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Osteoarthritis Initiative

Updated February 4, 2013

The Osteoarthritis Initiative (OAI) is a multicenter, longitudinal, prospective observational study of knee osteoarthritis (OA). This Initiative is a public-private partnership between the National Institutes of Health (NIH) and private industry that seeks to improve diagnosis and monitoring of osteoarthritis (OA) and foster development of new treatments. The overall aim of the OAI is to develop a public-domain research resource to facilitate the scientific evaluation of biomarkers for osteoarthritis as potential surrogate endpoints for disease onset and progression. For more details and the most recent information on the study, please see the "Osteoarthritis Initiative Updated Summary."

• OA Initiative Updated Summary, January 7, 2013
• OAI Organizational Structure (JPG file 92 KB)
• OAI Worldwide Data Users (JPG file 90 KB)
• News and Press Releases
• Recent Meetings and Activities
• Biospecimens
• Historical Meetings

News and Press Releases

Announcement January 7, 2013: Availability of 60-month images and clinical data from the OAI

Announcement June 24, 2010: Availability of Central Image Assessments of OAI MR Images

Announcement June 15, 2010: Awards of Ancillary and Complementary Research to the Osteoarthritis Initiative

Announcement March 8, 2010: Availability of 36-month images and clinical data from the OAI

Announcement January 13, 2009: Osteoarthritis Initiative Biospecimen Availability

Announcement September 13, 2007: OAI Announces Availability of New Data and Images

Press Release August 1, 2006: Osteoarthritis Initiative Releases First Data

Press Release March 17, 2004: Enrollment Begins for Osteoarthritis Initiative

Press Release August 13, 2002: Sites Chosen for Public-Private Osteoarthritis Initiative

Press Release Public-Private Consortium Launches Osteoarthritis Initiative, July 17, 2001

Recent Meeting and Activities

OAI Biospecimens

• Biospecimens Access Policy and Procedures Statement
• Biospecimens Study Application Guide
• Form Biospecimen Request (PDF version 872 KB)

Historical Items

Ancillary and Complementary Research to the Osteoarthritis Initiative

• Description of Solicitation
• Osteoarthritis, Patient Centered Outcomes and Complementary and Alternative Therapy (CAM)
• Pivotal Osteoarthritis Initiative Magnetic Resonance Imaging Analyses (POMA)
• Hip Morphology and Limb-Specific Risk Factors for Radiographic Hip Osteoarthritis

OAI Evaluation Meeting

June 2, 2008

• Introduction
• Rationale for Extension of OAI follow-up
• Participants Roster
• Agenda
• Meeting Summary

OA Risk Factor Meeting

October 3, 2008

• Introduction
• Participants Roster
• Agenda
• Meeting Summary

OA Initiative Prospectus

• August 29, 2000
• Introduction
• Prospectus
• Appendix A
• Appendix B
• Appendix C
• Appendix D
  
  

February 28-29, 2000 Meeting

• Notice of Meeting of The Osteoarthritis Initiative
• Agenda
• Participants Roster
• Meeting Summary
• Appendix A: The U.S. Longitudinal Studies of Osteoarthritis
• Appendix B: The European Longitudinal Studies of OA
• Additional International Osteoarthritis Epidemiology Studies
• Surrogate "White" Paper on Imaging: Summary of January 11, 2000 Imaging Meeting