Peter H. Bennett, MBChB, FRCP, FFPHM


PECRB
PHOENIX EPIDEMIOLOGY & CLINICAL RESEARCH BRANCH
NIDDK, National Institutes of Health
Building PECRB , Room 706
1550 E Indian School Rd.
Phoenix, AZ 85014
Tel: 602-200-5200
Fax: 602-200-5225
Email: pbennett@mail.nih.gov

Peter H. Bennett, MBChB, FRCP, FFPHM

Education / Previous Training and Experience:
B.Sc., Victoria University of Manchester, United Kingdom, 1958
M.B.,ChB., Manchester, 1961


Research Statement:

Dr. Bennett is Scientist Emeritus and former Chief of the Phoenix Epidemiology and Clinical Research Branch. The Branch is located in Phoenix, Arizona, because of its emphasis on research in American Indian populations. The branch develops and applies epidemiological and clinical methodologies in the investigation of diabetes and its complications, obesity and kidney diseases, which are particularly prevalent among southwestern American Indians.

Major areas under study are diabetes mellitus and obesity.  Field studies, clinical trials and clinical research are conducted in Arizona and collaborative investigations on other selected populations are underway. Inpatient and outpatient clinical studies of diabetes and obesity are carried out in the Phoenix Indian Medical Center.



Selected Publications:

Looker HC, Fagot-Campagna A, Gunter EW, Pfeiffer CM, Sievers ML, Bennett PH, Nelson RG, Hanson RL, Knowler WC: Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res Rev 23: 193-201, 2006

Pavkov ME, Bennett PH, Knowler WC, Krakoff J, Sievers ML, Nelson RG: Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA 296:421-426, 2006

Pavkov ME, Knowler WC, Bennett PH, Looker HC, Krakoff J, Nelson RG: Increasing incidence of proteinuria and declining incidence of end-stage renal disease in diabetic Pima Indians. Kidney Int 70:1840-1846, 2006

Schulz LO, Bennett PH, Ravussin E, Kidd JR, Kidd KK, Esparza J, Valencia ME: Effects of traditional and Western environments on prevalence of type 2 diabetes in Pima indians in Mexico and the U.S. Diabetes Care 29:1866-1871, 2006

Bennett PH: An internist's perspective: type 2 diabetes in childhood and adolescence: what does the future hold? Pediatr.Diabetes 8:352-353, 2007

Pavkov ME, Hanson RL, Knowler WC, Bennett PH, Krakoff J, Nelson RG: Changing patterns of type 2 diabetes incidence among Pima Indians Diabetes Care 30:1758-1763, 2007

Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, Arslanian S, Wong G, Bennett P, Shaw J, Caprio S: The metabolic syndrome in children and adolescents - an IDF consensus report Pediatr.Diabetes 8:299-306, 2007

Zimmet P, Alberti G, Kaufman F, Tajima N, Silink M, Arslanian S, Wong G, Bennett P, Shaw J, Caprio S: The metabolic syndrome in children and adolescents Lancet 369:2059-2061, 2007

Kim NH, Pavkov ME, Looker HC, Nelson RG, Bennett PH, Hanson RL, Curtis JM, Sievers ML, Knowler WC: Plasma glucose regulation and mortality in Pima Indians Diabetes Care 31:488-492, 2008

Li G, Zhang P, Wang J, Gregg EW, Yang W, Gong Q, Li H, Li H, Jiang Y, An Y, Shuai Y, Zhang B, Zhang J, Thompson TJ, Gerzoff RB, Roglic G, Hu Y, Bennett PH: The long-term effect of lifestyle interventions to prevent diabbetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
. Lancet 371:1783-1789, 2008

Pavkov ME, Knowler WC, Hanson RL, Bennett PH, Nelson RG: Predictive power of sequential measures of albuminuria for progression to ESRD or death in Pima Indians with type 2 diabetes Am J Kidney Dis. 51:759-766, 2008

Ratner RE, Christophi CA, Metzger BE, Dabelea D, Bennett PH, Pi-Sunyer X, Fowler S, Kahn SE: Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions. J Clin Endocrinol Metab 93:4774-4779, 2008

Hoehner CM, Williams DE, Sievers ML, Knowler WC, Bennett PH, Nelson RG Trends in heart disease death rates in diabetic and nondiabetic Pima Indians. J Diabetes Complications (20): 8-13, 2006. [Full Text/Abstract]

Saremi A, Nelson RG, Tulloch-Reid M, Hanson RL, Sievers ML, Taylor GW, Shlossman M, Bennett PH, Genco R, Knowler WC Periodontal disease and mortality in type 2 diabetes. Diabetes Care (28): 27-32, 2005. [Full Text/Abstract]

Pavkov ME, Bennett PH, Sievers ML, Krakoff J, Williams DE, Knowler WC, Nelson RG Predominant effect of kidney disease on mortality in Pima Indians with or without type 2 diabetes. Kidney Int (68): 1267-74, 2005. [Full Text/Abstract]

Dirks JH, de Zeeuw D, Agarwal SK, Atkins RC, Correa-Rotter R, D''Amico G, Bennett PH, El Nahas M, Valdes RH, Kaseje D, Katz IJ, Naicker S, Rodriguez-Iturbe B, Schieppati A, Shaheen F, Sitthi-Amorn C, Solez K, Viberti G, Remuzzi G, Weening JJKidney Int Suppl : S1-6, 2005. [Full Text/Abstract]

Roglic G, Unwin N, Bennett PH, Mathers C, Tuomilehto J, Nag S, Connolly V, King H The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care (28): 2130-5, 2005. [Full Text/Abstract]

Pavkov ME, Sievers ML, Knowler WC, Bennett PH, Nelson RG An explanation for the increase in heart disease mortality rates in diabetic Pima Indians: effect of renal replacement therapy. Diabetes Care (27): 1132-6, 2004. [Full Text/Abstract]

Singh PK, Looker HC, Hanson RL, Krakoff J, Bennett PH, Knowler WC Depression, diabetes, and glycemic control in Pima Indians. Diabetes Care (27): 618-9, 2004. [Full Text/Abstract]

Steyn NP, Mann J, Bennett PH, Temple N, Zimmet P, Tuomilehto J, Lindstrom J, Louheranta A Diet, nutrition and the prevention of type 2 diabetes. Public Health Nutr (7): 147-65, 2004. [Full Text/Abstract]

Lindsay RS, Funahashi T, Krakoff J, Matsuzawa Y, Tanaka S, Kobes S, Bennett PH, Tataranni PA, Knowler WC, Hanson RL Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes (52): 2419-25, 2003. [Full Text/Abstract]

Looker HC, Krakoff J, Knowler WC, Bennett PH, Klein R, Hanson RL Longitudinal studies of incidence and progression of diabetic retinopathy assessed by retinal photography in pima indians. Diabetes Care (26): 320-6, 2003. [Full Text/Abstract]

Kriska AM, Saremi A, Hanson RL, Bennett PH, Kobes S, Williams DE, Knowler WC Physical activity, obesity, and the incidence of type 2 diabetes in a high-risk population. Am J Epidemiol (158): 669-75, 2003. [Full Text/Abstract]

Lindsay RS, Hanson RL, Wiedrich C, Knowler WC, Bennett PH, Baier LJ The insulin gene variable number tandem repeat class I/III polymorphism is in linkage disequilibrium with birth weight but not Type 2 diabetes in the Pima population. Diabetes (52): 187-93, 2003. [Full Text/Abstract]

Enzer I, Dunn G, Jacobsson L, Bennett PH, Knowler WC, Silman A An epidemiologic study of trends in prevalence of rheumatoid factor seropositivity in Pima Indians: evidence of a decline due to both secular and birth-cohort influences. Arthritis Rheum (46): 1729-34, 2002. [Full Text/Abstract]

Hanson RL, Imperatore G, Bennett PH, Knowler WC Components of the "metabolic syndrome" and incidence of type 2 diabetes. Diabetes (51): 3120-7, 2002. [Full Text/Abstract]

Li G, Hu Y, Yang W, Jiang Y, Wang J, Xiao J, Hu Z, Pan X, Howard BV, Bennett PH. Effects of insulin resistance and insulin secretion on the efficacy of interventions to retard development of type 2 diabetes mellitus: the DaQing IGT and diabetes study. Diabetes Res Clin Pract (58): 193-200, 2002. [Full Text/Abstract]

Howard BV, Rodriguez BL, Bennett PH, Harris MI, Hamman R, Kuller LH, Pearson TA, Wylie-Rosett J Prevention Conference VI: Diabetes and Cardiovascular disease: Writing Group I: epidemiology. Circulation (105): e132-7, 2002. [Full Text/Abstract]

Kriska AM, Pereira MA, Hanson RL, de Courten MP, Zimmet PZ, Alberti KG, Chitson P, Bennett PH, Narayan KM, Knowler WC Association of physical activity and serum insulin concentrations in two populations at high risk for type 2 diabetes but differing by BMI. Diabetes Care (24): 1175-80, 2001. [Full Text/Abstract]

Hanson RL, Imperatore G, Narayan KM, Roumain J, Fagot-Campagna A, Pettitt DJ, Bennett PH, Knowler WC Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians. Diabetes Metab Res Rev (17): 296-303, 2001. [Full Text/Abstract]

Lindsay RS, Krakoff J, Hanson RL, Bennett PH, Knowler WC Gamma globulin levels predict type 2 diabetes in the Pima Indian population. Diabetes (50): 1598-603, 2001. [Full Text/Abstract]

Lindsay RS, Kobes S, Knowler WC, Bennett PH, Hanson RL Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians. Diabetes (50): 2850-7, 2001. [Full Text/Abstract]

Bennett PH, Lee ET, Lu M, Keen H, Fuller JH Increased urinary albumin excretion and its associations in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia (44 Suppl 2): S37-45, 2001. [Full Text/Abstract]

Jacobsson LT, Turesson C, Hanson RL, Pillemer S, Sievers ML, Pettitt DJ, Bennett PH, Knowler WC Joint swelling as a predictor of death from cardiovascular disease in a population study of Pima Indians. Arthritis Rheum (44): 1170-6, 2001. [Full Text/Abstract]

Colhoun HM, Lee ET, Bennett PH, Lu M, Keen H, Wang SL, Stevens LK, Fuller JH Risk factors for renal failure: the WHO Mulinational Study of Vascular Disease in Diabetes. Diabetologia (44 Suppl 2): S46-53, 2001. [Full Text/Abstract]

Keen H, Lee ET, Russell D, Miki E, Bennett PH, Lu M The appearance of retinopathy and progression to proliferative retinopathy: the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia (44 Suppl 2): S22-30, 2001. [Full Text/Abstract]

Williams DE, Knowler WC, Smith CJ, Hanson RL, Roumain J, Saremi A, Kriska AM, Bennett PH, Nelson RG The effect of Indian or Anglo dietary preference on the incidence of diabetes in Pima Indians. Diabetes Care (24): 811-6, 2001. [Full Text/Abstract]

Miki E, Lu M, Lee ET, Keen H, Bennett PH, Russell D The incidence of visual impairment and its determinants in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia (44 Suppl 2): S31-6, 2001. [Full Text/Abstract]

Lindsay RS, Bennett PH Type 2 diabetes, the thrifty phenotype - an overview. Br Med Bull (60): 21-32, 2001. [Full Text/Abstract]

Lee ET, Lu M, Bennett PH, Keen H Vascular disease in younger-onset diabetes: comparison of European, Asian and American Indian cohorts of the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia (44 Suppl 2): S78-81, 2001. [Full Text/Abstract]

Chi ZS, Lee ET, Lu M, Keen H, Bennett PH Vascular disease prevalence in diabetic patients in China: standardised comparison with the 14 centres in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia (44 Suppl 2): S82-6, 2001. [Full Text/Abstract]

Imperatore G, Knowler WC, Pettitt DJ, Kobes S, Fuller JH, Bennett PH, Hanson RL A locus influencing total serum cholesterol on chromosome 19p: results from an autosomal genomic scan of serum lipid concentrations in Pima Indians. Arterioscler Thromb Vasc Biol (20): 2651-6, 2000. [Full Text/Abstract]

Brun E, Nelson RG, Bennett PH, Imperatore G, Zoppini G, Verlato G, Muggeo MDiabetes Care (23): 1119-23, 2000. [Full Text/Abstract]

Lemley KV, Abdullah I, Myers BD, Meyer TW, Blouch K, Smith WE, Bennett PH, Nelson RG Evolution of incipient nephropathy in type 2 diabetes mellitus. Kidney Int (58): 1228-37, 2000. [Full Text/Abstract]

Lemley KV, Blouch K, Abdullah I, Boothroyd DB, Bennett PH, Myers BD, Nelson RG Glomerular permselectivity at the onset of nephropathy in type 2 diabetes mellitus. J Am Soc Nephrol (11): 2095-105, 2000. [Full Text/Abstract]

Dabelea D, Hanson RL, Lindsay RS, Pettitt DJ, Imperatore G, Gabir MM, Roumain J, Bennett PH, Knowler WC Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes (49): 2208-11, 2000. [Full Text/Abstract]

Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, Knowler WC Plasma glucose and prediction of microvascular disease and mortality: evaluation of 1997 American Diabetes Association and 1999 World Health Organization criteria for diagnosis of diabetes. Diabetes Care (23): 1113-8, 2000. [Full Text/Abstract]

Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, Knowler WC Plasma glucose and prediction of microvascular disease and mortality: evaluation of 1997 American Diabetes Association and 1999 World Health Organization criteria for diagnosis of diabetes. Diabetes Care (23): 1113-8, 2000. [Full Text/Abstract]

Lindsay RS, Hanson RL, Bennett PH, Knowler WC Secular trends in birth weight, BMI, and diabetes in the offspring of diabetic mothers. Diabetes Care (23): 1249-54, 2000. [Full Text/Abstract]

Imperatore G, Knowler WC, Pettitt DJ, Kobes S, Bennett PH, Hanson RL Segregation analysis of diabetic nephropathy in Pima Indians. Diabetes (49): 1049-56, 2000. [Full Text/Abstract]

Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, Knowler WC The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. Diabetes Care (23): 1108-12, 2000. [Full Text/Abstract]

Gabir MM, Hanson RL, Dabelea D, Imperatore G, Roumain J, Bennett PH, Knowler WC The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. Diabetes Care (23): 1108-12, 2000. [Full Text/Abstract]

Lindsay RS, Dabelea D, Roumain J, Hanson RL, Bennett PH, Knowler WC Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes. Diabetes (49): 445-9, 2000. [Full Text/Abstract]

Dabelea D, Palmer JP, Bennett PH, Pettitt DJ, Knowler WC Absence of glutamic acid decarboxylase antibodies in Pima Indian children with diabetes mellitus. Diabetologia (42): 1265-6, 1999. [Full Text/Abstract]

Dabelea D, Pettitt DJ, Hanson RL, Imperatore G, Bennett PH, Knowler WC Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults. Diabetes Care (22): 944-50, 1999. [Full Text/Abstract]

Nelson RG, Tan M, Beck GJ, Bennett PH, Knowler WC, Mitch WE, Blouch K, Myers BD Changing glomerular filtration with progression from impaired glucose tolerance to Type II diabetes mellitus. Diabetologia (42): 90-3, 1999. [Full Text/Abstract]

Sievers ML, Bennett PH, Nelson RG Effect of glycemia on mortality in Pima Indians with type 2 diabetes. Diabetes (48): 896-902, 1999. [Full Text/Abstract]

Sievers ML, Bennett PH, Roumain J, Nelson RG Effect of hypertension on mortality in Pima Indians. Circulation (100): 33-40, 1999. [Full Text/Abstract]

Bennett PH Impact of the new WHO classification and diagnostic criteria. Diabetes Obes Metab (1 Suppl 2): S1-6, 1999. [Full Text/Abstract]

Fox C, Esparza J, Nicolson M, Bennett PH, Schulz LO, Valencia ME, Ravussin E Plasma leptin concentrations in Pima Indians living in drastically different environments. Diabetes Care (22): 413-7, 1999. [Full Text/Abstract]

Meyer TW, Bennett PH, Nelson RG Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria. Diabetologia (42): 1341-4, 1999. [Full Text/Abstract]




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