presentation
Breast Cancer: Would Evolutionary Thinking Change Our Understanding and Management of this Complex Disease?
Larry Norton, M.D.
Deputy Physician-in-Chief for Breast Cancer Programs
Memorial Sloan-Kettering Cancer Center |
| 8:45 a.m. - 10:15 a.m. |
Panel: Research and Commentary - Cancer in the Context of Evolution
(Cancer as Viewed by Evolutionists; Development of Interventions - What Could Change? Modeling in the Context of Evolution)
Cell Lineages - Mutations - and "Predisposition" to Cancer
Steven A. Frank, Ph.D.
Professor
University of California at Irvine
Dynamics of Multilevel Selection and Cancer
John W. Pepper, Ph.D.
Assistant Professor
University of Arizona
Applying Evolutionary Principles and Theory to the Development of Interventions for Cancer
Kenneth J. Pienta, M.D.
Professor
The University of Michigan
Evolution and New Models for Cancer Development and Progression: What Will It Take to Inform the Models?
Thomas S. Deisboeck, M.D.
Assistant Professor
Harvard-MIT (Massachussetts General Hospital)
Questions/Discussion
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| 10:15 a.m. - 10:30 a.m. |
Break |
| 10:30 a.m. - 1:30 p.m. |
Converging on the Key Areas of Focus* |
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Group Discussions - Concept Development Groups Input and Recommendations |
Salon I, Attaché and Ambassador |
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Working Lunch
Concept work groups continue and prepare to report out |
| 1:30 p.m. - 2:45 p.m. |
Report Outs: Group Consensus Input - Report Format and Direction and Timing |
Salon I |
| 2:45 p.m. - 3:00 p.m. |
Summary and Next Steps
John E. Niederhuber, M.D.
Director
National Cancer Institute
Anna D. Barker, Ph.D.
Deputy Director
National Cancer Institute |
* Converging on the Key Areas for Focus (Major Questions in the Field; Scientific Focus Areas; Key Steps Needed to Enable Progress in the Field; Resource Needs (teams needed; most appropriate mechanistic approaches; and other suggestions as appropriate). Beyond graphic summary, develop outline for section of the meeting report.
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