News and Events

Auditory and Visual Research in 2001

NIDCD/NEI Symposium
Natcher Building
Friday, December 14, 2001
12:00 noon to 5 pm

12:00-12:05
Welcome
Robert J. Wenthold, Ph.D.
Scientific Director, NIDCD

12:05-12:15 PM
Opening Remarks
James F. Battey, Jr., M.D., Ph.D.
Director, NIDCD

Main Menu

• Structure and Development of Receptor Systems
• Posters and Demonstrations
• Clinical Studies and Translational Research
• Acknowledgements
• Posters
• Online Photo Album

Structure and Development of Receptor Systems

Chair
Doris Wu, Ph.D.
Acting Chief, Section of Sensory Cell Regeneration & Development
NIDCD

12:15-12:45 PM
Joram Piatigorsky, Ph.D.
Chief, Laboratory of Molecular and Developmental Biology, NEI
"Developmental pathways in lens and cornea"

12:45-1:15 PM
Matthew Kelley, Ph.D.
Acting Chief, Section on Developmental Neuroscience, NIDCD
"Determination of cell fate and cell patterning in the mammalian cochlea"

1:15-1:45 PM
Bechara Kachar, M.D.
Chief, Section on Structural Cell Biology, NIDCD
"Essential cytoskeletal components in sensory stereocilia development and function"

Posters and Demonstrations

1:45-3:20 PM
Snacks and Beverages

Clinical Studies and Translational Research

Chair
Janine Smith, M.D.
Deputy Clinical Director
NEI

3:20-3:50 PM
Emily Chew, M.D.
Deputy Director, Division of Epidemiology and Clinical Research, NEI
"Causes, prevention, and treatment of vision disorders"

3:50-4:20
Graeme Wistow, Ph.D.
Chief, Section on Molecular Structure and Function, NEI
"NEIBANK: Bioinformatics and Functional Genomics"

4:20-4:50 PM
Thomas B. Friedman, Ph.D.
Chief, Laboratory of Molecular Genetics, NIDCD
"Molecular genetics of hereditary deafness"

4:50-5:00 PM
Closing Remarks
Paul Sieving, M.D., Ph.D.
Director, NEI

Acknowledgements

Organizers:

James Battey, Paul Sieving
Robert Wenthold, Robert Nussenblatt, Robert Wurtz
David Robinson, Deborah Carper

Symposium Committee:

John Paul SanGiovanni
Cindy Jaworski
Connie Zhang

Rajeev Agarwal
Kym Collins-Lee
Sewite Negash

Peggy Zelenka
Leigh Walters
Belinda Davis

Posters

MOLECULAR GENETICS:

1. Refining the genetic interval for an autosomal dominant hearing impairment locus, DFNA27, on chromosome 4q12-13. LM Peters, RA Fridell, EA Boger, AC Madeo, T San Agustin, MJ Brownstein, TB Friedman, RJ Morell

2. The H723R mutation of PDS: Evidence for a founder allele that is a common cause of recessive deafness in Korea. H-J Park, S Abe, K Tukamoto, X-Z Liu, R Erdentungalag, J Radnaabazar, A Pandya, WE Nance, S Usami, AJ Griffith

3. Ascertainment of familial cases of auditory tone deafness. J Larsen, K Laws, S Woodward, D Drayna

4. Natural history of Usher syndrome and comparison of severity of Usher type I and II. E Tsilou, BI Rubin, RC Caruso, G Reed, JF Hejtmancik, F Iwata, J Redman, MI Kaiser-Kupfer

5. Cloning of a novel cadherin, Cdh23, and identification of mutations in waltzer (v) and Usher syndrome type 1D. F Di Palma, H Bolz, R Holme, E Bryda, I Belyantseva, B Kachar, K Steel, C Kubisch, K Noben-Trauth

6. Mutations in CDH23 cause nonsyndromic deafness (DFNB12) and Usher syndrome type 1D (USH1D). JM Bork, S Riazuddin, Z Ahmed, S Riazuddin, ER Wilcox, TB Friedman, RJ Morell

7. Genetic analysis of bitter taste deficits in humans. U-K Kim, B Otterud, H Coon, M Leppert, D Drayna

8. Linkage studies of stuttering in consanguineous families. N Riaz, J Ahmad, S Riazuddin, D Drayna

GENE STRUCTURE/EXPRESSION:

9. A family of 12 human genes containing oxysterol-binding domains. CJ Jaworski, IR Rodriguez

10. Expression and promoter activation of the RPE65 gene in vivo and in vitro. A Boulanger, SY Liu, S Yu, TM Redmond

11. Genomic organization and alternative splicing of a new olfactomedin-related gene highly expressed in the tissues of the rat eye angle and retina. R Trivedi, M Torrado, R Zinovieva, F Ahmed, SI Tomarev

12. Molecular profiling of squamous cell carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis and the NF-kappaB signal pathway. Z Chen, G Dong, E Loukinova, L Gangi, TI Chanturita, ET Liu, C Van Waes

13. Issues and progress in the production of the NEIbank human eyechip. KM Peterson, EA Donarum, G Wistow

14. Construction and analysis of a taste receptor-cell enriched cDNA library. N Lopez, E Sainz, J Battey, S Sullivan

15. Changes in gene expression pattern in the retina after experimentally-induced neuronal degeneration. F Ahmed, KM Brown, DA Stephan, J Morrison, E Johnson, SI Tomarev

16. Identification of two cDNAs, ID1 and FABP, up-regulated upon lens cell differentiation. DR Ledee, PS Zelenka

17. Characterization of human aldose reductase expression in retina of SMAA-HAR mice. FI Hickman, G Pagan-Mercado, T Yamamoto, RN Fariss, E Wawrousek, J Tsai

18. Characterization of vascular GFP expression in SMAA-GFP mice. J Tsai, RN Fariss, E Wawrousek, G Pagan-Mercado, FI Hickman, T Yamamoto

PROTEINS-STRUCTURE/FUNCTION:

19. Evidence of spatially distinct cation and calcimimetic compound (NPS 568) recognition sites in transmembrane regions of the human Ca2+ receptor. K Ray, JK Northup

20. G-beta-gamma affinity for bovine rhodopsin is determined by the carboxyl terminal sequences of the gamma subunit. X Jian, WA Clark, J Kowalak, SP Markey, WF Simonds, JK Northup

21. Effect of thiolation of alpha-crystallin on the chaperoning of denatured lactalbumin and insulin. R Neal, K Wawrousek, JS Zigler, Jr

22. New eye proteins from data mining. MK Wyatt, GJ Wistow

23. Characterization of PEDF-collagen interactions. C Meyer, R Farris, SP Becerra

24. Identification of lens proteins interacting with MIP/Aquaporin 0. J Fan, AK Donovan, DR Ledee, PS Zelenka, AB Chepelinsky

25. Optimedin, a new olfactomedin-related protein interacting with myocilin. SI Tomarev, M Torrado, R Trivedi, I Karavanova

MODEL SYSTEMS:

26. Knockout of small heat shock protein genes alphaA - and alphaB-crystallin: Lens and muscle phenotypes. E Wawrousek, JP Brady, ER Tamm, DL Garland, DE Green, J Horwitz, WG Robison

27. The NEI central transgenic facility: A core facility supporting vision research. C Haugen, S Lee, E Wawrousek

28. Heat shock proteins and lens pathology. C Colvis, D Garland

29. Protein prenylation, statins, and cataract. QF Cheng, JS Zigler, Jr

30. Gene expression of matrix metalloproteinases (MMPs) and tissue inhibitory metalloproteinases (TIMPs) in an oxidative stress model of cataract. M John, A Spector, D Carper

31. Role of "nonlethal" blebbing in protection of human retinal pigment epithelial cells (ARPE-19) from oxidative stress: Relevance to age related macular degeneration (AMD). NS Strunnikova, C Zhang, K Csaky

32. Regression of SV40 T antigen-induced ocular tumor is mediated by the tumor suppressors IRF-1 and ICSBP. CE Egwuagu, W Li, C-R Yu, SJ Ebong, T Nakamura, C-C Chan, AB Chepelinsky

33. The protective role of estrogen in the ocular lens. Z Chen, O Venturelli, S Subramanian, D Carper

DEVELOPMENT:

34. Proteomics: application to lens development. D Garland, D Wilson, J Meyer, C Colvis

35. Developmental loss of alphaB-crystallin promoter activity of the blind mole rat in the lens and not in the heart and muscle. RB Hough, A Avivi, J Davis, J Alma, E Nevo, J Piatigorsky

36. Inhibition of protein kinase C induces supernumerary inner hair cells in the developing mammalian cochlea. A Dabdoub, MJ Donohue, J Jones, PJ Lanford, MW Kelley

37. Cellular patterning in the organ of Corti is dependent on interactions between epithelial and mesenschymal cells. M Montcouquiol, MW Kelley

38. Expression of Splat1 and 3 in the development of the mouse inner ear. O Howard, DK Wu

39. Basic fibroblast growth factor and bone morphogenetic protein 2 act jointly in the formation of the semicircular canals during chicken inner ear development. W Chang, DK Wu

40. Investigating targeted tissues of BMP2 and 4 in the developing chicken inner ear using anti-phosphorylated smad antibody. W Chang, P ten Dijke, DK Wu

CELL BIOLOGY:

41. Water permeability of cochlear outer hair cells: Characterization and relationship to electromotility. I Belyantseva, G Frolenkov

42. A role for cdk5 in corneal epithelial cell adhesion and migration CY Gao, S Negash, PS Zelenka

43. High-resolution structure of hair-cell tip links. B Kachar

44. Cell death in human retinal pigmented epithelium (hRPE) involves apoptosis-inducing-factor and no caspase activation. C Zhang, J Baffi, K Csaky

45. Expression of stearoyl-coA desaturase in human retinal pigment epithelial cells: Regulation by retinoic acid and transforming growth factor-beta. W Samuel, RK Kutty, CN Nagineni, JJ Hooks, B Wiggert

46. Expression of beta-carotene15, 15' dioxygenase in RPE and retina comparison with RPE65. S Yu, R Bhatti, A Boulanger, RN Fariss, S Gentleman, M Redmond

IMMUNOLOGY:

47. Developing peptide vaccines that mimic lipooligosaccharide from nontypeable Haemophil Influenzae using a phage display library. Y Hou, X-X Gu

48. Intranasal immunization with a lipooligosaccharide-based conjugate vaccine from nontypeable Haemophilus influenzae enhances bacterial clearance from mouse nasopharynx. T Hirano, Y Hou, X-X Gu

49. Retroviral gene therapy for experimental autoimmune uveitis (EAU): Duration and mechanism of tolerance. RK Agarwal, DW Scott, C-C Chan, RR Caspi

50. Immunologically privileged expression of a sequestered retinal antigen results in tolerance. D Avichezer, GI Liou, C-C Chan, GM Lewis, MA Crawford, B Wiggert, RR Caspi

51. Inflammatory mediators in uveitis: Differential induction of cytokines and chemokines in Th1- vs. Th2-mediated ocular inflammation. E Foxman, M Zhang, S Hurst, T Muchamuel, D Shen, E Wawrousek, C-C Chan, I Gery

52. Cytomegalovirus infection induces differential expression and secretion of MCP-1, MCP-3 and IL-8 by human retinal pigment epithelial cells. Y Momma, CN Nagineni, MS Chin, K Srinivasan, B Detrick, JJ Hooks

53. Differential regulation of suppressors of cytokine signaling (SOCS) proteins in Th1 and Th2 lymphocytes: Implications for the cell differentiation and lineage commitment. C-R Yu, M Zhang, RM Mahdi, I Gery, CE Egwuagu

54. Chemokine receptor expression in ocular cells during herpes simplex virus 1 (HSV-1) infection. K Srinivasan, JJ Hooks

AUDITORY AND VISUAL PROCESSING/BIOSTATISTICS/MODELING:

55. A large-scale computational model relating neuronal activity for central auditory processing to functional brain imaging data. F Husain, A Ulloa, A Braun, B Horwitz

56. Diagnosis of optic chiasm decussation anomalies with steady-state flash evoked potentials. RC Caruso, LM Ayres, RW Hertle, MI Kaiser-Kupfer

57. Combining correlations from both eyes. GF Reed

CLINICAL:

58. Dry eye in patients with karyotypically normal spontaneous premature ovarian failure. JA Smith, GF Reed, SA Grieshaber, L Goodman, VH Vanderhoof, LN Nelson

59. Molecular studies of primary intraocular lymphoma. DF Shen, N Tuaillon, RR Buggage, RB Nussenblatt, C-C Chan

60. Muscle tendon enthesis in patients with congenital nystagmus. DA Galita, RW Hertle, MA Crawford, M Maybodi, C-C Chan

61. Autoantibodies to transcription coactivators p75/p52 (LEDGF) found in patients with retinopathy of unknown origin. MS Chin, R Caruso, B Detrick, JJ Hooks

62. Qualitative research activities in the Office of Communication, Health Education and Public Liaison. K Silver, R Janiszewski

63. A randomized placebo-controlled clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. The Age-Related Eye Disease Study Research Group

64. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss. The Age-Related Eye Disease Study Research Group

65. A new PC-based method of measuring visual acuity in clinical trials: The EVA-ETDRS system. JP SanGiovanni, FL Ferris III, RW Beck, PS Moke, CA Johnson, A Turpin, EE Birch, R Kraker, TA Cox, WR O'Donnell, G Foster, R Mercer TORY

66. Steady state stimuli in clinical electrophysiology of vision. L Ayres, P Lopes, RC Caruso

67. NEIBank/Eyesite web site and databases. G Wistow, D Smith, P Gesuwan, J Gao

68. Bayes' Theorem: A pictorial tutorial. TA Cox