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National Eye Institute Intramural Research Day--September 7, 2001

3rd Annual NEI Intramural Research Day
September 7, 2001
9:00 a.m. - 1:00 p.m.
The Cloister

Online Photo Album
Poster Presentations

Karl Csaky Paul Sieving Bruce Cumming Chi-Chao Chan Peggy Zelenka


Program

8:00 - 9:00 Continental Breakfast
9:00 - 9:05 Welcome
Karl Csaky, M.D., Ph.D.
Chairperson, 3rd Annual NEI Intramural Research Day
9:05 - 9:20 Introduction
Paul Sieving, M.D.
Director, NEI
9:20 - 9:50 Depth Perception in the Visual Cortex
Bruce Cumming, M.D., Ph.D.
Disparity Section Chief, NEI Laboratory of Sensorimotor Research
9:50 - 10:20 Newer Methodologies in Immunohistochemistry and Diagnosis
Chi-Chao Chan, M.D.
Immunopathology Section Head, NEI Laboratory of Immunology
10:20 - 10:50 CDK5 Regulates Adhesion and Migration in the Lens and Cornea
Peggy Zelenka, Ph.D.
Cell Differentiation Section Head, NEI Laboratory of Molecular and Developmental Biology
10:50 - 11:30 Coffee Break
11:30 - 1:00 Poster Session

Online Photo Album

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Poster Presentations

Expression pattern of rat MYOC/TIGR Gene at mRNA levels in different eye tissues with experimentally-induced neuronal degeneration
Farid Ahmed and Stanislav I. Tomarev
Laboratory of Molecular and Developmental Biology

Peripheral Induction of Immunologic Tolerance and Protection from Ocular Autoimmunity by Adoptive Transfer of Lymphoid Cells Expressing Endogenous IRBP
Dody Avichezer1, M.C. Kennedy1, Igal Gery1, Chi-Chao Chan1, Eric F. Wawrousek2, G.M. Lewis1, and Rachel R. Caspi1
1Laboratory of Immunology, 2Transgenic Animal and Genome Manipulation

The Recruitment of Inflammatory Cells into Vascular Endothelial Growth Factor (VEGF) Induced Choroidal Neovascularization (CNV) in the Rat
Judit Baffi, Gordon Byrnes, Rachel Salit, Scott W. Cousins, Karl Csaky
Laboratory of Immunology

The Role of IL-18 in Modulation of Experimental Autoimmune Uveitis (EAU)
Lee M. Bagenstose1, Jennifer Wahlsten1, Phyllis Silver1, Chi -Chao Chan1, David Banach2, Barbara Wiggert3, and Rachel R. Caspi1
1Laboratory of Immunology, 2BASF Bioresearch Corp., Worcester, MA, and 3Laboratory of Retinal Cell and Molecular Biology

Antigen induced uveitis mediated by Th1 or Th2 cells
Jun Chen, M.F. Zhang, G. Byrnes, L.M. Hung, Barbara P. Vistica, S.J. Kim, Eric F. Wawrousek, Chi-Chao Chan, and Igal Gery
Laboratory of Immunology

The role of estrogen in TGF-beta induced lens epithelial-mesenchymal transition
Zhengguang Chen, Melinda Chu, Ophelia Venturelli, Qui-Fang Cheng, and Deborah Carper
Laboratory of Mechanisms of Ocular Disease

Identification of cleaved intermediates of betaB2-crystallin
Christine Colvis and Donita Garland
Laboratory of Mechanisms of Ocular Diseases

Results of the National Eye Institute-Visual Function Questionnaire-25 (NEI-VFQ-25) in Patients with Diabetic Retinopathy
Michael Cusick, Emily Y. Chew, John Paul SanGiovanni, K.H. Dabas, Karl Csaky, Frederick L. Ferris
Division of Epidemiology and Clinical Research

Effects of Dexamethasone and Cyclosporin A on the Production of Cytokines by Human Corneal Epithelial Cells and Fibroblasts
Ali Djalilian, Chandra Nagineni, Janine Smith, Robert Nussenblatt, John Hooks
Laboratory of Immunology

Role of CDK5 in Cornea Epithelial Cell Adhesion and Migration
Chun Y. Gao, Sewite Negash, Dolena Ledee, and Peggy S. Zelenka
Laboratory of Molecular and Developmental Biology

Proteomics of the Normal Human Lens
Donita Garland, Karena Werth, and Christine Colvis
Laboratory of Mechanisms of Ocular Diseases

RPE65 Is Highly Uveitogenic in Rats
D.I. Ham1, Susan Gentleman2, Chi-Chao Chan1, T. Michael Redmond2, and Igal Gery1
1Laboratory of Immunology, 2Laboratory of Retinal Cell and Molecular Biology

Gelsolin, the major cytoplasmic corneal protein in zebrafish is expressed early in development
Jyotshna Kanungo and Joram Piatigorsky
Laboratory of Molecular and Developmental Biology

Humanized anti-TAC Antibody Inhibits Both IL-12-Dependent and -Independent Production of IFN-gamma from Human Peripheral Blood Mononuclear Cells
John F. McDyer, Zhuqing Li, Susan John, Xiang Yu, Chang-You Wu, and Jack A. Ragheb
Laboratory of Immunology

A Humanized Model of Experimental Autoimmune Uveitis in HLA Transgenic Mice
G. Pennesi1, S.H. Sun1, M. Mattapallil1, C.S. David2, P.A. Hargrave3, H. McDowell3, Barbara Wiggert4, Chi-Chao Chan1, and Rachel R. Caspi1
1Laboratory of Immunology, 2Mayo Clinic, Rochester, MN, 3 University of Florida and 4Laboratory of Retinal Cell and Molecular Biology

Analysis of NG2 as a marker for retinal pericytes in mice
Glorivee Pagan-Mercado1, Fatimah I. Hickman1, Robert N. Fariss2 and Jen-Yue Tsai 1
1 Laboratory of Ocular Therapeutics, and 2 Biological Imaging core Facility

Infantile cataract in the collaborative perinatal project: Prevalence and Risk Factors
Emily Y. Chew, John Paul SanGiovanni, M. Klebanoff, Nancy A. Remaley, George Reed, T. Sugimoto, J.B. Bateman
Division of Epidemiology and Clinical Research

A new PC-based method of measuring visual acuity in clinical trials: The EVA-ETDRS System
John Paul SanGiovanni, Frederick L. Ferris III, Roy W. Beck, P.S. Moke, C.A. Johnson, A. Turpin, E.E. Birch, R. Kraker, and Terry Cox
Division of Epidemiology and Clinical Research

Binding of Sequence-Specific Proteins to the AU-rich 3'UTR of the Mouse IL-2 mRNA
Yuko Seko and Jack A. Ragheb
Laboratory of Immunology

Immune-Mediated Ocular Inflammation: Detection of Cytokines by Microdissection
De Fen Shen1, S.J. Kim1, Mei-Fen Zhang1, Eric F. Wawrousek2, Igal Gery1, and Chi-Chao Chan1
1Laboratory of Immunology and 2Laboratory of Molecular and Developmental Biology

Differential Roles for IL-12 and TNF-alpha in Pathogenesis of Experimental Autoimmune Uveitis in IFN-gamma Deficient and Wild Type Mice
Phyllis B. Silver1, Rajeev K. Agarwal1, Chi-Chao Chan1, Barbara Wiggert2, and Rachel R. Caspi1
1Laboratory of Immunology and 2Laboratory of Retinal Cell and Molecular Biology

Role of "Nonlethal" Blebbing in Stress Response of Human Retinal Pigment Epithelial Cells (ARPE-19). Relevance to Age Related Macular Degeneration (AMD)
Natalia Strunnikova, Connie Zhang, and Karl Csaky
Laboratory of Immunology

Pertussis Toxin Prevents Experimental Autoimmune Uveitis Induced by Adoptive Transfer of Uveitogenic T Cells
Shao Bo Su, Phyllis B. Silver, Mei-Fen Zhang, Chi-Chao Chan, and Rachel R. Caspi
Laboratory of Immunology

Orientation-specific role of an inter-genic enhancer in the divergently transcribed mouse alpha-B crystallin and MKBP/hspB2 genes
Shivalingappa K. Swamynathan and Joram Piatigorsky
Laboratory of Molecular and Developmental Biology

Characterization of GFP labeling of retinal vasculature in SMAA-GFP mice
Jen-Yue Tsai.1, Robert N. Fariss2, Eric F. Wawrousek3, Glorivee Pagan-Mercado 1, and Fatimah I. Hickman1
1Laboratory of Ocular Therapeutics, 2Biological Imaging Core Facility, and 3Transgenic Facility

Late Onset Anterior-Segment Manifestations of Infantile Nephropathic Cystinosis
Ekaterini Tsilou, B.I. Rubin, George F. Reed, F. Iwata, W. Gahl, and Muriel I. Kaiser-Kupfer
Ophthalmic Genetics and Visual Function Branch

Detection of Toxoplasma Gondii DNA in Primary Intraocular Lymphoma
Nadine Tuaillon, DeFen Shen, C.P. Herbort, Ronald R. Buggage, Charles E. Egwuagu, and Chi-Chao Chan
Laboratory of Immunology

Shedding New Light on the Pathogenesis of Lens-Associated Uveitis
Barbara P. Vistica, Mei-Fen Zhang, L. Hung, S.J. Kim, Eric F. Wawrousek, and Igal Gery
Laboratory of Immunology

Methimazole Inhibits Experimental Autoimmune Uveoretinitis (EAU) by Inhibiting Antigen Priming
Peng Wang, S.H. Sun, Phyllis B. Silver, Chi-Chao Chan, Barbara Wiggert, Rajeev K. Agarwal, and Rachel R. Caspi
Laboratory of Immunology

Suppressors of Cytokine Signaling (SOCS) Proteins Are Constitutively and Differentially Expressed in Th1 and Th2 Cells: Implications for Th Cell Lineage Commitment and Maintenance
Cheng-Rong Yu, Mei-Fen Zhang, Rashid M. Mahdi, Igal Gery, and Charles E. Egwuagu
Laboratory of Immunology

Involvement of apoptosis-inducing factor and no caspase activation during cell death in human retinal pigmented epithelium
Congxiao Zhang, Judit Baffi, and Karl Csaky
Laboratory of Immunology

Committee Members

Karl Csaky (Chair)
Rajeev K. Agarwal
Canal Brown
Deborah Carper
Chi-Chao Chan
Susan Mellow
Phyllis Silver



Department of Health and Human Services NIH, the National Institutes of Health USA.gov