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Center For Cancer Research National Cancer Institute
NCI Resources and Services

Pharmacology


Name

Biopharmaceutical Development Program (SAIC-Frederick)

Expertise

The Biopharmaceutical Development Program (BDP) provides resources for development of monoclonal antibodies, recombinant proteins, therapeutic peptides and DNA vaccines, virus therapeutics and vaccines, gene therapy products, and other biological agents. The BDP provides support from feasibility through development and Phase I/II cGMP manufacturing plus regulatory documentation.

Location

Building 548, NCI-Frederick

Fee Structure



Name

Clinical Pharmacology Program (Office of the Clinical Director, CCR)

Expertise

The Clinical Pharmacology Program (CPP) is dedicated to assessing the pharmacokinetics/pharmacodynamics of clinical trials conducted within the NCI intramural program. The program provides bioanalytical support (LC-MS), pharmacokinetic analysis, and modeling of investigational agents or combination therapies. The CPP can  also assist with determining protein binding, drug-drug interactions, concentration-effect analysis, drug metabolism and routes of elimination for new anticancer agents.

Location

Building 10, Room 5A01, Bethesda

Fee Structure



Name

Pharmacogenetics Core (Office of the Clinical Director, CCR)

Expertise

The Pharmacogenetics Core is responsible for correlating outcome observations (side effects, efficacy or pharmacokinetics results) with genetic variance (mutations or somatic) to identify key genetic determinants and biomarkers that predict response to specific treatments.

Location

Building 10, Room 5A01, Bethesda

Fee Structure



Name

Preclinical Pharmacokinetics Core (Office of the Clinical Director, CCR)

Expertise

The Preclinical Pharmacokinetics Core is open to collaboration for new anticancer agents that are being introduced into preclinical models.  The Core can develop analytical methods to quantitate and characterize preclinical drug metabolism and pharmacokinetics in preclinical models.

Location

Building 10, Room 5A01, Bethesda

Fee Structure



Name

Molecular Targets Core (Genetics Branch, CCR)

Expertise

Assay development and validation; clinical investigation and correlative biomarker studies; mechanistic investigations of investigational new drugs (INDs).

Location

Building 37, Room 6134, Bethesda

Fee Structure



Name

Molecular Targets Laboratory, CCR

Expertise

The Molecular Targets Laboratory (MTL) translates basic science advances into drug leads, bioprobes, and reagents for molecular target evaluation. Compounds of interest include not only classical "drug-like" organic small molecules, but also peptides, proteins, and other bioactive chemical classes.

Location

Building 1052, Room 121, NCI-Frederick

Fee Structure



Name

Molecular Targets Program (Developmental Therapeutics Program, NCI)

Expertise

NCI intramural and extramural researchers can obtain samples from the NCI's panel of 60 human tumor cell lines and measure a variety of targets in these cell lines. Targets include gene mutations, mRNA levels, protein levels and enzyme activities.

Location

Suite 8014, Executive Plaza North (EPN), 6130 Executive Blvd, Rockville

Fee Structure