Fact Sheet
Comparative Toxicogenomics Database (CTD)™
The Comparative Toxicogenomics Database (CTD) elucidates molecular mechanisms by which environmental chemicals affect human disease. CTD is a data file on the National Library of Medicine's (NLM) Toxicology Data Network (TOXNET®). It contains manually curated data describing cross-species chemical–gene/protein interactions and chemical– and gene–disease relationships. The results provide insight into the molecular mechanisms underlying variable susceptibility and environmentally influenced diseases. These data will also provide insights into complex chemical–gene and protein interaction networks.
CTD is developed at North Carolina State University (NCSU) http://www.ncsu.edu. The development team is located at NCSU and the Mount Desert Island Biological Laboratory (MDIBL) http://www.mdibl.org/. CTD receives funding from the National Institute of Environmental Health Sciences (NIEHS) http://www.niehs.nih.gov/ and the National Library of Medicine (NLM) http://www.nlm.nih.gov/ by the R01 ES014065 "Comparative Toxicogenomics Database" grant, as well as through an administrative supplement (R01 ES014065-04S1) and another R01 (R01 ES019604), "Generation of a centralized and integrated resource for exposure data," from the NIEHS.
Web Access/Searching
CTD is accessible, free of charge, via TOXNET at: http://toxnet.nlm.nih.gov
In TOXNET, users can search chemicals (by name or CAS registry number) and see the related genes and diseases. Users can then be taken via the TOXNET’s CTD results to the complete CTD site for further details.
Once in the complete CTD site via TOXNET, users can perform several types of searches, for example:
- Browse relationships among chemicals, and obtain detailed information about them, including structure, toxicology data and related genes, diseases, pathways and references. See: Chemicals
- Browse relationships among diseases, and obtain detailed information about them, including related chemicals, genes, pathways and references. See: Diseases
- Browse search for genes from diverse vertebrates and invertebrates by symbol, synonym, accession ID, organism taxon, chemical, interaction type, disease or Gene Ontology annotation. See: Genes
- Search for cross-species chemical–gene and protein interactions curated from the published literature. Interactions may be retrieved by chemical, interaction type, gene, organism or Gene Ontology annotation. See: Chemical–Gene Interactions
- Search for references by gene, organism taxon, chemical, chemical–gene interaction type, disease, citation information or accession ID. See: References
Further examples of searches that can be conducted once users are in the complete CTD site via TOXNET include:
- Which human diseases are associated with a gene/protein? (Sample query)
- Which human diseases are associated with a chemical? (Sample query)
- Which genes/proteins interact with a chemical? (Sample query)
- Which chemicals interact with a gene/protein? (Sample query)
- Which references report a chemical–gene/protein interaction? (Sample query)
- Which cellular functions (GO terms) are affected by a chemical? (Sample query)
Users can also easily conduct their CTD search strategy against other databases, e.g., Hazardous Substances Data Bank®, TOXLINE®, and ChemIDplus®.
Further Information
For detailed information about CTD or TOXNET, contact:
CTD Representative
Specialized Information Services
National Library of Medicine
Two Democracy Plaza, Suite 510
6707 Democracy Boulevard, MSC 5467
Bethesda, MD 20892-5467
Telephone (30l) 496-1131
FAX: (301) 480-3537
e-mail: tehip@teh.nlm.nih.gov
URL: http://sis.nlm.nih.gov
For comments on CTD content, contact:
Comparative Toxicogenomics Database
Mount Desert Island Biological Laboratory
P.O. Box 35, Old Bar Harbor Road
Salisbury Cove, ME 04672, USA
Phone: 207-288-9880 ext. 283
e-mail: Go to http://ctd.mdibl.org/help/contact.go
URL: http://www.mdibl.org/ctd.php
For information on NLM services, contact:
National Library of Medicine
Customer Service
8600 Rockville Pike
Bethesda, MD 20894
Telephone: 1-888-FINDNLM (1-888-346-3656) or (301) 594-5983
e-mail: custserv@nlm.nih.gov
A complete list of NLM Fact Sheets is available at:
(alphabetical list) http://www.nlm.nih.gov/pubs/factsheets/factsheets.html
(subject list): http://www.nlm.nih.gov/pubs/factsheets/factsubj.html
Or write to:
FACT SHEETS
Office of Communications and Public Liaison
National Library of Medicine
8600 Rockville Pike
Bethesda, Maryland 20894
Phone: (301) 496-6308
Fax: (301) 496-4450
email: publicinfo@nlm.nih.gov
