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    Neuron. 2012 May 24;74(4):719-30. doi: 10.1016/j.neuron.2012.03.032.

    BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures.

    Giménez-Cassina A, Martínez-François JR, Fisher JK, Szlyk B, Polak K, Wiwczar J, Tanner GR, Lutas A, Yellen G, Danial NN.

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    Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

    Abstract

    Neuronal excitation can be substantially modulated by alterations in metabolism, as evident from the anticonvulsant effect of diets that reduce glucose utilization and promote ketone body metabolism. We provide genetic evidence that BAD, a protein with dual functions in apoptosis and glucose metabolism, imparts reciprocal effects on metabolism of glucose and ketone bodies in brain cells. These effects involve phosphoregulation of BAD and are independent of its apoptotic function. BAD modifications that reduce glucose metabolism produce a marked increase in the activity of metabolically sensitive K(ATP) channels in neurons, as well as resistance to behavioral and electrographic seizures in vivo. Seizure resistance is reversed by genetic ablation of the K(ATP) channel, implicating the BAD-K(ATP) axis in metabolic control of neuronal excitation and seizure responses.

    Copyright © 2012 Elsevier Inc. All rights reserved.

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    PMID:
    22632729
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3361694
    [Available on 2013/5/24]

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