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Tumor suppressor gene

Synonym(s)

  • antioncogenes
  • anti-oncogenes
  • emerogenes
  • genes, cancer suppressor
  • genes, onco-suppressor
  • genes, tumor suppressor
  • oncosuppressor gene
  • tumor suppressing genes

Definition(s)

Genes in the body that can suppress or block the development of cancer.

Definition from: Physician Data Query via Unified Medical Language SystemThis link leads to a site outside Genetics Home Reference. at the National Library of Medicine

Genes that normally restrain cell growth but, when missing or inactivated by mutation, allow cells to grow uncontrolled.

Definition from: Office of Rare DiseasesThis link leads to a site outside Genetics Home Reference. at the National Institutes of Health

A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division. The tumor suppressor protein plays a role in keeping cell division in check. When mutated, a tumor suppressor gene is unable to do its job, and as a result uncontrolled cell growth may occur. This may contribute to the development of a cancer.

Definition from: Talking Glossary of Genetic TermsThis link leads to a site outside Genetics Home Reference. from the National Human Genome Research Institute

See also Understanding Medical Terminology.

 
Published: February 25, 2013