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Updated Pediatric ARV Guidelines

Updates to the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection were released on Thursday, November 1, 2012. Please send your comments to ContactUs@aidsinfo.nih.gov by November 15, 2012.

Corrections were made to the guideline. For a description of the changes, please see the correction notice.

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Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

Appendix B: Acronyms

(Last updated:11/1/2012; last reviewed:11/1/2012)

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3TC = lamivudine

AAP = American Academy of Pediatrics
ABC = abacavir
ALT = alanine aminotransferase
ANC = absolute neutrophil count
ART  = antiretroviral therapy
             antiretroviral treatment
ARV = antiretroviral
AST = aspartate aminotransferase
ATV  = atazanavir
ATV/r  = atazanavir/ritonavir
AUC = area under the curve
AV = atrioventricular

BMD = bone mineral density
BMI = body mass index
BUN = blood urea nitrogen

cART = combination antiretroviral therapy
CBC = complete blood count
CDC = Centers for Disease Control and Prevention
CHER Trial = The Children with HIV Early Antiretroviral Therapy Trial
CHIPS = Collaborative HIV Pediatric Study
CK = creatine kinase
Cmax = maximum plasma concentration
Cmin = minimum plasma concentration
CMV = cytomegalovirus
CNS = central nervous system
COBI = cobicistat
CPK = creatine phosphokinase
CrCl = creatinine clearance
CT = computed tomography
          continuous therapy
CVD = cardiovascular disease
CYP = cytochrome P

d4T = stavudine
ddI = didanosine
DM = diabetes mellitus
D/M = dual-mixed (tropic)
DMPA = depot medroxyprogesterone acetate
DOT = directly observed therapy
DRESS = drug rash with eosinophilia and systemic symptoms
DRV = darunavir
DXA = dual-energy x-ray absorptiometry

EBV = Epstein-Barr virus
EC = enteric-coated
ECG = electrocardiogram
EFV = efavirenz
ELISA = enzyme-linked immunosorbent assay
EM = erythema multiforme
ENV = enfuvirtide
ETR = etravirine
EVG = elvitegravir

FDA = Food and Drug Administration
FPG = fasting plasma glucose
FPV = fosamprenavir
FTC = emtricitabine
FXB = François-Xavier Bagnoud Center

G6PD = glucose-6-phosphate dehydrogenase
G-CSF = granulocyte colony-stimulating factor
GGT = gamma glutamyl transpeptidase
GI = gastrointestinal
GIQ = genotypic inhibitory quotient

HAART = highly active antiretroviral therapy
HAV = hepatitis A virus
HBV = hepatitis B virus
HCV = hepatitis C virus
HDL = high-density lipoprotein
HDL-C = high-density lipoprotein cholesterol
Hgb = hemoglobin
HHS = U.S. Department of Health and Human Services
HIVMA = HIV Medicine Association
HPPMCS = HIV Paediatric Prognostic Markers Collaborative Study
HRSA = Health Resources and Services Administration
HSR = hypersensitivity reaction
HSV = herpes simplex virus

IAS-USA = International Antiviral Society-USA
IC50 = mean inhibitory concentration
ICH = intracranial hemorrhage
IDSA = Infectious Diseases Society of America
IDV = indinavir
IFA assay = immunofluorescent antibody assay
IgE = immunoglobulin E
INSTI = integrase strand transfer inhibitor
IQ = inhibitory quotient
IRIS = immune reconstitution inflammatory syndrome
IU = international units
IUD = intrauterine device
IV = intravenous/intravenously
IVIG = intravenous immune globulin

LDL = low-density lipoprotein
LDL-C = low-density lipoprotein cholesterol
LFT = liver function test
LIP = lymphoid interstitial pneumonia
LPV = lopinavir
LPV/r = lopinavir/ritonavir

MAC = Mycobacterium avium complex
m-DOT = modified directly observed therapy
MEMS = Medication Event Monitoring System
MRI = magnetic resonance imaging
msec = milliseconds
MTCT = mother-to-child transmission
MVC = maraviroc

NA-ACCORD = North American AIDS Cohort Collaboration on Research and Design
NFV = nelfinavir
NIH = National Institutes of Health
NNRTI = non-nucleoside reverse transcriptase inhibitor/non-nucleoside analogue reverse transcriptase inhibitor
NRTI = nucleoside reverse transcriptase inhibitor/nucleoside analogue reverse transcriptase inhibitor
NVP = nevirapine

OARAC = Office of AIDS Research Advisory Council
OBR = optimized background regimen
OBT = optimized background therapy
OGTT = oral glucose tolerance test
OI = opportunistic infection

PBMC = peripheral blood mononuclear cells
PCP = Pneumocystis jirovecipneumonia
PCR = polymerase chain reaction
PENTA = Paediatric European Network for Treatment of AIDS
PG = plasma glucose
Pgp = p-glycoprotein
PI = protease inhibitor
PIDS = Pediatric Infectious Diseases Society
PK = pharmacokinetic
PMTCT = prevention of mother-to-child transmission
PPI = proton-pump inhibitor
PR = protease
PUFA = polyunsaturated fatty acid

RAL = raltegravir
RBV = ribavirin
RPG = random plasma glucose
RPV = rilpivirine
RT = reverse transcriptase
RTV = ritonavir

SJS = Stevens-Johnson syndrome
SQ = subcutaneous
SQV = saquinavir
STI = structured treatment interruptions

T-20 = enfuvirtide
TB = tuberculosis
TC = total cholesterol
TDF = tenofovir disoproxil fumarate
TDM = therapeutic drug monitoring
TEN = toxic epidermal necrolysis
TG = triglyceride
THAM = tris–hydroxymethyl-aminomethane
TMP-SMX = trimethoprim sulfamethoxazole
TPV = tipranavir
TPV/r = tipranavir/ritonavir

UA = urinalysis
UGT1A1 = uridine diphosphate
                    glucoronosyltransferase
ULN = upper limit of normal
USPHS = U.S. Public Health Service

WHO = World Health Organization

ZDV = zidovudine