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Leading small business innovation and commercialization in the fight against cancer
What are SBIR & STTR?

The goal of the NCI is to eliminate the suffering and death due to cancer. The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs are NCI's engine of innovation for developing and commercializing novel technologies and products to prevent, diagnose, and treat cancer.

The SBIR & STTR Programs are one of the largest sources of early-stage technology financing in the United States. We welcome entrepreneurs and small business leaders to this website to explore grant and contract funding opportunities and a new spirit of collaboration with the NCI.

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Michael Weingarten, Director of the NCI SBIR & STTR Programs discusses how the program began and why it is so important to improving cancer treatments and care for patients.

Program Announcements

Acknowledging NCI Funding in News Stories

NIH requires grantees to acknowledge federal funding in stories released for public dissemination, including news releases, peer-reviewed publications, and presentations. We are asking all awardees to begin mentioning their NIH grant or contract number specifically in all external communications of this nature. Click here for additional information.

Call for Applications – NCI Clinical Assay Development Program

The NCI Clinical Assay Development Program (CADP) is requesting project applications from investigators seeking clinical assay validation resources that are designed to assist with the development of assays that may predict therapy response or prognostic behavior of a diagnosed cancer, primarily for use in clinical trials. Approved projects for the NCI CADP will be provided access to the Institute's assay development and validation resources, including project management support. For more information on the CADP or to submit an application, please visit: Please note that this call for applications is not a solicitation for biomarker discovery and is not a grants program.

Upcoming Receipt Date: February 15, 2013

Innovative Partnerships for Commercializing Health Information Technology

The National Cancer Institute (NCI) announced a new Program Announcement, aimed at accelerating the development and commercialization of consumer health information technology products that translate the behavioral and communication science evidence base for the prevention and control of cancer and other chronic diseases. The NCI and the National Library of Medicine (a co-funding partner) are interested in supporting the development and dissemination of evidence-based health information technology (health IT) products that have the potential to prevent or reduce the risk of cancer, facilitate patient-provider communication and/or improve disease outcomes in consumer and clinical settings. Please click here for more information.

Upcoming Receipt Date: April 5, 2013

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Share Your Company's Success Story

The NCI SBIR Development Center is interested in learning more about how SBIR & STTR funding is helping your company to achieve its cancer research goals and business objectives. Please click here to fill out a 'Share Your Story' form, and let us know about any developments with your NCI SBIR- or STTR-funded projects. Learn more about how other successful NCI SBIR & STTR companies are using their funding awards to advance cancer research.

Tips for Applying: Granting You Success

Learn about Funding & Resources Available from the NCI SBIR & STTR Programs

NCI SBIR Development Center Director Michael Weingarten led a webinar in October 2012 for state Biotechnology Industry Organization (BIO) members. The webinar was held in collaboration with the Council of State Bioscience Associations (CSBA), and focused on the SBIR & STTR Programs, upcoming legislative changes that will expand the program, and funding opportunities aimed at progressing cancer research. Please click here to view the presentation from this webinar.

Central Contractor Registry (CCR) Transitioned to New System for Award Management (SAM)

At the end of July 2012, CCR services moved to a new system called SAM. Click here for more information.

Nature Biotechnology Publishes Article on the SBIR & STTR Programs

In an article published in Nature Biotechnology, SBIR & STTR Development Center staff discuss the application process and provide tips for applying for funding through the SBIR & STTR Programs.


Latest Announcements

Small Businesses Highlighted in NCI FY2013 Plan & Budget Proposal

Each year, the NCI prepares a budget proposal describing NCI-supported scientific advancements and how the nation works together to control cancer and its effects. Please click here to view the 2013 plan.

$10M for SBIR Phase IIB Bridge Awards Now Available

NCI intends to commit $10M for up to ten new Phase IIB Bridge awards in FY2013. Click here to learn more.

Apply by: March 6, 2013

SBIR/STTR Reauthorization Updates

For ongoing updates on NIH implementation of key changes from the SBIR/STTR Reauthorization Act of 2011, please continue to check the NIH implementation plan website.

To review a summary of the key changes, please visit

NCI SBIR & STTR Grant Funding Available for:

  • Innovative Health IT for Broad Adoption by Healthcare Systems and Consumers
  • Cancer Diagnostic and Therapeutic Agents Enabled by Nanotechnology

View a complete list of funding opportunities.

Featured 2012 SBIR Investor Forum Presenting Companies

NCI Provocative Questions Initiative

NCI Director Harold Varmus launched a website as part of the Provocative Questions Initiative to identify the most important questions in the cancer research community.