Computational Toxicology Research
EPA's Computational Toxicology research (CompTox) is part of EPA's broader Chemical Safety research efforts. Traditional chemical toxicity testing is expensive, time consuming and uses a significant number of animals. CompTox is researching new, more efficient, ways to address managing the safety of chemicals, particularly in assessing chemicals for potential risk to human health and the environment. Read More
System Models for Chemical Toxicity and Exposure
Researchers collect new types of data on the biological effects of large numbers of untested chemicals using innovative technologies such as automated-rapid chemical screening. Virtual models are being developed to predict the body's potential responses to different chemicals.
Dashboards, Models and Tools
Researchers provide sophisticated models, databases and tools that are used to inform chemicals related regulatory and policy decisions.
Inherent Chemical Properties
The Distributed Structure – Searchable Toxicity (DSSTox) network is helping to build a public data foundation for improved chemical structure-activity and predictive toxicology capabilities.
Chemical Safety Research Grants & Funding
EPA's Science to Achieve Results or STAR program provides funding to research centers in specific areas of chemicals related research.
CompTox Research in the News
09.01.12 Scientists Magazine interviews Dr. Hunter about using stem cells to screen for toxicity 
06.12.12 Federal Radio Interviews NCCT Deputy about CompTox
03.21.12 Scientific American Highlights Tox21 Chemical Testing
03.12.12 Green is Good Interviews NCCT Director about ToxCast
02.20.12 Tox21 Robot Featured in Discover Magazine
01.29.12 V-Liver Discussed on Talking Points Memo
12.15.11 NY Times reports on Tox21
Press Releases
EPA Seeking Contract Proposals for Developing Developmental Toxicity Models using ToxCast
EPA issued a request for proposals for contractors to develop innovative developmental toxicity models using high throughput screening data from its Toxicity Forecaster (ToxCast) research effort. There is a pre-proposal conference September 19, 2012 at 1:30 PM ET. Proposals are due October 12, 2012 at 2 PM.
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EPA Awards Almost $11 Million to Advance Chemical Safety Research
EPA announced nearly $11 million in grants to eight universities to develop fast and effective methods to predict a chemical's potential to interact with biological processes that could lead to reproductive and developmental problems, and disruption of the endocrine system.
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U.S. EPA and L'Oreal announce research collaboration in San Francisco that may help end animal testing
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EPA, along with Tox 21 partners, releases list of 10,000 chemicals being screened by robot system
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President Obama Honors Outstanding Early-Career EPA CompTox Researcher Dr. David Reif
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Fact Sheets
- Using ToxCast to Test for Potential Endocrine Activity of Chemicals Case Study (pdf, 2pp, 125kb)
- ToxCast Models (pdf, 2pp, 213kb)
- Combining Toxcast, Dosimetry and Human Exposure Research (pdf, 2pp, 171kb)
- CompTox Research Program (pdf, 2pp, 922kb)
- High-Throughput Risk Assessment (pdf, 2pp, 0.17mb)
- ToxCast™ (pdf, 2pp , 0.5mb)
- ToxCast Dosimetry & Exposure (pdf, 2pp, 0.34mb)
- Toxicological Priority Index (pdf, 2pp, 0.15mb)
- Chemical Toxicity Database (pdf, 2pp, 0.24mb)
- ToxCast Oil Spill Dispersant Analysis (pdf, 2pp, 0.08mb)
- Virtual Tissues (pdf, 2pp, 0.32mb)