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Reviewed August 2012
What is the official name of the KRT16 gene?
The official name of this gene is “keratin 16.”
KRT16 is the gene's official symbol. The KRT16 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KRT16 gene?
The KRT16 gene provides instructions for making a protein called keratin 16 or K16. Keratins are a group of tough, fibrous proteins that form the structural framework of certain cells, particularly cells that make up the skin, hair, and nails. Keratin 16 is produced in the nails, the skin on the palms of the hands and soles of the feet, and the oral mucosa that lines the inside of the mouth.
Keratin 16 partners with a similar protein, keratin 6a, to form molecules called keratin intermediate filaments. These filaments assemble into dense networks that provide strength and resilience to the skin, nails, and other tissues. Networks of keratin filaments protect these tissues from being damaged by friction and other everyday physical stresses. Keratin 16 is also among several keratins involved in wound healing.
Does the KRT16 gene share characteristics with other genes?
The KRT16 gene belongs to a family of genes called KRT (keratins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KRT16 gene related to health conditions?
Where is the KRT16 gene located?
Cytogenetic Location: 17q21.2
Molecular Location on chromosome 17: base pairs 39,766,029 to 39,769,078
The KRT16 gene is located on the long (q) arm of chromosome 17 at position 21.2.
More precisely, the KRT16 gene is located from base pair 39,766,029 to base pair 39,769,078 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KRT16?
You and your healthcare professional may find the following resources about KRT16 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KRT16 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KRT16?
acids ; amino acid ; blister ; callus ; cell ; cytokeratin ; domain ; gene ; intermediate filaments ; keratin ; keratoderma ; molecule ; motif ; mucosa ; mutation ; pachyonychia ; palmoplantar keratoderma ; protein ; resilience ; sign ; stress ; symptom ; tissue ; trauma
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.