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Reviewed April 2012
What is the official name of the NOG gene?
The official name of this gene is “noggin.”
NOG is the gene's official symbol. The NOG gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the NOG gene?
The NOG gene provides instructions for making a protein called noggin. This protein is involved in the development of many body tissues, including nerve tissue, muscles, and bones. Noggin's role in bone development makes it important for proper joint formation.
Noggin interacts with members of a group of proteins called bone morphogenetic proteins (BMPs). These proteins help control the development of bone and other tissues. In order to begin these developmental processes, BMPs attach (bind) to other proteins called receptors, and this binding stimulates specific cellular processes. The noggin protein regulates the activity of certain BMPs by attaching to them and blocking them from binding to the receptor, which leads to a decrease in BMP signaling.
How are changes in the NOG gene related to health conditions?
Where is the NOG gene located?
Cytogenetic Location: 17q22
Molecular Location on chromosome 17: base pairs 54,671,059 to 54,672,950
The NOG gene is located on the long (q) arm of chromosome 17 at position 22.
More precisely, the NOG gene is located from base pair 54,671,059 to base pair 54,672,950 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about NOG?
You and your healthcare professional may find the following resources about NOG helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the NOG gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding NOG?
acids ; amino acid ; ankylosis ; big toe ; bone formation ; brachydactyly ; carpal bones ; cell ; gene ; joint ; mutation ; protein ; proximal ; receptor ; sign ; spectrum ; stapes ; symptom ; syndactyly ; syndrome ; tissue ; vertebra
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.