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	MDMA/Ecstasy Research: Advances, Challenges, Future Directions A Scientific Conference

This Conference was held at the Natcher Auditorium on the NIH Campus, July 19-20, 2001.

Thursday, July 19, 2001
Agenda
8:30 a.m. - 8:45 a.m.	Welcome and Meeting Overview
	Glen R. Hanson, D.D.S., Ph.D. Director Division of Neuroscience and Behavioral Research National Institute on Drug Abuse
	Alan I. Leshner, Ph.D. Director National Institute on Drug Abuse
8:45 a.m. - 9:00 a.m.	Keynote Addresses
	Ruth L. Kirschstein, M.D. Acting Director National Institutes of Health
	The Honorable Tommy G. Thompson Secretary of Health and Human Services (invited)
SESSION I: Patterns and Trends of MDMA Abuse: Implications for Prevention
9:00 a.m. - 9:15 a.m.	Patterns and Trends of MDMA Abuse: Implications for Prevention
9:00 a.m. - 9:15 a.m.	Moderator:Jacques L. Normand, Ph.D. Acting Chief Epidemiology Research Branch National Institute on Drug Abuse
9:15 a.m. - 9:35 a.m.	Public Health Perspective on MDMA
9:15 a.m. - 9:35 a.m.	James N. Hall, B.A. Executive Director Up Front Drug Information Center Miami, Florida
9:35 a.m. - 9:55 a.m.	Patterns of MDMA Use Among Men Who Have Sex With Men in Boston and New York City
9:35 a.m. - 9:55 a.m.	Patricia Case, Sc.D. Director Program in Urban Health Department of Social Medicine Harvard Medical School Boston, Massachusetts
9:55 a.m. - 10:15 a.m.	Patterns and Trends of MDMA Use and Sexual Risk Behavior in Central Ohio
9:55 a.m. - 10:15 a.m.	Robert G. Carlson, Ph.D. Professor Center for Interventions, Treatment, and Addictions Research Wright State University School of Medicine Dayton, Ohio
10:15 a.m. - 10:40 a.m.	BREAK
10:40 a.m. - 11:00 a.m.	The Diffusion of MDMA Use Among Urban Youth in Hartford, Connecticut; Implications for Drug and HIV Prevention in Club Drug Users and Their Networks
10:40 a.m. - 11:00 a.m.	Jean J. Schensul, Ph.D. Executive Director Institute for Community Research Hartford, Connecticut
11:00 a.m. - 11:30 a.m.	A Burning Candle: Challenges in Ecstasy Research
11:00 a.m. - 11:30 a.m.	Claire E. Sterk, Ph.D., Discussant Professor Department of Behavioral Sciences and Health Education Rollins School of Public Health Emory University Atlanta, Georgia
11:30 a.m. - 12 noon	Question and Answer Panel
11:30 a.m. - 12 noon	Moderator: Jacques L. Normand, Ph.D. Acting Chief Epidemiology Research Branch National Institute on Drug Abuse
12 noon - 1:15 p.m.	LUNCH (on your own)
SESSION II: Acute Effects
1:15 p.m. - 1:30 p.m.	Acute Effects
1:15 p.m. - 1:30 p.m.	Moderator: Jean Lud Cadet, M.D. Chief Molecular Neuropsychiatry Section Clinical Director Intramural Research Program National Institute on Drug Abuse
1:30 p.m. - 2:00 p.m.	Neurochemical Mediators and Neurophysiological Consequences of Acute MDMA Exposure in Rats
1:30 p.m. - 2:00 p.m.	Bryan K. Yamamoto, Ph.D. Professor of Psychiatry and Neurosciences Director Program in Basic and Clinical Neuroscience University Hospitals of Cleveland and Case Western Reserve University Cleveland, Ohio
2:00 pm. - 2:30 p.m.	The Acute Cardiovascular, Endocrine, and Pharmacokinetic Effects of MDMA in Humans
2:00 pm. - 2:30 p.m.	John Mendelson, M.D. Associate Clinical Professor of Psychiatry and Medicine Drug Dependence Research Center Langley Porter Psychiatric Institute University of California at San Francisco San Francisco, California
2:30 p.m. - 3:00 p.m.	Subjective, Reinforcing, and Discriminative Stimulus Effects of MDMA in Humans
2:30 p.m. - 3:00 p.m.	Manuel E. Tancer, M.D. Associate Professor Departments of Psychiatry and Behavioral Neurosciences, and Pharmacology Wayne State University School of Medicine Detroit, Michigan
3:00 p.m. - 3:30 p.m.	BREAK
3:30 p.m. - 4:00 p.m.	"Ecstasy" Deaths - More Than Just MDMA: An Australian Perspective
3:30 p.m. - 4:00 p.m.	Rodney J. Irvine, Ph.D. Research Fellow Department of Clinical and Experimental Pharmacology University of Adelaide Adelaide, Australia
4:00 p.m. - 4:30 p.m.	Acute Effects of MDMA: What Don't We Know?
4:00 p.m. - 4:30 p.m.	Gantt P. Galloway, Pharm.D, Discussant Chief of Pharmacological Research Haight Ashbury Free Clinics, Inc. San Francisco, California
4:30 p.m. - 5:00 p.m.	Question and Answer Panel
4:30 p.m. - 5:00 p.m.	Moderator: Jean Lud Cadet, M.D. Chief Molecular Neuropsychiatry Section Clinical Director Intramural Research Program National Institute on Drug Abuse
5:00 p.m. - 6:30 p.m.	POSTER PRESENTATIONS
Friday, July 20, 2001
SESSION III: Long-Term Toxicology
8:30 a.m. - 8:45 a.m.	Long-Term Toxicology
8:30 a.m. - 8:45 a.m.	Moderator: Steven Grant, Ph.D. Program Administrator Clinical Neurobiology Branch National Institute on Drug Abuse
8:45 a.m. - 9:15 a.m.	Overview of MDMA-induced Persistent Neurotoxicity: Preclinical Perspective
8:45 a.m. - 9:15 a.m.	Glen R. Hanson, D.D.S., Ph.D. Director Division of Neuroscience and Behavioral Research National Institute on Drug Abuse
9:15 a.m. - 9:45 a.m.	Developmental Effects of MDMA
9:15 a.m. - 9:45 a.m.	Charles V. Vorhees, Ph.D. Professor Division of Developmental Biology Children's Hospital Medical Center Cincinnati, Ohio
9:45 a.m. - 10:15 a.m.	MDMA-Induced Brain Serotonin Neurotoxicity: Preclinical Studies
9:45 a.m. - 10:15 a.m.	George A. Ricaurte, M.D., Ph.D. Associate Professor Department of Neurology Johns Hopkins University School of Medicine Baltimore, Maryland
10:15 a.m. - 10:45 a.m.	BREAK
10:45 a.m. - 11:15 a.m.	Neuroimaging Studies in Chronic Effects of MDMA/Ecstasy Use
10:45 a.m. - 11:15 a.m.	Linda Chang, M.D. Scientist and Chair Medical Department Brookhaven National Laboratory Upton, New York
11:15 a.m. - 11:45 a.m.	Discussion, and Degeneration in Brain Following Binge Stimulants: All Dopaminergics Induce Degeneration in Fasciculus Retroflexus, but MDMA Also Induces Degeneration in Oral Pontine Serotonin Terminals
11:15 a.m. - 11:45 a.m.	Gaylord D. Ellison, Ph.D., Discussant Professor of Psychology and Neuroscience University of California at Los Angeles Los Angeles, California
11:45 a.m. - 12:15 p.m.	Question and Answer Panel
11:45 a.m. - 12:15 p.m.	Moderator: Steven Grant, Ph.D. Program Administrator Clinical Neurobiology Branch National Institute on Drug Abuse
12:15 p.m. - 1:30 p.m.	LUNCH
SESSION IV: Long-Term Functional Consequences: Behavioral, Mood, Psychiatric, and Cognitive
1:30 p.m. - 1:45 p.m.	Long-Term Functional Consequences: Behavioral, Mood, Psychiatric, and Cognitive
1:30 p.m. - 1:45 p.m.	Moderator: Minda R. Lynch, Ph.D. Acting Chief Behavioral and Cognitive Science Research Branch National Institute on Drug Abuse
1:45 p.m. - 2:15 p.m.	Neuropsychopathology Associated With MDMA
1:45 p.m. - 2:15 p.m.	Andy C. Parrott, Ph.D. Professor, Department of Psychology Head of the Recreational Drugs Research Group University of East London London, United Kingdom
2:15 p.m. - 2:45 p.m.	MDMA-Induced Brain Serotonin Neurotoxicity: Clinical Studies
2:15 p.m. - 2:45 p.m.	Una D. McCann, M.D. Associate Professor Behavioral Pharmacology Research Unit Johns Hopkins School of Medicine Baltimore, Maryland
2:45 p.m. - 3:15 p.m.	Long-Term Consequences of Ecstasy Use Upon Cognition
2:45 p.m. - 3:15 p.m.	Euphrosyne Gouzoulis-Mayfrank, M.D. Associate Professor Department of Psychiatry and Psychotherapy Medical Faculty of the University of Technology Aachen, Germany
3:15 p.m. - 3:30 p.m.	BREAK
3:30 p.m. - 4:00 p.m.	Are the Psychological Problems Associated With Regular MDMA Use Reversed by Prolonged Abstinence?
3:30 p.m. - 4:00 p.m.	Michael John Morgan, Ph.D. Senior Lecturer Department of Experimental Psychology School of Biological Sciences University of Sussex, Falmer Brighton, United Kingdom
4:00 p.m. - 4:30 p.m.	Long-Term Functional Consequences of MDMA Abuse
4:00 p.m. - 4:30 p.m.	H. Valerie Curran, Ph.D., Discussant Professor of Psychopharmacology Sub-Department of Clinical Health Psychology University College London London, United Kingdom
4:30 p.m. - 4:55 p.m.	Question and Answer Panel
4:30 p.m. - 4:55 p.m.	Moderator: Minda R. Lynch, Ph.D. Acting Chief Behavioral and Cognitive Science Research Branch National Institute on Drug Abuse
4:55 p.m. - 5:00 p.m.	MDMA Research: What Next?
4:55 p.m. - 5:00 p.m.	Jerry Frankenheim, Ph.D., Conference Chair Pharmacologist and Program Official Pharmacology, Integrative and Cellular Research Branch National Institute on Drug Abuse
5:00 p.m.	ADJOURNMENT

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