Decision making for cancer clinical trial participation: a systematic review.

Posted: Jan 26, 2011
Oncol Nurs Forum. 37. 6. E387-99.
KEYWORDS: Knowledge/Attitudes/Beliefs, Logistics/Transportation, Level of Clinical Trials Knowledge or Awareness, Provider-Patient Relationship, Attitudes, Study Burden, Provider Influence


The three main factors that influence the decision-making process for participation in cancer clinical trials are patient, provider, and treatment factors.

Why this item may be useful

More research on the decision-making process for participation in cancer clinical trials is needed. A better understanding of the decision-making process may help improve patient-provider communication and create interventions to facilitate decision-making, leading to increased clinical trial participation.


  • The authors reviewed relevant studies published on PubMed since 2004.
  • Factors that influence clinical trial participation decision making among patients with cancer were identified.
  • Patient factors include clinical trial information, decision-making style preferences, decisional regret, disease characteristics, optimism, quality of life, relative health status, satisfaction with decision making, sociodemographic profile, spirituality, trust in God or medicine, and understanding of purpose.
  • Provider factors were clinical trial information, coercive pressure, communication, and recommendation for participation.
  • Treatment factors were alternative treatment options, benefits and risks, clinical trial information, phase of cancer clinical trial, and time and travel considerations.
Linda Parreco's Image

Read more from Barbara Biedrzycki:

See her article in the Oncology Nursing Forum, 'Factors and outcomes of decision making for cancer clinical trial participation', and her January, 2011 Guest Expert Blog post