Director's Report to the National Advisory Council on Drug Abuse
September, 2001
Program Activities
New NIDA PAs and RFAs
On May 21, 2001, NIDA issued a Program Announcement entitled Drug Abuse Health Services Research (PA-01-097). This PA replaces in its entirety PA-94-047 published in the NIH Guide, Vol. 23, No. 10 on March 11, 1994. Through this PA research is sought on the organization, management, and economics of drug abuse treatment and prevention services, and the effects of these factors on the quality, cost, access to, effectiveness and outcomes of care for drug abuse and addictive disorders. Additionally, this announcement seeks studies that examine the impact of the integration of HIV/AIDS and other services on outcomes.
PAs and RFAs Issued With Other NIH Components/Agencies
On May 16, 2001, NIDA, in collaboration with numerous other NIH components issued a Program Announcement entitled The Zebrafish as an Animal Model for Development and Disease Research (PA-01-095). The purpose of this PA is to solicit applications as part of an NIH initiative to increase our support of the zebrafish as an animal model for development, organ formation, behavior, aging, and disease research. This PA is a reissuance of PA-98-074 which was published in the NIH Guide for Grants and Contracts, Vol. 5, No. 22, on May 21, 1998. This effort stems from an NIH initiative with participation of numerous Institutes and Centers working through the Trans-NIH Zebrafish Coordinating Committee under the co-chairmanship of NICHD and NIDDK.
On May 21, 2001, NIDA and several other NIH components issued a Program Announcement entitled Behavioral, Social, Mental Health, and Substance Abuse Research With Diverse Populations (PA-01-096). Through this PA, sponsoring NIH components invite submission of grant applications for behavioral, social, mental health, and substance abuse research with lesbian, gay, bisexual, transgendered, and related populations (LGBT populations). This PA was developed in response to recommendations produced at a workshop on "New Approaches to Research on Sexual Orientation, Mental Health, and Substance Abuse" which took place on September 27-28, 1999, under the co-sponsorship of NIMH, NIDA, OBSSR and ORWH.
On July 31, 2001, NIDA and NIMH jointly issued a Program Announcement entitled Collaborative R01s for Clinical and Services Studies of Mental Disorders and AIDS (CSMD) (PA-01-123). The purpose of this PA is to support collaborative intervention trials and other clinical and services studies at two or more sites. The studies typically share a specific protocol across the sites and are organized in order to increase sample size, accelerate recruitment, or increase sample diversity and representation. Each site has its own PI and the program provides a mechanism for cross-site coordination, quality control, database management, statistical analysis, and reporting. This PA supercedes PAR-98-017 published December 19, 1997.
On June 25, 2001, NIDA, in collaboration with a number of other NIH components, issued an RFA entitled International Tobacco and Health Research and Capacity Building Program (RFA-TW-02-005). This RFA solicits research and capacity building projects that address the burden of tobacco consumption in low- and middle- income nations by 1) pursuing observational, intervention and policy research of local relevance and 2) building capacity in these regions in epidemiological and behavioral research, prevention, treatment, communications, health services and policy research. Letter of Intent Receipt Date for this RFA is September 4, 2001; Application Receipt Date is October 26, 2001.
On July 25, 2001, NIDA in collaboration with a number other NIH components, issued an RFA entitled Clinical Research Education and Career Development in Minority Institutions (RFA-AR-01-009). The purpose of this RFA is to support the development and implementation of curriculum-dependent programs in minority institutions to train selected doctoral and postdoctoral candidates in clinical research leading to a Master of Science in Clinical Research or Master of Public Health in a clinically relevant area. Letter of Intent Receipt Date for this RFA is December 17, 2001; Application Receipt Date is February 15, 2002.
On July 27, 2001, NIDA, in conjunction with several other NIH Institutes, issued an RFA entitled Cognitive Neuroimaging: Understanding the Link Between Neuronal Activity and Functional Imaging Signals (RFA-NS-02-009). This RFA invites research grant applications that offer the promise of exceptional technical and conceptual advances in our understanding of the nature of the signal being recorded in hemodynamic brain imaging techniques. Letter of Intent Receipt Date for this RFA is September 30, 2001; Application Receipt Date is November 28, 2001.
Other Program Activities
The Methamphetamine Clinical Program
To implement the recommendations of the Methamphetamine Addiction Treatment Think Tank (MATTT) meeting held in January, a process was started to establish a group of sites to conduct clinical trials for methamphetamine dependents patients. Five sites have been selected where the epidemic is currently concentrated, two in the Midwest (Des Moines, Iowa, and Kansas City, Kansas), and the other three are Los Angeles, San Diego, CA, and Honolulu, HI. The first study is a behavioral pilot study where three times a week cognitive based group therapy is offered and data on withdrawal symptoms and methamphetamine urine PK data will be obtained. This will be followed by the first medication study protocol that is approved by FDA (ondansetron) and will be sent to local IRBs for review. This study is projected to start in October 2001. Additionally, selegiline and bupropion will be studied first in inpatient clinical pharmacology studies at UCLA, UTSA and UCSF for safety interactions with amphetamine. Following these studies, and if safety is not an issue, selegiline and bupropion will be advanced to outpatient studies. More safety interaction studies are planned for reserpine. Plans are underway to obtain lobeline from a pharmaceutical manufacturer to study its safety profile with amphetamine and ultimately also advance it to outpatient studies.
Clinical Research Efficacy Screening Trial (CREST-II) Study
In April 2001 a group of outside consultants reviewed the data from each NIDA/VA Medications Development Research Unit (MDRU) in their CREST studies (eight medications total and an unmatched placebo). Out of the 8 medications reviewed two medications (tiagabine, a GABA uptake inhibitor, anti-seizure medication, and Sertraline, an SSRI antidepressant) were shown to give trends toward positive signals in these screening pilot studies. The recommendations of the consultants were to follow up with larger phase II studies on these medications.
Cocaine Clinical Trials Operations
This network of four academic clinical sites has been established to replace the old MDRU sites to conduct clinical trials for cocaine addiction. The sites are University of California, Los Angeles, University of Cincinnati, Medical University of South Carolina, and University of Texas at San Antonio. The contract is in place with two other supporting contracts with TRI and KAI for data management. Eight protocols have been submitted for the sites to study, three are phase one interaction studies (Modafinil, Metyrapone, Tolcapone) one is a phase IIa study (Ondansteron) and two are phase IIb studies (reserpine and cabergoline). These studies have been initiated and subject recruitment is underway.
GBR 12909 Study
The study report from the Phase I (healthy volunteer) study is complete and was reviewed by consultants in June 2001 in planning for a cocaine interaction study. The study showed 30-40% dopamine transporter occupancy at the 100mg dose level. Based on primate data showing equivalent levels of occupancy at doses reducing cocaine self-administration, this may be clinically meaningful in cocaine treatment. The consultants' recommendation was to follow up with an ADME study in cocaine dependent patients.
NS2359 Study
The study has started at the Uniformed Services University of the Health Sciences; the first dose cohort will be complete in September 2001 and will be reviewed by DSMB prior to proceeding to the next dose level.
Selegiline Study
The phase III 300 subject, 16 sites Selegiline Transdermal System study started and subject recruitment is underway.
Lofexidine for Heroin Withdrawal Study
This phase III multisite study protocol has started, and subject recruitment is underway.
CTN Protocol Update
For protocol CTN 0001, Buprenorphine/Naloxone for Detoxification in Inpatient Settings, two sites have begun enrollment, four additional sites will start in the next few months.
For protocol CTN 0002, Buprenorphine/Naloxone for Detoxification in Outpatient Settings, all six sites are enrolling patients. Total enrollment has reached about one-third of the total target enrollment.
For protocol CTN 0003, Buprenorphine/Naloxone: Comparison of Three Taper Schedules for Opiate Detoxification, fourteen sites across nine nodes is set to begin enrollment. Enrollment should begin this fall after IRB and other regulatory approvals are complete.
For protocol CTN 0004, Motivational Enhancement Therapy, one site has begun enrolling; five additional sites will be launched soon.
For protocol CTN 0005, Motivational Interviewing, four sites have begun enrollment, one additional site will start shortly.
For protocol CTN 0006, Motivational Incentives in Drug Free Clinics, five sites are currently enrolling patients; two additional sites will be active when fully launched.
For protocol CTN 0007, Motivational Incentives in Methadone Clinics, three sites are enrolling patients, another four sites will begin enrollment shortly.
The CTN nodes submitted 17 new research concepts as the 3rd Wave in March 2001. These concepts were subsequently reviewed by the CTN Concept Review Sub-committee, of the CTN Steering Committee. Nine concepts were selected and presented to the CTN Oversight Board for review on July 31, 2001. Approved Concepts will be further developed into protocols.
QT Prolongation Consultants Meeting
On September 5, the Medications Discovery & Toxicology Branch (MDTB) held a "QT Prolongation Consultants Meeting" at NIDA Headquarters in Rockville. During recent years, drug-induced QT prolongation has surfaced as a major issue in medications development; several drugs have been withdrawn from the market due to QT prolongation and the associated risk of fatal ventricular arrhythmias. As part of a more general effort to identify and drop "problem compounds" early in the preclinical discovery and development process, the MDTB has established subcontracts to conduct two different in vitro assays, the "HERG channel assay" and the "Purkinjie fiber action potential duration assay," both of which are claimed to be predictive of clinical QT prolongation problems. NIDA's consultants - Dr. Alan Stuart Bass (Schering Plough), Dr. Anthony Fossa (Pfizer), Dr. Gary Gintant (Abbott), Dr. Dustan (Eli Lilly), Dr. Peter Siegl (Merck) and Dr. Craig January (University of Wisconsin) - assisted NIDA in interpreting the initial data obtained from the two assays, which in several cases yielded conflicting predictions for the same compound. The meeting proved to be mutually beneficial to NIDA, the consultants, and FDA staff (attending in an observer role), all of whom are struggling to deal with the challenge of predicting QT prolongation problems through new, in vitro assays. Regulatory guidelines have not been established in this area. The meeting was organized by Drs. Naresh Chand, James Terrill and David McCann.
NIDA/VACSP #1018 Buprenorphine Best Practices Trial
Enrollment for the study closed on January 6, 2001 with a total of 583 patients being enrolled. Patients can participate up to one year from the date of their enrollment. The last patient should complete on February 6, 2002 (assuming 1 year participation and 30 day follow-up). 38 physicians' offices and 33 pharmacies participated.
33.8% of the patients enrolled were female. The mean age at baseline was 35.8 years (36.0 median) with a range of 15 to 66. As of May 21, 2001, 272 patients were still following the protocol. The main reasons for dropout were failure to return to clinic (63%) followed by the patient's request to discontinue (8.6%).
Meetings are currently being held with the data center, to finalize the data analyses to be performed, before the final dataset is obtained, in an effort to decrease the time to a final study report.
NIDA's New and Competing Grants Awarded Since May 2001
Agar, Michael H. -- Friends Research Institute
Trend Theory In Community Context
Akins, Chana K. -- University of Kentucky
A Visual Cue Model To Investigate Cocaine Reward
Andrews, Anthony R. -- Ohio University
High Speed Microscale Drug Screening of Saliva
Anglin, M.D. -- UCLA Drug Abuse Research Training Center
UCLA Integrated Substance Abuse Program
Anokhin, Andrey -- Washington University
Biobehavioral Markers of Risk for Nicotine Addiction
Arfken, Cynthia L. -- Wayne State University
Organizational Processes In Treatment Programs
Barr, Gordon A. -- Research Foundation for Mental Hygiene Inc.
Chronic Opiates During Ontogeny: A Microarray Analysis
Bartus, Raymond T. -- Alkermes, Inc.
Novel, Sustained-Release Naltrexone for Opiate Abuse
Baum, Marianna K. -- Florida International University
Zinc Therapy In Zinc Deficient HIV+ Drug Users
Beaudoin, Alison O. -- Yale University School of Medicine
Behavioral Effects of GHB In Healthy Volunteers
Berke, Joshua D. -- Boston University
Multiple Memory Systems In Action Selection
Bidlack, Jean M. -- University of Rochester
Pharmacology of Drug Abuse
Bigelow, George E. -- Johns Hopkins Bayview Medical Center
Human Behavioral Pharmacology of Substance Abuse
Blanco, Carlos -- Columbia University
Opioid Dependence and Pathological Gambling
Booze, Rosemarie M. -- University of Kentucky Medical Center
HIV/Cocaine Neurotoxicity In Females
Borsook, David -- Massachusetts General Hospital
CNS Reward/Aversion Circuitry Activated By Pain/Opioids
Brown, David R. -- University of Minnesota
Mucosal Defense Mechanisms In Substance Abuse
Brue, Vesta -- Lifetechniques, Inc.
Electronic Smoking Cessation Monitor and Communicator
Butler, Stephen F. -- Innovative Training Systems
A Spanish Adaption of the ASI-Multimedia Version
Carelli, Regina M. -- University of North Carolina at Chapel Hill
Neurophysiological Study: Cocaine and Natural Reinforcers
Carlson, Robert G. -- Wright State University
MDMA/Club Drug Use and STD/HIV Sex Risk Behavior In Ohio
Carroll, Frank I. -- Research Triangle Institute
Cocaine: A Study of the Biochemical Mechanism of Action
Catalano, Richard F. -- University of Washington
Reducing Risk and Enhancing Protective Factors In Children
Chiauzzi, Emil -- Inflession, Inc.
Multimedia Smoking Cessation for Alcoholic Clients
Childers, Steven R. -- Wake Forest University
Neuroscience of Drug Abuse Training Program
Clatts, Michael C. -- Columbia University of New York
HIV Risk Among MSM 'Speed' Injectors
Cohen, Mark S. -- UCLA Brain Mapping Center
Enabling Technologies In FMRI and Cigarette Smoking
Commons, Kathryn G. -- Children's Hospital of Philadelphia
Opioids and Stress: The PAG
Corodimas, Keith P. -- Lynchburg College
Adenosinergic Neuromodulation of Emotional Learning
Coscia, Carmine J. -- St. Louis University School of Medicine
Gestational Buprenorphine and Mesolimbic Systems Ontogeny
Crabbe, John C. -- Oregon Health Sciences University
Biological Bases of Drug Seeking Behavior
Dewey, William L. -- Virginia Commonwealth University
Training In the Pharmacology of Abused Drugs
Dishion, Thomas -- University of Oregon
Understanding and Preventing Adolescent Drug Abuse
Eiden, Rina D. -- Research Institute on Addiction
Maternal Substance Use and Toddler Self-Regulation
Ellinwood, Everett H. -- Duke University
Medication Development for Methamphetamine Abuse
Escoffery, Ngoc-Cam T. -- University of Georgia
Smoking Cessation Intervention for College Smokers
Fairbanks, Carolyn A. -- University of Minnesota
Endogenous Agmatine In Glutamatergic Pain Processing
Fals-Stewart, William S. -- Research Institute on Addiction
Brief Couples Therapy In Drug Abuse Treatment
Fiez, Julie A. -- University of Pittsburgh
FMRI Studies of the Neural Basis of Reward Processing
Flanigan, Timothy P. -- Miriam Hospital
HIV and Other Infectious Consequences of Substance Abuse
Flewelling, Robert L. -- Pacific Institute for Research
National Study of Risk Factors for Adolescent Drug Use
Flores, Christopher M. -- University of Texas Health Science Center
Mechanisms of Nicotine-Induced Neurogenic Inflammation
Foster, E. M. -- Oregon Research Institute
School-Wide Prevention of Risk Factors for Drug Abuse
Frost, Douglas O. -- University of Maryland, Baltimore
Effects of M-Amphetamine on Neural Circuit Development
Frost, James J. -- Johns Hopkins University
Brain Opioid Receptors and Cognition In Cocaine Abuse
Gatley, John S. -- Brookhaven National Laboratory
Brain Imaging and Drug Abuse
Gebo, Kelly A. -- Johns Hopkins University School of Medicine
Improving Health Care Utilization In HIV+ Drug Users
Gelberg, Lillian -- UCLA Center for Health Sciences
Hepatitis B and C Among Homeless Adults
Gibb, James W. -- University of Utah
Differential Effects of Methamphetamine and Cocaine
Girdler, Susan S. -- University of North Carolina at Chapel Hill
Gender,Nicotine and Stress-Induced Analgesia
Gollub, Erica L. -- University of Pennsylvania
Empowering Women Drug Users To Reduce HIV Risk
Gonzalez-Haddad, Gerardo -- Yale University School of Medicine
Comorbid Disorders In Treatment of Opiate Dependence
Graham, Camilla S. -- Beth Israel Deacones Medical Center
Cellular Immunity to Hepatitis C Virus In HIV
Green, William M. -- University of Chicago
Upregulation of Nicotinic Receptors
Grobe, James E. -- University of Kansas
Smoking Controllability/Moderation of Tobacco Effects
Guydish, Joseph R. -- University of California-San Francisco
Integrating Multi-Assessment Into Practice
Hackett, Perry -- University of Minnesota
Insertional Mutagenesis In Zebrafish By Sb Transposons
Hatsukami, Dorothy K. -- University of Minnesota Medical School
Treatment of Smokeless Tobacco Users
Higgins, Stephen T. -- University of Vermont
Voucher-Based Incentives To Treat Pregnant Smokers
Hinkin, Charles H. -- UCLA/NPI
Predictors: Medication Adherence In HIV+ Cocaine Abusers
Hohmann, Andrea G. -- University of Georgia
Endocannabinoid Mechanisms of Stress-Induced Analgesia
Howell, Leonard L. -- Emory University
PET Imaging and Cocaine Neuropharmacology In Monkeys
Huang, Li-Yen M. -- University of Texas Medical Branch
Opioid Receptor Gene Transfer-Pain and Tolerance
Hunt, Geoffrey P. -- Scientific Analysis Corp.
The Social World of Club Drugs: A Qualitative Study
Javitt, Daniel C. -- Nathan Kline Psychiatric Institute
Phencyclidine Abuse and Psychoses: Biomedical Mechanisms
Jennings, Peggy J. -- University of Wyoming
Cognitive Consequences of the Stress Response
Kharasch, Evan D. -- University of Washington
Methadone and HIV Drug Interactions
Khodakhah, Kamran -- University of Colorado Health Science Center
Regulation of Neuronal Excitability By Calcium Release
Kimberg, Daniel Y. -- University of Pennsylvania
A Flexible Architecture For Neuroimaging Data Analysis
Kleber, Herbert D. -- New York State Psychiatric Institute
Improving Drug Abuse Treatment By Research and Training
Ko, Mei-Chuan -- University of Michigan
Intrathecal Opioid-Induced Pruritus
Kornetsky, Conan -- Boston University School of Medicine
Opiate Abuse, Reward and Aging
Kosofsky, Barry E. -- Massachusetts General Hospital
Cocaine-Induced Disturbances of Mouse Brain Development
Kosten, Thomas R. -- Yale University
Pharmacotherapy for Opioid and Cocaine Dependence
Kuhar, Michael J. -- Emory University
Cart: A Novel Cocaine Regulated Neurochemical
Landau, Nathaniel R. -- Salk Institute for Biological Studies
Murine Model for HIV-1 Replication
Latimer, William W. -- Johns Hopkins University
Neurobehavioral Model of HIV In Injection Drug Users
Law, Ping-Yee -- University of Minnesota
G Proteins and Opioid Receptor Functions
Levitt, Pat R. -- University of Pittsburgh
Brain Structure and Function After Fetal Cocaine Exposure
Liberty, Hilary J. -- Social Sciences Innovations Co.
Self-Report/Biological Measures Database of Drug Use
Ling, Walter -- Friends Medical Research Center
Pain Analgesic Response In Opiate Dependence
Lipsey, Mark W.-- Vanderbilt University
Meta-Analysis of Risk For Substance Use
Lord, Sarah E. -- Innovative Training Systems
Multimedia Addiction Severity Index for Adolescents
Luedtke, Robert R. -- University of North Texas
Mapping the D2/D3 Dopamine Receptor Binding Sites
Lupica, Carl R. -- University of Arizona
The Functional Neurobiology of Cannabinoids In Brain
Macaulay, Araxi -- National Health Promotion Assoc., Inc.
Life Skills Training Parent Component
Mackie, Kenneth P. -- University of Washington
Cannabinoid Modulation of Neuronal Function
Mannuzza, Salvatore -- New York University School of Medicine
Childhood Stimulant Treatment and Adult Substance Abuse
Mao, Jianren -- Massachusetts General Hospital
Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
Martin, Billy R. -- Virginia Commonwealth University
Center for Drug Abuse Research
Mayhan, William G. -- University of Nebraska Medical Center
Nicotine-Induced Cerebrovascular Dysfunction
Meisch, Richard A. -- University of Texas Houston Health Science Center
Drug Reinforcing Effects
Mendelson, Jack H. -- McLean Hospital
Drug Abuse Research Training Program
Miller, Gregory A. -- University of Illinois
Neurocognitive Mechanisms: Appetitive and Aversive Emotion
Molitor, Thomas W. -- University of Minnesota
Training In Neurobehavior/Neuroimmune Addiction Research
Molliver, Mark E. -- Johns Hopkins University School of Medicine
Drug Addiction: Dual 5-HT Innervation of Limbic System
Monterosso, John -- University of Pennsylvania
Brain Substrates of Self-Control In Addiction
Morgan, Michael M. -- Washington State University
Contribution of the PAG To Morphine Tolerance
Morris, Martina W. -- Pennsylvania State University
Modeling HIV and STD In Drug User and Sexual Networks
Morrow, Lisa A. -- Western Psychiatric Institute
WTW Clients: Substance Abuse and Neuropsychiatric Function
Morse, Edward V. -- Tulane University Health Sciences Center
Risk Reduction for Young African American IDUs
Nemoto, Tooru -- University of California, San Francisco
HIV Risk Reduction Among Asian Women
Neumeyer, John L. -- McLean Hospital
Mixed Kappa/MU Opioids: Synthesis and Evaluation
Nunes, Edward V. -- Columbia University
Drug Abuse Pharmacotherapy: Methodologic Initiatives
Odum, Amy -- University of New Hampshire
Effects of Drugs In An Animal Model of Relapse
Orwin, Robert G. -- Westat, Inc.
Specialized Treatment for Women and Children
Perrine, M. W. -- Addiction Research Institute
Drugs, Alcohol, and Driving: Prevalence and Crash Risk
Pickett, Kate E. -- University of Chicago
Patterns of Maternal Smoking During Pregnancy
Polgar, Michael -- Washington University
Families As Partners In Homeless Drug Abuse Services
Porrino, Linda J. -- Wake Forest University School of Medicine
Neurobiological Correlates of Cocaine Abuse
Potts, Geoffrey F. -- Rice University
ERP Studies of Neural Systems of Salience Evaluation
Powell, Jane H. -- Goldsmiths College
Smoking Cessation, Reward Motivation And Impulsivity
Pricheps, Leslie S. -- NYU School of Medicine
Biobehavioral Heterogeneity of Crack Cocaine Dependence
Quick, Michael W. -- FASEB
New Perspectives In Transporter Biology-FASEB Conference
Quick, Michael W. -- University of Alabama at Birmingham
GABA Transporters: Trafficking and Regulation
Richards, Jerry B. -- State University of New York at Buffalo
Drug Abuse and Impulsivity : Tests of Animal Models
Riley, William T. -- Pics, Inc.
Computerized Scheduling of Nicotine Nasal Spray
Risinger, Robert C. -- Medical College of Wisconsin
Neural Substrates of Human Cocaine Self-Administration
Robinson, Terry E. -- University of Michigan
Neural Basis of Behavioral Sensitization
Robinson, Terry E. -- University of Michigan
The Influence of Drugs of Abuse on Neuronal Morphology
Roffman, Roger A. -- University of Washington
Reaching and Motivating - Change In Teen Marijuana Smokers
Roll, John M. -- Friends Research Institute
Adolescent Smoking Cessation
Rollins, Douglas E. -- University of Utah
Disposition of Drugs of Abuse In Hair
Rowlett, James K. -- Harvard Medical School
Nonhuman Primate Model of Benzodiazepine Relapse
Rush, Craig R. -- University of Kentucky
GABA Agonists As Pharmacotherapies For Cocaine Abuse
Sayette, Michael -- University of Pittsburgh
Affective and Cognitive Processes In Smoking Craving
Schoffelmeer, Anton N. -- Free University
Gene Expression Patterns During Heroin Seeking Behavior
Schwarzschild, Michael A. -- Massachusetts General Hospital
A2a Adenosine Receptors In Psychostimulant Sensitization
Schweitzer, Paul P. -- Scripps Research Institute
Cannabinoids and Central Neuronal Activity
Sealfon, Stuart C. -- Mount Sinai School of Medicine
Interdisciplinary Training In Drug Abuse Research
Seeman, Philip -- University of Toronto
Receptors Mediating Drug Dependence
Segal, David S. -- University of California, San Diego
Behavioral Characterization of Acute and Chronic Amphetamine
Shapshak, Paul -- University of Miami School of Medicine
Gene Expression In HIV Associated Dementia Brain
Shibusawa, Tazuko -- Columbia University
HIV Risk Among Older African American/Latino Drug Users
Shimamura, Arthur P. -- University of California
Role of the Orbitofrontal Cortex In Regulating Emotion
Siegal, Harvey A. -- Wright State University
Crack and Health Service Use: A Natural History Approach
Siegel, Shepard -- McMaster University
Associative Contributions To Drug Tolerance
Simon, Eric J. -- New York University
Effects of Morphine and Analogues on Cell Metabolism
Sirevaag, Erik J. -- Washington University
Behavioral Genetics of Nicotine Dependence
Slotkin, Theodore A. -- Duke University Medical Center
Fetal and Adolescent Nicotine Effects on CNS 5ht Systems
Smagin, Gennady N. -- Louisiana State University Health Sciences Center
Neurochemistry of Cocaine Reinforcement
Stein, Michael D. -- Rhode Island Hospital
Midcareer Investigator Award In Substance Abuse Research
Stella, Nephi -- University of Washington School of Medicine
Cannabinoid Signaling System In Microglial Cell
Sterk, Claire -- Emory University
Young Adults and Drug Use: Careers and Familiar Factors
Stevens, Craig W. -- Oklahoma State University
Functional Evolution of Opioid Receptors
Stitzel, Jerry A. -- University of Michigan Medical Center
Identification of Functional Nachr Variants In Mice
Striley, Catherine W. -- Washington University
Culture In Congruence and Substance Treatment Access
Tashkin, Donald P. -- University of California, Los Angeles
Pulmonary Effects of Habitual Use of Marijuna
Traynor, John R. -- University of Michigan
Opioid Receptor Mechanisms
Tseng, Leon F. -- Medical College of Wisconsin
Role Of Endogenous Opioid Peptides In Opioid Addiction
Tsibulsky, Vladimir -- University of Cincinnati
Measurement of Priming and Satiety Thresholds In Mice
Wagstaff, John D. -- Cognetix, Inc.
Cgx-1160, A Non-Opioid, Broad-Spectrum Analgesic
Weeks, Margaret R. -- Institute for Community Research
HIV Prevention In High Risk Drug Use Sites: Project Rap
Weisner, Constance M. -- University of California, San Francisco
Integrated Drug and Medical Care-Cost and Effectiveness
Williams, Jill M.-- University of Medicine & Dentistry of New Jersey
Nicotine Dependence Treatment In Psychiatric Comorbidity
Williams, Mark L. -- University of Texas Health Sciences Center, Houston
A Test of Peer Delivered Self-Efficacy Intervention
Winder, Danny G. -- Vanderbilt University Medical Center
Regulation of LTP By GI-Linked Receptors
Wong, Frank Y. -- George Washington University
Substance Use/HIV In 3 DC Southeast Asian Communities
Woods, James H. -- University of Michigan Medical School
BCHE As A Cocaine Antagonist
Worley, Paul F. -- Johns Hopkins University School of Medicine
Effector Ieg, Homer and Drug Addiction
Wyrick, David L.-- Graduate School of Education
School-Based Use of the Posit
Zvartau, Edwin E. -- Pavlov Medical University
Intravenous Self-Administration In Drug-Naive Mice
[Office
of the Director][Report Index][Next
Report Section]
|
