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Biological Imaging Core Facility

  • bov RPE VSVG GFP transf Thurs (15) 9AM
    Viewed with a confocal microscope, the retinal pigment epithelial cells (RPE) from a bovine (cow) eye display tight packing reminiscent of a honeycomb. Actin, a cytoskeletal protein found in the junctions between neighboring cells is labeled with a red fluorescent probe. Some RPE cells in this image have been transfected with a virus, causing them to express high levels of green fluorescent protein (GFP). GFP, originally isolated from the jellyfish Aequorea victoria, has become a valuable tool for scientists studying protein expression in living cells and animals. (Image courtesy of Dr. Enrique Rodriguez Boulan, Cornell University and Dr. Robert Fariss, NEI Biological Imaging Core.)

Core Chief: Robert N. Fariss, Ph.D.
Building 6, room 202
6 Center Drive, National Institutes of Health
Bethesda, Maryland 20892-0606
Phone (301) 496-2829
FAX (301) 480-7939


High resolution fluorescence imaging of ocular tissues presents unique opportunities as well as technical challenges for scientists attempting to visualize pathological changes in the cornea, lens, retina or retinal pigment epithelium. Exploiting the transparency of the vertebrate eye and innovations in ocular imaging, vision researchers and ophthalmologist have gained unprecedented insight into a wide array of ocular processes.

Mission Statement

The National Eye Institute's Biological Imaging Core provides NEI scientists with a wide range of high resolution imaging and analysis applications including confocal microscopy, multi-photon imaging, total internal reflectance fluorescence (TIRF) imaging, laser capture microdissection, in vivo and in vitro imaging. The primary objective of the Biological Imaging Core is to pair state-of-the-art instrumentation with novel imaging approaches to provide vision scientists new avenues for studying ocular disease processes.

Facilities and Equipment



Name Title E-mail
Robert N. Fariss, Ph.D. Chief
Maria M. Campos, M.D. Staff Scientist
Chun Y. Gao, M.D., Ph.D. Staff Scientist

Last Reviewed: March 2011

Department of Health and Human Services NIH, the National Institutes of Health