William C. Knowler, M.D., Ph.D., M.P.H.


PECRB
DIABETES EPDMLGY & CLINICAL RESEARCH SECTION
NIDDK, National Institutes of Health
Building PECRB , Room 605
1550 E Indian School Rd.
Phoenix, AZ 85014
Tel: 602-200-5206
Fax: 602-200-5225
Email: wknowler@phx.niddk.nih.gov

William C. Knowler, M.D., Ph.D., M.P.H.

Education / Previous Training and Experience:
B.A., University of Iowa, 1968
M.D., Harvard, 1973
M.P.H., Harvard, 1973
Dr.P.H., Harvard, 1980


Selected Publications:

Looker HC Krakoff J Funahashi T Matsuzawa Y Tanaka S Nelson RG Knowler WC Lindsay RS Hanson RL Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes. J Clin Endocrinol Metab (89): 4010-7, 2004. [Full Text/Abstract]

Saremi A Hanson RL Tulloch-Reid M Williams DE Knowler WC Alcohol consumption predicts hypertension but not diabetes. J Stud Alcohol (65): 184-90, 2004. [Full Text/Abstract]

Pavkov ME Sievers ML Knowler WC Bennett PH Nelson RG An explanation for the increase in heart disease mortality rates in diabetic Pima Indians: effect of renal replacement therapy. Diabetes Care (27): 1132-6, 2004. [Full Text/Abstract]

Tulloch-Reid MK Hanson RL Saremi A Looker HC Williams DE Krakoff J Knowler WC Hematocrit and the incidence of type 2 diabetes in the pima indians. Diabetes Care (27): 2245-6, 2004. [Full Text/Abstract]

Collins-Schramm HE Chima B Morii T Wah K Figueroa Y Criswell LA Hanson RL Knowler WC Silva G Belmont JW Seldin MF Mexican American ancestry-informative markers: examination of population structure and marker characteristics in European Americans, Mexican Americans, Amerindians and Asians. Hum Genet (114): 263-71, 2004. [Full Text/Abstract]

Tulloch-Reid MK Williams DE Looker HC Hanson RL Knowler WC Do measures of body fat distribution provide information on the risk of type 2 diabetes in addition to measures of general obesity? Comparison of anthropometric predictors of type 2 diabetes in Pima Indians. Diabetes Care (26): 2556-61, 2003. [Full Text/Abstract]

Genuth S Alberti KG Bennett P Buse J Defronzo R Kahn R Kitzmiller J Knowler WC Lebovitz H Lernmark A Nathan D Palmer J Rizza R Saudek C Shaw J Steffes M Stern M Tuomilehto J Zimmet P Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care (26): 3160-7, 2003. [Full Text/Abstract]

Hsueh WC St Jean PL Mitchell BD Pollin TI Knowler WC Ehm MG Bell CJ Sakul H Wagner MJ Burns DK Shuldiner AR Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24. Diabetes (52): 550-7, 2003. [Full Text/Abstract]

Lindsay RS Funahashi T Krakoff J Matsuzawa Y Tanaka S Kobes S Bennett PH Tataranni PA Knowler WC Hanson RL Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes (52): 2419-25, 2003. [Full Text/Abstract]

Looker HC Fagot-Campagna A Gunter EW Pfeiffer CM Narayan KM Knowler WC Hanson RL Homocysteine as a risk factor for nephropathy and retinopathy in Type 2 diabetes. Diabetologia (46): 766-72, 2003. [Full Text/Abstract]

Krakoff J Lindsay RS Looker HC Nelson RG Hanson RL Knowler WC Incidence of retinopathy and nephropathy in youth-onset compared with adult-onset type 2 diabetes. Diabetes Care (26): 76-81, 2003. [Full Text/Abstract]

Krakoff J Funahashi T Stehouwer CD Schalkwijk CG Tanaka S Matsuzawa Y Kobes S Tataranni PA Hanson RL Knowler WC Lindsay RS Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian. Diabetes Care (26): 1745-51, 2003. [Full Text/Abstract]

Looker HC Krakoff J Knowler WC Bennett PH Klein R Hanson RL Longitudinal studies of incidence and progression of diabetic retinopathy assessed by retinal photography in pima indians. Diabetes Care (26): 320-6, 2003. [Full Text/Abstract]

Ryan DH Espeland MA Foster GD Haffner SM Hubbard VS Johnson KC Kahn SE Knowler WC Yanovski SZ Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control Clin Trials (24): 610-28, 2003. [Full Text/Abstract]

Jacobsson LT Jacobsson ME Askling J Knowler WC Perinatal characteristics and risk of rheumatoid arthritis. BMJ (326): 1068-9, 2003. [Full Text/Abstract]

Kriska AM Saremi A Hanson RL Bennett PH Kobes S Williams DE Knowler WC Physical activity, obesity, and the incidence of type 2 diabetes in a high-risk population. Am J Epidemiol (158): 669-75, 2003. [Full Text/Abstract]

Hanson RL Knowler WC Quantitative trait linkage studies of diabetes-related traits. Curr Diab Rep (3): 176-83, 2003. [Full Text/Abstract]

Lindsay RS Hanson RL Wiedrich C Knowler WC Bennett PH Baier LJ The insulin gene variable number tandem repeat class I/III polymorphism is in linkage disequilibrium with birth weight but not Type 2 diabetes in the Pima population. Diabetes (52): 187-93, 2003. [Full Text/Abstract]

Vozarova B Fernandez-Real JM Knowler WC Gallart L Hanson RL Gruber JD Ricart W Vendrell J Richart C Tataranni PA Wolford JK The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet (112): 409-13, 2003. [Full Text/Abstract]

Lindsay RS Funahashi T Hanson RL Matsuzawa Y Tanaka S Tataranni PA Knowler WC Krakoff J Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet (360): 57-8, 2002. [Full Text/Abstract]

Enzer I Dunn G Jacobsson L Bennett PH Knowler WC Silman A An epidemiologic study of trends in prevalence of rheumatoid factor seropositivity in Pima Indians: evidence of a decline due to both secular and birth-cohort influences. Arthritis Rheum (46): 1729-34, 2002. [Full Text/Abstract]

Hanson RL Imperatore G Bennett PH Knowler WC Components of the "metabolic syndrome" and incidence of type 2 diabetes. Diabetes (51): 3120-7, 2002. [Full Text/Abstract]

Lindsay RS Prochazka M Baier LJ Knowler WC Bogardus C Hanson RL Currently identified genes affecting insulin resistance are not associated with birth weight in the Pima population. Diabet Med (19): 882-4, 2002. [Full Text/Abstract]

Lindsay RS Cook V Hanson RL Salbe AD Tataranni A Knowler WC Early excess weight gain of children in the Pima Indian population. Pediatrics (109): E33, 2002. [Full Text/Abstract]

Collins-Schramm HE Phillips CM Operario DJ Lee JS Weber JL Hanson RL Knowler WC Cooper R Li H Seldin MF Ethnic-difference markers for use in mapping by admixture linkage disequilibrium. Am J Hum Genet (70): 737-50, 2002. [Full Text/Abstract]

Lindsay RS Kobes S Knowler WC Hanson RL Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of birth weight. Hum Genet (110): 503-9, 2002. [Full Text/Abstract]

Knowler WC Barrett-Connor E Fowler SE Hamman RF Lachin JM Walker EA Nathan DM Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (346): 393-403, 2002. [Full Text/Abstract]

Rubin RR Fujimoto WY Marrero DG Brenneman T Charleston JB Edelstein SL Fisher EB Jordan R Knowler WC Lichterman LC Prince M Rowe PM The Diabetes Prevention Program: recruitment methods and results. Control Clin Trials (23): 157-71, 2002. [Full Text/Abstract]

Neamat-Allah M Feeney SA Savage DA Maxwell AP Hanson RL Knowler WC El Nahas AM Plater ME Shaw J Boulton AJ Duff GW Cox A Analysis of the association between diabetic nephropathy and polymorphisms in the aldose reductase gene in Type 1 and Type 2 diabetes mellitus. Diabet Med (18): 906-14, 2001. [Full Text/Abstract]

Hanson RL Kobes S Lindsay RS Knowler WC Assessment of parent-of-origin effects in linkage analysis of quantitative traits. Am J Hum Genet (68): 951-62, 2001. [Full Text/Abstract]

Kriska AM Pereira MA Hanson RL de Courten MP Zimmet PZ Alberti KG Chitson P Bennett PH Narayan KM Knowler WC Association of physical activity and serum insulin concentrations in two populations at high risk for type 2 diabetes but differing by BMI. Diabetes Care (24): 1175-80, 2001. [Full Text/Abstract]

Lindsay RS Hanson RL Roumain J Ravussin E Knowler WC Tataranni PA Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy x-ray absorptiometry and to cardiovascular risk factors. J Clin Endocrinol Metab (86): 4061-7, 2001. [Full Text/Abstract]

Looker HC Knowler WC Hanson RL Changes in BMI and weight before and after the development of type 2 diabetes. Diabetes Care (24): 1917-22, 2001. [Full Text/Abstract]

Krakoff J Hanson RL Kobes S Knowler WC Comparison of the effect of plasma glucose concentrations on microvascular disease between Pima Indian youths and adults. Diabetes Care (24): 1023-8, 2001. [Full Text/Abstract]

Hanson RL Imperatore G Narayan KM Roumain J Fagot-Campagna A Pettitt DJ Bennett PH Knowler WC Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians. Diabetes Metab Res Rev (17): 296-303, 2001. [Full Text/Abstract]

Lindsay RS Krakoff J Hanson RL Bennett PH Knowler WC Gamma globulin levels predict type 2 diabetes in the Pima Indian population. Diabetes (50): 1598-603, 2001. [Full Text/Abstract]

Imperatore G Knowler WC Nelson RG Hanson RL Genetics of diabetic nephropathy in the Pima Indians. Curr Diab Rep (1): 275-81, 2001. [Full Text/Abstract]

Lindsay RS Kobes S Knowler WC Bennett PH Hanson RL Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians. Diabetes (50): 2850-7, 2001. [Full Text/Abstract]

Jacobsson LT Turesson C Hanson RL Pillemer S Sievers ML Pettitt DJ Bennett PH Knowler WC Joint swelling as a predictor of death from cardiovascular disease in a population study of Pima Indians. Arthritis Rheum (44): 1170-6, 2001. [Full Text/Abstract]

Gautier JF Wilson C Weyer C Mott D Knowler WC Cavaghan M Polonsky KS Bogardus C Pratley RE Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes. Diabetes (50): 1828-33, 2001. [Full Text/Abstract]

Williams DE Knowler WC Smith CJ Hanson RL Roumain J Saremi A Kriska AM Bennett PH Nelson RG The effect of Indian or Anglo dietary preference on the incidence of diabetes in Pima Indians. Diabetes Care (24): 811-6, 2001. [Full Text/Abstract]

Lindsay RS Hanson RL Knowler WC Tracking of body mass index from childhood to adolescence: a 6-y follow-up study in China. Am J Clin Nutr (74): 149-50, 2001. [Full Text/Abstract]

Saremi A Hanson RL Williams DE Roumain J Robin RW Long JC Goldman D Knowler WC Validity of the CAGE questionnaire in an American Indian population. J Stud Alcohol (62): 294-300, 2001. [Full Text/Abstract]

Baier LJ Permana PA Yang X Pratley RE Hanson RL Shen GQ Mott D Knowler WC Cox NJ Horikawa Y Oda N Bell GI Bogardus C A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J Clin Invest (106): R69-73, 2000. [Full Text/Abstract]

Imperatore G Knowler WC Pettitt DJ Kobes S Fuller JH Bennett PH Hanson RL A locus influencing total serum cholesterol on chromosome 19p: results from an autosomal genomic scan of serum lipid concentrations in Pima Indians. Arterioscler Thromb Vasc Biol (20): 2651-6, 2000. [Full Text/Abstract]

Walder K Hanson RL Kobes S Knowler WC Ravussin E An autosomal genomic scan for loci linked to plasma leptin concentration in Pima Indians. Int J Obes Relat Metab Disord (24): 559-65, 2000. [Full Text/Abstract]

Jenkinson CP Hanson R Cray K Wiedrich C Knowler WC Bogardus C Baier L Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians. Int J Obes Relat Metab Disord (24): 1233-8, 2000. [Full Text/Abstract]

Dabelea D Hanson RL Lindsay RS Pettitt DJ Imperatore G Gabir MM Roumain J Bennett PH Knowler WC Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes (49): 2208-11, 2000. [Full Text/Abstract]

Gabir MM Hanson RL Dabelea D Imperatore G Roumain J Bennett PH Knowler WC Plasma glucose and prediction of microvascular disease and mortality: evaluation of 1997 American Diabetes Association and 1999 World Health Organization criteria for diagnosis of diabetes. Diabetes Care (23): 1113-8, 2000. [Full Text/Abstract]

Lindsay RS Hanson RL Bennett PH Knowler WC Secular trends in birth weight, BMI, and diabetes in the offspring of diabetic mothers. Diabetes Care (23): 1249-54, 2000. [Full Text/Abstract]

Imperatore G Knowler WC Pettitt DJ Kobes S Bennett PH Hanson RL Segregation analysis of diabetic nephropathy in Pima Indians. Diabetes (49): 1049-56, 2000. [Full Text/Abstract]

Gabir MM Hanson RL Dabelea D Imperatore G Roumain J Bennett PH Knowler WC The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. Diabetes Care (23): 1108-12, 2000. [Full Text/Abstract]

Lindsay RS Dabelea D Roumain J Hanson RL Bennett PH Knowler WC Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes. Diabetes (49): 445-9, 2000. [Full Text/Abstract]



Dr. Knowler has worked with American Indians in the Southwest since 1975. His work focuses on the risk factors for type 2 diabetes mellitus and its complications (especially diabetic nephropathy and retinopathy), obesity and its relationship to diabetes, diagnostic criteria for diabetes, and on methods in genetic epidemiology. Current activities concentrate on the genetics and prevention of diabetes and its complications. These include pedigree and genetics studies, the Diabetes Prevention Program, a multi-center clinical trial in prevention of type 2 diabetes, and Look AHEAD, a multi-center clinical trial of weight loss in prevention of cardiovascular complications of type 2 diabetes.


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Page last updated: June 30, 2009

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