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 National Cancer Institute at the National Institutes of Health.  Website is www.cancer.gov
Technology Transfer Center of the National Cancer Institute

Velcade®

Velcade box

NIH's (NCI) Contribution

  • Conducted preclinical studies for Velcade®
  • Developed a formulation with a longer, stable shelf life

Industrial Partners' Contribution

  • Myogenetics synthesized the active ingredient for Velcade®
  • ProScript conducted preclinical oncology studies in collaboration with institutions including the NCI, NIH
  • Millennium Pharmaceuticals initiated the clinical trials that resulted in FDA approval

Results of Collaboration

  • Product -- Anti-cancer drug Velcade®
  • FDA approved Velcade® as treatment for refractory multiple myeloma, which accounts for 2% of all cancer deaths each year
  • Velcade® is being clinically tested against ovarian, colon, pancreatic, lung, and prostate cancers, as well as leukemia and non-Hodgkin's lymphoma