The Office of Cancer Clinical Proteomics Research (OCCPR) facilitates the building of an integrated foundation of proteomic technologies, open-data policy, reagents and reference materials, and analysis systems to systematically advance our understanding of cancer biology. The Office manages extramural science programs, including the recently launched Clinical Proteomic Tumor Analysis Consortium (CPTAC), and builds partnership with public-private sectors to further the application of protein science. CPTAC represents a network of Proteome Characterization Centers, which coordinate research approaches and data sharing efforts in order to comprehensively interrogate the protein component of genomically characterized cancer biospecimens, linking cancer genome to cancer phenotype via the understanding of cancer proteome. While genes are the "recipes" of the cell containing all of the instructions for making molecules called proteins and helping with their assembly, proteins and their modifications by other cellular components, the products of these recipes by tightly controlled mechanisms of transcription and translation, serve as the "engines" to carry out cellular functions and drive both normal and disease physiology.
The Antibody Portal serves as a public resource of monoclonal antibodies made available by the NCI for the scientific community to support protein/peptide measurement and analysis efforts.
The Clinical Proteomic Tumor Analysis Consortium (CPTAC) Data Portal provides a platform for researchers to search, download, and analyze data sets generated by CPTAC.