History shows that it is difficult to predict which research projects will result in transformative results before the research is conducted and the scientific community has assimilated the findings.

A classic example of this challenge is Barbara McClintock’s pioneering cytogenetic research in maize.  In 1944 McClintock theorized that genes are transposable on and between chromosomes.  After years of observation and controlled experiments she published her first work on genetic transposition in 1948.  Because her research challenged conventional wisdom it was not accepted by the scientific community until many years later.  A decade passed before the importance of McClintock’s discovery was accepted by the scientific community.  In the early 60s, research on genetic regulation demonstrated some of the same concepts that McClintock had championed.  Molecular techniques developed in the late 60s and 70s demonstrated the molecular-genetic mechanisms of transposition discovered by McClintock.  With time, the significance and transformative nature of her research became widely accepted and her accomplishments were honored with the National Medal of Science in 1971 and the Nobel prize in 1983.  Advances in Maize genomics that have resulted from the Plant Genome Research Program continue to echo the relevance of McClintock’s controversial but transformative research.

Fundamental research in one discipline can often have a profound influence on another. Three scientists with vastly different backgrounds and experiences all share the Nobel Prize for Chemistry. The serendipitous discovery of green fluorescent protein (GFP) by a marine biologist interested in bioluminescence in jelly fish, resulted in an amazingly useful biological tag that allows scientists to track cellular processes. Osamu Shimomura isolated GFP from the bioluminescent jellyfish Aequorea victoria in 1962. Shimomura’s fundamental research was aimed at explaining how marine organisms produce light. In 1988 Cell biologist Martin Chalfie put GFP to use as a cellular marker in studies of nerve cell development. Chalfie introduced the gene for GFP into the DNA of C. elegans and demonstrated that it could be used to monitor gene expression and protein localization in living organisms. Chemist Roger Tsien later developed GFP as a fluorescent probe and produced additional colors. Although GFP is now considered an incredibly important tool, it all started with the search for fundamental knowledge.