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This list was compiled by the Human Genome Management Information System (HGMIS), sponsored by the U.S. Department of Energy (DOE), Office of Science, at Oak Ridge National Laboratory.
Quick Index
See Also: Links to the Genetic World and Virtual Library on Genetics.
DOE Genome Programs http://genomics.energy.gov
Genomic Science Program, http://genomicsgtl.energy.gov
Program using genomic data and technologies to study proteins and explore the
diverse capabilities of microbes to help solve DOE mission challenges.
Human Genome Project Information (HGPI), www.ornl.gov/hgmis/home.html
Covers many topics related to U.S. and worldwide genome projects. Useful for
updating scientists and providing educational material for nonscientists.
Microbial Genome Program,
microbialgenomics.energy.gov
Describes the DOE program that sequences microbial genomes, some for further
study in the Genomic Science Program. Microbial genome sequences potentially
can unlock beneficial applications in bioremediation, climate change, biotechnology,
energy production, and other vital areas.
Genomic Science Program Applications: Energy,
Climate, and the Environment
Missions Overview of Genomic Science Program Research, genomicsgtl.energy.gov/benefits/
Enabling Technologies, genomicsgtl.energy.gov/technology/
Descriptions of technologies that allow the systems approach to biology in the
Genomic Science Program.
Environmental Remediation Sciences Program, www.lbl.gov/ERSP/
Strategies leading to long-term immobilization of radionuclides and metals in
soil at DOE sites.
Glossary of Environment and Microbiology Terms, www.alken-murray.com/glossarybug.html
Microbial Genomics
DOE Microbial Genome Program, microbialgenomics.energy.gov
and www.jgi.doe.gov/genome-projects/
Sites describing the program started in 1994 to aid in fulfilling DOE's missions;
show finished and in-progress microbes being sequenced by JGI.
DOE Joint Genome Institute, www.jgi.doe.gov
Microbial information and data from DOE's sequencing central. In addition to
microbes, JGI sequences other organisms of interest to DOE.
Genomes OnLine Database (GOLD), http://wit.integratedgenomics.com/GOLD/
Completed and ongoing genome projects, including microbial, around the world.
Comprehensive Microbial Resources at TIGR, www.tigr.org/tigr-scripts/CMR2/CMRHomePage.spl/
Access to data from completed bacterial sequences.
Microbes.info, www.microbes.info
Site includes general, environmental, food, industrial, medical, and veterinary
microbiology as well as news, articles, FAQs, companies, and employment information.
Microbe World, www.microbeworld.org
Activities and resources on microbial genomics for teachers and students.
Microbes in Action, www.umsl.edu/~microbes/
Scientific information and hands-on activities in microbiology for K–12
teachers via curriculum units, workshops, newsletter, and Web site.
Systems Biology
Institute for Systems Biology, www.systemsbiology.org/
Nonprofit research institute devoted to the study of systems biology.
Systems Biology: New View of life, www.eurekalert.org/features/doe/2001-01/drnl-sb061802.php/
From U.S. DOE Research News.
Proteomics
Harvard Institute of Proteomics, www.hip.harvard.edu
Institute studying the uses of genomic information for proteomic structure determination.
Protein Structure Initiative, www.nigms.nih.gov/psi/
Devoted to studies that take a genomics or computational approach to determining
protein structures.
Pharmaceutical Proteomics Glossaries and Taxonomy, www.genomicglossaries.com/content/proteomics.asp
Evolving terminology for emerging technologies from Cambridge Healthtech Institute.
ExPASy proteomics server, Swiss Institute of Bioinformatics,
http://us.expasy.org/
Dedicated to the analysis of protein sequences and structures.
Human Proteome Initiative (HPI), http://us.expasy.org/sprot/hpi/
Project to annotate all known human protein sequences to the quality standards of Swiss-Prot,
including information on each known protein.
Human Proteome Organisation, www.hupo.org
International group formed to further the understanding of human proteins and
to realize the benefits of proteomics by encouraging cooperation among scientific,
governmental, and financial communities.
Swiss Proteomics Society, www.swissproteomicsociety.org
Organization to promote research and education in the science of proteomics
in Switzerland and other countries.
Proteomics Standards Initiative, www.ebi.ac.uk/Information/meetings/psi.html
Aims to define community standards for data representation in proteomics to
facilitate data comparison, exchange, and verification.
Genome Resources, Including Bioinformatics
Joint Genome Institute, www.jgi.doe.gov/
DOE’s facility for sequencing microbes and other organisms pertinent to
DOE missions.
Comprehensive Microbial Resource at TIGR, www.tigr.org/tigr-scripts/CMR2/CMRHomePage.spl
DOE-sponsored tool that allows researchers to access all the bacterial genome
sequences completed to date.
Genomes OnLine Database (GOLD), http://wit.integratedgenomics.com/GOLD/
Monitors details of genome sequencing projects worldwide, including those sponsored
by DOE.
Entrez Genome: NCBI, www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Genome
Squenced and unfinished genomes, including viruses, bacteria, archaea, and eukaryotes.
Ensembl Genome Browser, www.ensembl.org/
Anotated sequence data and chomosomes of select eukaryotic genomes.
UCSC Genome Browser Gateway, http://genome.ucsc.edu/cgi-bin/hgGateway
Human, mouse, rat, SARS, and many other genomes.
Enabling Technologies, genomicsgtl.energy.gov/technology/
Descriptions of technologies that allow the systems approach to biology.
National Center for Biotechnology Information (NCBI), www.ncbi.nlm.nih.gov/
Public databases, research in computational biology, software tools for analyzing
genome data, and biomedical information.
Entrez is the integrated, text-based search and retrieval system used at NCBI for the major databases, including PubMed, Nucleotide and Protein Sequences, Protein Structures, Complete Genomes, Taxonomy, and others. http://www.ncbi.nlm.nih.gov/sites/gquery
European Bioinformatics Institute (EBI), www.ebi.ac.uk/Information/index.html
European Molecular Biology Laboratory (EMBL) research center that manages databases
of biological data including nucleic acid, protein sequences, and macromolecular
structures.
Some databases available from EBI include:
- EMBL Nucleotide Sequence Database, www.ebi.ac.uk/embl/index.html
Europe's primary DNA and RNA sequence resource. - Swiss-Prot, www.ebi.ac.uk/swissprot/index.html
Annotated database of protein amino acid sequences. - EBI Macromolecular Structure Database, www.ebi.ac.uk/msd/index.html
European project for the collection, management and distribution of data about macromolecular structures, derived in part from the Protein Data Bank (PDB).
ExPASy (Expert Protein Analysis System) Molecular Biology Server,
http://us.expasy.org/
Databases and tools for the analysis of protein sequences and structures from
the Swiss Institute of Bioinformatics. Another resource for accessing Swiss-Prot
protein sequence databases.
Protein Data Bank (PDB), www.rcsb.org/pdb/
Single worldwide repository for processing and distribution of 3-D biological
macromolecular structure data.
Genome Applications: Medical Genetics
HGPI "Medicine and the New Genetics" page, www.ornl.gov/hgmis/medicine/medicine.shtml
Information on how genetic knowledge is changing the practice of medicine. Many
good links.
Gene Gateway, www.ornl.gov/hgmis/posters/chromosome/
Guides and tutorials to aid the novice or layperson in finding and using the
wealth of genetic information available on the Internet.
Disease InfoSearch (DIS), www.geneticalliance.org
Catalogue of rare to common genetic conditions, searchable by several parameters.
Online Mendelian Inheritance in Man (OMIM), www.ncbi.nlm.nih.gov/sites/entrez?db=omim
A comprehensive, authoritative, and up-to-date human gene and genetic-disorder
catalog that supports medical genetics.
Blazing a Genetic Trail (1991), www.hhmi.org/genetictrail/
Illustrated booklet from the Howard Hughes Medical Institute on hunting for
disease genes.
GeneCards, bioinformatics.weizmann.ac.il/cards/
Database of human genes, their products, and their involvement in disease.
Genetic Alliance, www.geneticalliance.org
Formerly called the Alliance of Genetic Support Groups. Coalition of individuals,
professionals, and support organizations for people with genetic diseases and
their families. Includes a directory of national genetic voluntary organizations
and related resources.
Disease InfoSearch, www.geneticalliance.org/
Catalogue of rare to common genetic conditions searchable by clinical description,
treatment research, genetic (molecular) information, support groups, references,
insurance issues, arts and literature, and other resources.
NIH Office of Biotechnology Activities, www.nih.gov/od/oba/
Background information on advisory committees that provide policy advice to
the Secretary of Health and Human Services on gene therapy, genetic testing,
and xenotransplantation.
Understanding Gene Testing, www.cancer.gov/cancertopics/understandingcancer/genetesting
Illustrated brochure from the National Cancer Institute.
Promoting Safe and Effective Genetic Testing in the United States (1997),
www.genome.gov/10001733
Principles and recommendations by a joint NIH-DOE group that examined the development
and provision of gene tests in the United States.
Ethical, Legal, and Social Issues (ELSI)
Related to Genetics Research
HGPI ELSI Issues page, www.ornl.gov/hgmis/elsi/elsi.shtml
Discusses societal concerns such as privacy and legislation, patenting, forensics,
gene testing, gene therapy, and genetics in the courtroom.
HGPI ELSI Research page, www.ornl.gov/hgmis/research/elsi.shtml
Includes project goals related to ELSI, DOE-funded ELSI research and products.
HGPI Gateways ELSI links, www.ornl.gov/hgmis/links3.shtml#elsi
Extensive list of links to ELSI-related sites.
Genetics and Ethics, www.genethics.ca/index.html
Lots of good links.
Center for Bioethics, University of Pennsylvania, www.med.upenn.edu/bioethic/
Full-text articles about such ethical issues as human cloning; includes a primer
on bioethics.
Eubios Ethics Institute, www.eubios.info
Papers and teaching materials on bioethics and biotechnology.
Genetic Privacy Act, www.ornl.gov/hgmis/resource/privacy/privacy1.html
Model legislation written with support of the DOE Human Genome Program.
Your Genes, Your Choices (1999), http://ehrweb.aaas.org/ehr/books/index.html
Booklet written in simple English, describing the Human Genome Project; the
science behind it; and how ethical, legal, and social issues raised by the project
may affect people's everyday lives.
National Organization for Rare Disorders, www.rarediseases.org-- NORD, a nonprofit organization, serves as an international clearinghouse of information on over 5,000 rare disorders. Refer to their Contact NORD page for telephone, TDD, and other contact information.
Genetic Alliance -- www.geneticalliance.org non-profit organization dedicated to helping individuals and families who have genetic disorders. Tel: 202-966-5557, Fax: 202-966-8553, info@geneticalliance.org
Education
Many of the following sites contain both educational and technical material.
HGPI Education page, www.ornl.gov/hgmis/education/education.shtml
Resources for teachers and students.
Gene Gateway, www.ornl.gov/hgmis/posters/chromosome/
Guides and tutorials to aid the novice or layperson in finding and using the
wealth of genetic information available on the Internet.
Educational Resources from National Human Genome Research Institute,
www.genome.gov/Education/
Curriculum supplements, genetic education modules, talking glossary, and information
on training, careers, internships, and mentorships.
NIH Office of Science Education and Outreach, science.education.nih.gov/
Includes fact sheets on such technologies as chromosome microdissection, DNA
chips and microarrays, karyotyping, fluorescence in situ hybridization, and
polymerase chain reaction.
Roslin Institute, www.roslin.ac.uk/
Leading center for animal biotechnology. Home of Dolly, the cloned sheep. Includes
an image gallery.
Howard Hughes Medical Institute, www.hhmi.org
Home page of major U.S. philanthropic organization that supports research in
a number of topics, including genetics, cell biology, immunology, structural
biology, and neuroscience.
Biotechnology Institute, www.biotechinstitute.org
Site dedicated to education and research about the present and future impact
of biotechnology. Includes downloadable .pdf files of current and past issues
of Your World student magazine and links to FAQs, teacher workshops, and career
profiles.
Genomics Course Outline, www.bio.davidson.edu/Courses/genomics/genomics.html
Outline, syllabus, and student Web pages to accompany the book Discovering Genomics,
Proteomics, and Bioinformatics (Cold Spring Harbor Press, 2002), used in a Davidson
College course taught by one of the book’s authors, A. Malcolm Campbell.
DNA Learning Center, Cold Spring Harbor Laboratory, www.dnalc.org
Animated genetics primer, biology library, and a section on the history of eugenics.
DNA Interactive, www.dnai.org/index.html
Outstanding interactive modules, including timeline, DNA code, manipulation,
genome, applications, and implications. Teacher guides, multimedia lesson builder,
and outstanding pictures and text.
Genetics Education Center, University of Kansas Medical Center,
www.kumc.edu/gec/
Educational information on human genetics, career resources.
Genetic Science Learning Center, http://gslc.genetics.utah.edu/
Basic genetic science activities and hands-on experiments for teachers and students,
scientist profiles.
Introduction to Genetics from GlaxoSmithKline, http://genetics.gsk.com/overview.htm
Basics of genetics, DNA, DNA and human diversity, mutations, and genes.
About Biology, http://biology.about.com/
Genetics basics, including links to principles, primers, glossaries, disorders,
inheritance, and online books.
Access Excellence, www.accessexcellence.org/index.html
Extensive genetic and biotechnology resources for teachers and nonscientists.
The Biology Project: Human Biology, www.biology.arizona.edu
Includes problem sets and tutorials on blood types, color blindness, forensics,
karyotyping, and other topics.
Educating the Biotechnology Workforce, www.bio-link.org/resource.htm
Collection of instructional and curriculum materials targeted to biotechnology
technicians and bench scientists.
High School Human Genome Program, http://hshgp.genome.washington.edu/
Resources for teachers and students.
The Why Files, whyfiles.org
Illustrated explanations of the science behind the news.
Electronic Scholarly Publishing, www.esp.org
Reprints of classic papers in genetics, history of science, computational biology,
and genome research. Also see Access Excellence site above for genetics history.
Frank Potter's Science Gems www.sciencegems.com
Links to science resources
Genetics Glossary, www.ornl.gov/hgmis/glossary/
Terms related to genetics and genomics.
CERN Virtual Library, Genetics Section, Biosciences Division,
https://public.ornl.gov/hgmis/genetics/default.cfm
Includes an organism index linking to other pertinent databases, information
on U.S. and international genome projects, and links to research sites.
BioTech, biotech.icmb.utexas.edu
Interactive educational resources and biotech reference tools, dictionary of
thousands of life science terms. Online courses.
The Molecules of Life, biop.ox.ac.uk/www/mol_of_life/Molecules_of_Life.html
Simple interactive introduction to laboratory techniques used to understand
the structure of protein molecules. For general audiences.
Human Genome News, www.ornl.gov/hgmis/publicat/hgn/hgnarch.shtml
Archive of articles written for newsletter that reported on the Human Genome
Project and its spinoffs.
The Genomic Revolution, www.amnh.org/exhibitions/genomics/0_home/
Interactive 2001–2002 exhibit at the American Museum of Natural History.
Simple explanations of genetics basics as well as information on comparative
genomics research at the museum.
The DNA Files, www.dnafiles.org
Web site developed in conjunction with a 9-hour series of documentaries broadcast
on PBS. Many good resources and links.
Genetics Websites en Español, www.ornl.gov/hgmis/education/spanish.html
For Spanish-speaking users.
Images on the Web
Genome Science, Tools, and Technologies, public.ornl.gov/hgmis/gallery/
Downloadable images.
Access Excellence, www.accessexcellence.org/AB/GG/
Graphics gallery, including labeled diagrams and summaries of information on
the important processes of biotechnology.
Chromosome Chooser, www.ornl.gov/hgmis/posters/chromosome/chooser.shtml
Maps of all human chromosomes with a list of disease genes found on each.
Cells Alive! www.cellsalive.com
Images (some moving) of different types of cells.
Training and Careers
HGPI Careers in Genetics and Biosciences, www.ornl.gov/hgmis/education/careers.shtml
Possible jobs and professions related to genetics and the biosciences.
Careers in Genetics, www.faseb.org/genetics/gsa/careers/bro-menu.htm
Online booklet from the Genetics Society of America, including profiles of geneticists.
See also career sections of such sites as Access Excellence.
SciWeb Biotechnology Career Center, www.biocareer.com/feature.cfm?Source=BIO/
Information about careers in biotechnology and advice on all aspects of job
searching.
Science Careers Web, www.sciencecareersweb.net/
Numerous valuable resources on science careers, including geoscience, biological
and marine science, news, and professional societies.
Guide to Career Opportunities in Ecology and Environmental Science,
www.louisville.edu/a-s/biology/ecojobs.html
Describes possible jobs, courses to take, and preparing for and applying to
graduate school.
Careers in Industrial Microbiology and Biotechnology, www.simhq.org/careers/careers.aspx
From the Society for Industrial Microbiology.
Careers in the Microbiological Sciences, www.asm.org/Education/index.asp?bid=1272
From the American Society for Microbiology.
Unlocking Life’s Secrets: Careers in Biochemistry and Molecular
Biology, http://www.asbmb.org/ASBMB/site.nsf/Sub/CareerBrochure?opendocument
From the American Society for Biochemistry and Molecular Biology.
Careers in Biotechnology, www.accessexcellence.org/AB/CC/index.html
Includes job descriptions, selected resources, and interviews with scientists
in a variety of fields.
Workforce Development for Teachers and Scientists, www.scied.science.doe.gov/scied/sci_ed.htm
Information on undergraduate internships, Science Bowl competitions, and other
programs such as fellowships for teachers. From DOE Office of Science.
Research and Training Opportunities at NIH, www.training.nih.gov/
For high school, college, postdoctoral, and medical and dental students. Also
Continuing Medical Education for physicians and psychologists.
National Human Genome Research Institute, www.genome.gov/10000212
Includes information on training, careers, internships, and mentorships.
Educational and Research Experiences, www.orau.gov/orise/educ.htm
Lists a number of federal laboratory opportunities all over the country.
Bioethics jobs, www.bioethics.net/bioethicsjobs.php
Lists open bioethics positions in the United States, Canada, and Great Britain.
Science in the News
Top Science Stories, http://www.latimes.com/news/science/
Science stories from the Los Angeles Times, links to archives since 1990.
Genome News Sources, www.ornl.gov/hgmis/archive/headlines.shtml#sources/
Web sources of news and headlines related to genetics and the HGP.
Bioinform News Service, http://www.bioinform.com/issues/
Focused exclusively on the global bioinformatics community.
Centers for Disease Control Genomics Weekly Update, www.cdc.gov/genomics/update/current.htm
Impact of human genetic research on disease prevention and public health.
Genome Biology, genomebiology.com/researchnews/
Research news about biology in the post-HGP era.
Genome Web, www.genomeweb.com
News for the New Biology.
Nature and Nature Genetics Genome Gateway, www.nature.com/genomics/news/index.html
Special index of genetics-related articles.
EurekAlert! www.eurekalert.org/
Summaries of major stories and links to news sources.
Science Daily, www.sciencedaily.com
Headline stories, articles, and links to news services, newspapers, magazines,
broadcast sources, journals, and organizations.
Science Magazine Functional Genomics, www.sciencegenomics.org
Archived (as of February 2005) collection of Web resources, page on genomic special issues, links to
news sources.
Biotechnology Business Web Sites
HGPI Biological and Genetics Commercial Sites, www.ornl.gov/hgmis/links2.shtml
Many links to great sites on a wide range of topics.
bioOnline, www.bio.com
Industry news, reports, and analyses. Research news and education, career center.
BIO, www.bio.org
News and views from the Biotechnology Industry Organization, including a section
on bioethics and biomedical research.
DNA Patenting and Biotechnology, dnapatent.com
Online guide to DNA patenting and genetic engineering for nonlawyers and nonscientists.
Signals, www.signalsmag.com
Online magazine of biotechnology industry analysis.
Pew Initiative on Food and Biotechnology, http://pewagbiotech.org
News and information on agricultural biotechnology and genetically modified
food from an independent and objective source.
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