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Home » Research at NEI » Unit on Retinal Neurophysiology

Unit on Retinal Neurophysiology

Wei Li, Ph.D.
Dr. Wei Li

This unit is led by Wei Li, Ph.D.

Porter Neuroscience Research Center
Building 35, Room 2A-108
35 Convent Drive, MSC 3739
Bethesda, MD 20892-3739
Tel: (301) 496-6669
Fax: (301) 480-5895

Research Interests

Our unit studies the structure and function of retinal synapses and circuits. Although we know the basic structure and major cell types of the retina, it remains much of a "black box" in terms of the connections and functions of these neurons. Our long-term research goal is to understand how the neuronal circuits are wired in this "black box" under normal conditions and how the circuits are altered during pathological processes. Both pieces of information will be crucial for the design of biological and/or prosthetic interventions aiming to restore vision in many types of blindness caused by retinal degenerative diseases. We'll exploit a combination of anatomical and physiological approaches to study synaptic connectivity using in vitro slice and flat-mount preparations of the ground squirrel retina. This is an excellent model system to study the cone vision, as ground squirrel is one of the rare mammals whose retina is cone-dominated and resembles the fovea of human retina.


Name Title Telephone E-mail
Wei Li, Ph.D. Unit Chief (301) 496-6669
Shan Chen, M.D., Ph.D. Biologist (301) 451-1937
Jodie Pope, Ph.D. Postdoctoral Fellow (301) 402-5459
Fengyu Qiao, Ph.D. Scientist (301) 402-2595
Li Jia, Ph.D. Research Fellow (301) 451-4526

Selected Publications

Department of Health and Human Services NIH, the National Institutes of Health