HomoloGene is a system for automated detection of homologs among the annotated genes of several completely sequenced eukaryotic genomes.

HomoloGene Release 66 Statistics



Initial numbers of genes from complete genomes, numbers of genes placed in a homology group, and the numbers of groups for each species.

Species   Number of Genes   HomoloGene
  Input Grouped   groups
H.sapiens 19,565* 19,088   18,631
P.troglodytes 21,415* 18,364   17,945
M.mulatta 22,566* 17,265   16,841
C.lupus 19,176* 17,802   17,187
B.taurus 21,121* 18,785   17,472
M.musculus 22,513* 21,271   19,027
R.norvegicus 21,943* 19,930   17,950
G.gallus 16,731* 14,172   13,150
D.rerio 26,326* 20,516   14,192
D.melanogaster 13,663* 9,273   7,731
A.gambiae 12,460  8,833   7,508
C.elegans 20,185  8,698   4,817
S.cerevisiae 5,882* 4,853   4,372
K.lactis 4,978  4,404   4,338
A.gossypii 4,722  3,931   3,887
S.pombe 5,018  3,240   2,948
M.oryzae 12,832  7,328   6,400
N.crassa 9,821  6,299   6,156
A.thaliana 27,388* 19,983   11,092
O.sativa 64* 17,085   10,436
P.falciparum 5,029  2,031   779


'*' indicates organisms where new genome annotation data is used in this build.


Last updated on: Mon Apr 16 2012



We have recently adopted a new build procedure that makes use of amino acid sequence searching (blastp) to find more distant relationships, but the procedure still refers to the DNA sequence for computation of some of the statistics. The matching strategy is guided by the taxonomic tree such that more closely related organisms are compared first. Moreover, HomoloGene entries now include paralogs in addition to orthologs.




Sources of Additional Information



HomoloGene entries have been augumented with homology and phenotype information drawn from the following sources.

Online Mendelian Inheritance in Man (OMIM)

Mouse Genome Informatics (MGI)

Zebrafish Information Network (ZFIN)

Saccharomyces Genome Database (SGD)

FlyBase

 

What's New
Macaca mulatta (Rhesus monkey) has been added for release 66 of HomoloGene and gene sets for several other species have been updated.



Related Resources
Protein Clusters

List of Genomes

Taxonomy