Biological Atomic Force Microscopy (AFM)

Four Multimodal AFM instrument platforms at BIMI

Contents

AFM Capabilities

Biomedical Instrumentation and Multiscale Imaging (BIMI) AFM Specialists

Recent Projects

• Clathrin and Clathrin-Coated Vesicles
• Biomembrane Structure & GPCR Dynamics
• Cytochrome c Localization in Anionic Lipid Bilayers
• Nanoindentation of Biological Tissue

AFM Capabilities

Combining high-resolution AFM under physiological conditions with sensitive force measurements
and mathematical modeling to gain greater understanding of complex biological systems.

Imaging
Atomic resolution: ~ 0.1 nm under physiological conditions, dynamic changes, temperature studies, etc.

Force Measurement
Biomolecular: ~ 1 pN to tissue level; ~1 m N force and force modulation

Commercial equipment

• Multimode PicoForce AFM
• TIRF AFM (Bioscope Z)
• Raman (LabRam) AFM (XE-120)
• Single Molecule Force Spectroscopy (SMFS) AFM (ForceRobot)

Technologies

• Multi-modality (Raman, TIRF, NSOM, etc.) 
• Environmental Control
• Carbon Nanotube Tips
• Surface Modifications

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BIMI AFM Specialists

For more information, contact the BIMI staff:

Paul D. Smith, Ph.D. - Chief

Albert J. Jin, Ph.D. - Staff Scientist

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