Short chain dehydrogenase/reductase superfamily
Kallberg Y, Oppermann U, Persson B. Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models. FEBS J. 2010 May;277(10):2375-86. PMID:20423462
Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. Chem Biol Interact. 2009 Mar 16;178(1-3):94-8. PMID:19027726
| 1. Classical SDR fold cluster 1 |
| 2. Classical SDR fold cluster 2 |
| 3. Classical SDR fold cluster 3 |
| 4. Extended SDR fold |
| 5. Atypical members |
Click on the Approved Gene Symbol to retrieve the complete gene record
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| HSD17B10 | hydroxysteroid (17-beta) dehydrogenase 10 | HADH2, MRXS10 | ERAB, MHBD, 17b-HSD10, ABAD, SDR5C1, MRPP2, CAMR | Xp11.2 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | C9orf99 | SDR13C1 | 9q32 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | DHRS6 | UCPA-OR, FLJ13261, UNQ6308, PRO20933, SDR15C1 | 4q24 |
| DECR2 | 2,4-dienoyl CoA reductase 2, peroxisomal | PDCR, SDR17C1 | 16p13.3 | |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | DECR | SDR18C1 | 8q21.3 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | FLJ25430, MGC20204, SDR19C1 | 14q11.2 | |
| DCXR | dicarbonyl/L-xylulose reductase | KIDCR, DCR, SDR20C1 | 17q25.3 | |
| CBR1 | carbonyl reductase 1 | CBR | SDR21C1 | 21q22.1 |
| CBR3 | carbonyl reductase 3 | SDR21C2 | 21q22.2 | |
| DHRS11 | dehydrogenase/reductase (SDR family) member 11 | MGC4172, SDR24C1 | 17q12 | |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | HEP27, SDR25C1 | 14q11.2 | |
| DHRS4 | dehydrogenase/reductase (SDR family) member 4 | SCAD-SRL, SDR-SRL, humNRDR, FLJ11008, SDR25C2 | 14q11.2 | |
| DHRS4L2 | dehydrogenase/reductase (SDR family) member 4 like 2 | SDR25C3 | 14q11.2 | |
| DHRS4L1 | dehydrogenase/reductase (SDR family) member 4 like 1 | SDR25C4 | 14q11.2 | |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | HSA250303, TERP, SDR29C1 | 2q35 | |
| HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 | FABGL | HKE6, D6S2245E, RING2, KE6, H2-KE6, SDR30C1 | 6p21.3 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | SDR36C1 | 4q34-q35 | |
| SPR | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) | SDR38C1 | 2p14-p12 | |
| CBR4 | carbonyl reductase 4 | FLJ14431, SDR45C1 | 4q32.3 | |
| HSD17B14 | hydroxysteroid (17-beta) dehydrogenase 14 | DHRS10 | retSDR3, SDR47C1 | 19q13.33 |
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| RDH11 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | MDT1, SDR7C1, ARSDR1 | 14q24.1 | |
| RDH12 | retinol dehydrogenase 12 (all-trans/9-cis/11-cis) | FLJ30273, SDR7C2, LCA13, RP53 | 14q24.1 | |
| RDH13 | retinol dehydrogenase 13 (all-trans/9-cis) | SDR7C3 | 19q13.42 | |
| RDH14 | retinol dehydrogenase 14 (all-trans/9-cis/11-cis) | PAN2, SDR7C4 | 2p24.2 | |
| DHRS13 | dehydrogenase/reductase (SDR family) member 13 | MGC23280, SDR7C5 | 17q11.2 | |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | BDH | SDR9C1 | 3q29 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | HSD17, SDR9C2 | 16q24.1-q24.2 | |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | SDR9C3 | 16q22 | |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | RDHL, 3alpha-HSD, RETSDR8, RDH15, SDR9C4 | 2q31.1 | |
| RDH5 | retinol dehydrogenase 5 (11-cis/9-cis) | RDH1 | HSD17B9, SDR9C5 | 12q13-q14 |
| HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 | HSE, RODH, SDR9C6 | 12q13.3 | |
| SDR9C7 | short chain dehydrogenase/reductase family 9C, member 7 | SDR-O, RDHS | 12q13.3 | |
| RDH16 | retinol dehydrogenase 16 (all-trans) | RODH-4, SDR9C8 | 12q13.3 | |
| HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 | EDHB17, EDH17B2 | HSD17, MGC138140, SDR28C1 | 17q11-q21 |
| HSD17B1P1 | hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 | EDHB17, EDH17B1, HSD17BP1 | SDR28C1P1 | 17q11-q21 |
| RDH8 | retinol dehydrogenase 8 (all-trans) | PRRDH, SDR28C2 | 19p13.2 | |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | PRAP, SDR37C1 | 1q23 | |
| DHRS12 | dehydrogenase/reductase (SDR family) member 12 | FLJ13639, SDR40C1 | 13q14.3 | |
| WWOX | WW domain containing oxidoreductase | FOR, WOX1, SDR41C1 | 16q23.3-q24.1 |
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| HSD17B4 | hydroxysteroid (17-beta) dehydrogenase 4 | MFE-2, DBP, SDR8C1 | 5q2 | |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | KAR, SDR12C1 | 11q11 | |
| HSD17B3 | hydroxysteroid (17-beta) dehydrogenase 3 | SDR12C2 | 9q22 | |
| HSDL1 | hydroxysteroid dehydrogenase like 1 | SDR12C3 | 16q24 | |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | retSDR1, Rsdr1, SDR1, RDH17, SDR16C1 | 1p36.1 | |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | DHRS8 | RetSDR2, 17-BETA-HSD11, 17-BETA-HSDXI, PAN1B, SDR16C2 | 4q22.1 |
| HSD17B13 | hydroxysteroid (17-beta) dehydrogenase 13 | SCDR9, SDR16C3 | 4q22.1 | |
| RDH10 | retinol dehydrogenase 10 (all-trans) | SDR16C4 | 8q21.11 | |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | RDHE2, RDH-E2 | 8q12.1 | |
| SDR16C6P | short chain dehydrogenase/reductase family 16C, member 6, pseudogene | SDR16C6 | 8q12.1 | |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | HSD11B, HSD11 | SDR26C1 | 1q32-q41 |
| HSD11B1L | hydroxysteroid (11-beta) dehydrogenase 1-like | SCDR10, SDR26C2 | 19p13.3 | |
| DHRS7B | dehydrogenase/reductase (SDR family) member 7B | DKFZp566O084, MGC8916, CGI-93, SDR32C1 | 17p12 | |
| DHRS7C | dehydrogenase/reductase (SDR family) member 7C | SDR32C2 | 17p13.1 | |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | retDSR4, SDR34C1 | 14q23.1 | |
| KDSR | 3-ketodihydrosphingosine reductase | FVT1 | DHSR, SDR35C1 | 18q21 |
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| GALE | UDP-galactose-4-epimerase | SDR1E1 | 1p36-p35 | |
| TGDS | TDP-glucose 4,6-dehydratase | TDPGD, SDR2E1 | 13q32.1 | |
| GMDS | GDP-mannose 4,6-dehydratase | GMD, SDR3E1 | 6p25 | |
| TSTA3 | tissue specific transplantation antigen P35B | FX, P35B, SDR4E1 | 8q24.3 | |
| UXS1 | UDP-glucuronate decarboxylase 1 | FLJ23591, UGD, SDR6E1 | 2q12.2 | |
| HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | HSDB3, HSD3B | SDR11E1 | 1p12 |
| HSD3B2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | SDR11E2 | 1p12 | |
| HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | C(27)-3BETA-HSD, SDR11E3 | 16p11.2 | |
| TDH | L-threonine dehydrogenase | FLJ25033, SDR14E1P | 8p23.1 | |
| NDUFA9 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa | NDUFS2L | SDR22E1, CI-39k | 12p13.3 |
| MAT2B | methionine adenosyltransferase II, beta | MATIIbeta, SDR23E1 | 5q34-q35 | |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | XAP104, H105e3, SDR31E1 | Xq28 | |
| SDR42E1 | short chain dehydrogenase/reductase family 42E, member 1 | HSPC105 | 16q23.3 | |
| SDR42E2 | short chain dehydrogenase/reductase family 42E, member 2 | 16p12.1 |
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| FAR1 | fatty acyl CoA reductase 1 | MLSTD2 | FLJ22728, SDR10E1 | 11p15.2 |
| FAR2 | fatty acyl CoA reductase 2 | MLSTD1 | FLJ10462, SDR10E2 | 12p11.23 |
| FASN | fatty acid synthase | FAS, SDR27X1 | 17q25 | |
| QDPR | quinoid dihydropteridine reductase | DHPR, PKU2, SDR33C1 | 4p15.31 | |
| SDR39U1 | short chain dehydrogenase/reductase family 39U, member 1 | C14orf124 | HCDI | 14q12 |
| BLVRB | biliverdin reductase B (flavin reductase (NADPH)) | FLR | SDR43U1 | 19q13.1-q13.2 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | TIP30, CC3, FLJ26963, SDR44U1 | 11p15.1 | |
| NMRAL1 | NmrA-like family domain containing 1 | FLJ25918, HSCARG, SDR48A1 | 16p13.3 |
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