Human Genome Project Information Genomic Science Program DOE Microbial Genomics home About the HGP Ethical / Legal Issues Medicine Education Gene Gateway Research Archive Goals History Timeline Benefits ELSI Genetics 101 FAQs U.S. Human Genome Project 5-Year Research Goals 1998-2003 Basic Information  FAQs  Glossary  Acronyms  Links  Genetics 101  Publications  Media Guide About the Project  What is it?  Goals  Landmark Papers  Sequence Databases  Timeline  History  Ethical Issues  Benefits  Genetics 101  FAQs Medicine & the New Genetics  Home  Gene Testing  Gene Therapy  Pharmacogenomics  Disease Information  Genetic Counseling Ethical, Legal, Social Issues  Home  Privacy Legislation  Gene Testing  Gene Therapy  Patenting  Forensics  Genetically Modified Food  Behavioral Genetics  Minorities, Race, Genetics  Human Migration Education  Teachers  Students  Careers  Webcasts  Images  Videos  Chromosome Poster  Presentations  Genetics 101  Genética Websites en Español Research  Home  Sequence Databases  Landmark Papers  Insights Publications  Chromosome Poster  Primer Molecular Genetics  List of All Publications   Search This Site    Contact Us  Privacy Statement  Site Stats and Credits  Site Map Five-Year Research Goals of the U.S. Human Genome Project October 1, 1998, to September 30, 2003 Human DNA Sequence Finish the complete human genome sequence by the end of 2003. Finish one-third of the human DNA sequence by the end of 2001. Achieve coverage of at least 90% of the genome in a working draft based on mapped clones by the end of 2001. Make the sequence totally and freely accessible. Sequencing Technology Continue to increase the throughput and reduce the cost of current sequencing technology. Support research on novel technologies that can lead to significant improvements in sequencing technology. Develop effective methods for the advanced development and introduction of new sequencing technologies into the sequencing process. Human Genome Sequence Variation Develop technologies for rapid, large-scale identification and/or scoring of single nucleotide polymorphisms and other DNA sequence variants. Identify common variants in the coding regions of the majority of identified genes during this five-year period. Create a SNP map of at least 100,000 markers. Develop the intellectual foundations for studies of sequence variation. Create public resources of DNA samples and cell lines. Functional Genomics Technology Generate sets of full-length cDNA clones and sequences that represent human genes and model organisms. Support research on methods for studying functions of nonprotein-coding sequences. Develop technology for comprehensive analysis of gene expression. Improve methods for genome-wide mutagenesis. Develop technology for large-scale protein analyses. Comparative Genomics Complete the sequence of the roundworm C. elegans genome by 1998. Complete the sequence of the fruitfly Drosophila genome by 2002. Develop an integrated physical and genetic map for the mouse, generate additional mouse cDNA resources, and complete the sequence of the mouse genome by 2008. Identify other useful model organisms and support appropriate genomic studies. Ethical, Legal, and Social Issues Examine issues surrounding the completion of the human DNA sequence and the study of human genetic variation. Examine issues raised by the integration of genetic technologies and information into health care and public health activities. Examine issues raised by the integration of knowledge about genomics and gene-environment interactions in non-clinical settings. Explore how new genetic knowledge may interact with a variety of philosophical, theological, and ethical perspectives. Explore how racial, ethnic, and socioeconomic factors affect the use, understanding, and interpretation of genetic information; the use of genetic services; and the development of policy. Bioinformatics and Computational Biology Improve content and utility of databases. Develop better tools for data generation, capture, and annotation. Develop and improve tools and databases for comprehensive functional studies. Develop and improve tools for representing and analyzing sequence similarity and variation. Create mechanisms to support effective approaches for producing robust, exportable software that can be widely shared. Training and Manpower Nurture the training of scientists skilled in genomics research. Encourage the establishment of academic career paths for genomic scientists. Increase the number of scholars who are knowledgeable in both genomic and genetic sciences and in ethics, law, or the social sciences.   5-Year Plan Home Last modified: Friday, September 03, 2004 Home * Contacts * Disclaimer Document Use and Credits Publications and webpages on this site were created by the U.S. Department of Energy Genome Program's Biological and Environmental Research Information System (BERIS). Permission to use these documents is not needed, but please credit the U.S. Department of Energy Genome Programs and provide the website http://genomics.energy.gov. All other materials were provided by third parties and not created by the U.S. Department of Energy. You must contact the person listed in the citation before using those documents. Base URL: www.ornl.gov/hgmis Site sponsored by the U.S. Department of Energy Office of Science, Office of Biological and Environmental Research, Human Genome Program